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Protein

Uncharacterized protein C1orf106

Gene

C1orf106

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf106
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25599. C1orf106.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672490.

Polymorphism and mutation databases

BioMutaiC1orf106.
DMDMi317373328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Uncharacterized protein C1orf106PRO_0000251729Add
BLAST

Proteomic databases

EPDiQ3KP66.
MaxQBiQ3KP66.
PaxDbiQ3KP66.
PeptideAtlasiQ3KP66.
PRIDEiQ3KP66.

PTM databases

iPTMnetiQ3KP66.
PhosphoSiteiQ3KP66.

Expressioni

Gene expression databases

BgeeiQ3KP66.
CleanExiHS_C1orf106.
ExpressionAtlasiQ3KP66. baseline and differential.
GenevisibleiQ3KP66. HS.

Organism-specific databases

HPAiHPA027499.
HPA027511.

Interactioni

Protein-protein interaction databases

BioGridi120883. 22 interactions.
IntActiQ3KP66. 1 interaction.
MINTiMINT-3976349.
STRINGi9606.ENSP00000356311.

Structurei

3D structure databases

ProteinModelPortaliQ3KP66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 14730Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi282 – 35776Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
HOGENOMiHOG000233699.
HOVERGENiHBG080963.
InParanoidiQ3KP66.
OMAiWWHERAR.
OrthoDBiEOG72ZCDV.
PhylomeDBiQ3KP66.
TreeFamiTF328984.

Family and domain databases

InterProiIPR021774. DUF3338.
[Graphical view]
PfamiPF11819. DUF3338. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KP66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQMPKLNEI PPGRAGRREA RGEGRWPGQT GPEAARLEWR AQGQAGGARA
60 70 80 90 100
PWDSWGSSRL PTQPGPGWSR CPPSLLCALS FQKSTMESKD EVSDTDSGII
110 120 130 140 150
LQSGPDSPVS PMKELTHAVH KQQRALEARL EACLEELRRL CLREAELTGT
160 170 180 190 200
LPAEYPLKPG EKAPKVRRRI GAAYKLDDWA LHREDPLSSL ERQLALQLQI
210 220 230 240 250
TEAARRLCLE ENLSRQARRQ RKHSMLQEEK KLQELQRCLV ERRRNSEPPP
260 270 280 290 300
AAALPLGREL SASDDSSLSD GLLLEEEESQ VPKPPPESPA PPSRPLPPQT
310 320 330 340 350
LEGLQPTGPE AGSPERAPVQ NSPWKETSLD HPYEKPRKSS EPWSESSSPA
360 370 380 390 400
TTPQDGPSAS SLWLLEPASY HVVPIRGVPG QWQGRTSAPA TPEIQGRRGQ
410 420 430 440 450
SQSLRVDSFR AGPEGRGRSA FPRRRPTHYT VTVPDSCFPA TKPPLPHAAC
460 470 480 490 500
HSCSEDSGSD VSSISHPTSP GSSSPDISFL QPLSPPKTHR HRGAWVPAGS
510 520 530 540 550
RELVAHHPKL LLPPGYFPAG RYVVVAESPL PPGEWELRRA APGPAYEEEG
560 570 580 590 600
TPLRYQRLVP SRSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS
610 620 630 640 650
TRPHSLDRQG AFRVRSLPLG REGFGRALGP RAQVPTVCVL RRSPDGAPVQ
660
VFVPEKGEII SQV
Length:663
Mass (Da):72,914
Last modified:January 11, 2011 - v2
Checksum:i77EB3D76DC55EF8A
GO
Isoform 2 (identifier: Q3KP66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:578
Mass (Da):63,695
Checksum:i92B58F00B878C9B5
GO

Sequence cautioni

The sequence BAA91771.1 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti641 – 6411R → W in BAA91892 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti538 – 5381R → C.2 Publications
Corresponds to variant rs296520 [ dbSNP | Ensembl ].
VAR_030835

