Reviewed, UniProtKB/Swiss-Prot Q3KP44 (ANR55_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 55

Gene names

Name:

ANKRD55

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	613 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 9 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3KP44-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3KP44-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q3KP44-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.
     288-320: MDSNLRDINESTPLAYALYCGHTACVKLLSQES → ML

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 613	613	Ankyrin repeat domain-containing protein 55		PRO_0000274410
Regions
	Repeat	25 – 54	30	ANK 1
	Repeat	59 – 88	30	ANK 2
	Repeat	92 – 124	33	ANK 3
	Repeat	125 – 156	32	ANK 4
	Repeat	160 – 189	30	ANK 5
	Repeat	193 – 222