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_046048Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001583 mRNA. Translation: BAA91771.1. Sequence problems.
AK001763 mRNA. Translation: BAA91892.1.
AK303885 mRNA. Translation: BAG64821.1.
AK316510 mRNA. Translation: BAH14881.1.
AC099756 Genomic DNA. No translation available.
BC106877 mRNA. Translation: AAI06878.1.
CCDSiCCDS44292.1. [Q3KP66-3]
RefSeqiNP_001136041.1. NM_001142569.2. [Q3KP66-3]
NP_060735.3. NM_018265.3.
XP_011508056.1. XM_011509754.1. [Q3KP66-3]
XP_011508057.1. XM_011509755.1. [Q3KP66-3]
UniGeneiHs.518997.

Genome annotation databases

EnsembliENST00000367342; ENSP00000356311; ENSG00000163362. [Q3KP66-1]
ENST00000413687; ENSP00000392105; ENSG00000163362. [Q3KP66-3]
GeneIDi55765.
KEGGihsa:55765.
UCSCiuc010ppm.3. human. [Q3KP66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001583 mRNA. Translation: BAA91771.1. Sequence problems.
AK001763 mRNA. Translation: BAA91892.1.
AK303885 mRNA. Translation: BAG64821.1.
AK316510 mRNA. Translation: BAH14881.1.
AC099756 Genomic DNA. No translation available.
BC106877 mRNA. Translation: AAI06878.1.
CCDSiCCDS44292.1. [Q3KP66-3]
RefSeqiNP_001136041.1. NM_001142569.2. [Q3KP66-3]
NP_060735.3. NM_018265.3.
XP_011508056.1. XM_011509754.1. [Q3KP66-3]
XP_011508057.1. XM_011509755.1. [Q3KP66-3]
UniGeneiHs.518997.

3D structure databases

ProteinModelPortaliQ3KP66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120883. 22 interactions.
IntActiQ3KP66. 1 interaction.
MINTiMINT-3976349.
STRINGi9606.ENSP00000356311.

PTM databases

iPTMnetiQ3KP66.
PhosphoSiteiQ3KP66.

Polymorphism and mutation databases

BioMutaiC1orf106.
DMDMi317373328.

Proteomic databases

EPDiQ3KP66.
MaxQBiQ3KP66.
PaxDbiQ3KP66.
PeptideAtlasiQ3KP66.
PRIDEiQ3KP66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367342; ENSP00000356311; ENSG00000163362. [Q3KP66-1]
ENST00000413687; ENSP00000392105; ENSG00000163362. [Q3KP66-3]
GeneIDi55765.
KEGGihsa:55765.
UCSCiuc010ppm.3. human. [Q3KP66-1]

Organism-specific databases

CTDi55765.
GeneCardsiC1orf106.
HGNCiHGNC:25599. C1orf106.
HPAiHPA027499.
HPA027511.
neXtProtiNX_Q3KP66.
PharmGKBiPA142672490.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
HOGENOMiHOG000233699.
HOVERGENiHBG080963.
InParanoidiQ3KP66.
OMAiWWHERAR.
OrthoDBiEOG72ZCDV.
PhylomeDBiQ3KP66.
TreeFamiTF328984.

Miscellaneous databases

ChiTaRSiC1orf106. human.
GenomeRNAii55765.
PROiQ3KP66.

Gene expression databases

BgeeiQ3KP66.
CleanExiHS_C1orf106.
ExpressionAtlasiQ3KP66. baseline and differential.
GenevisibleiQ3KP66. HS.

Family and domain databases

InterProiIPR021774. DUF3338.
[Graphical view]
PfamiPF11819. DUF3338. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT CYS-538.
    Tissue: Trachea.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-538.

Entry informationi

Entry nameiCA106_HUMAN
AccessioniPrimary (citable) accession number: Q3KP66
Secondary accession number(s): B4E1K9
, E9PFY0, Q9NV65, Q9NVI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.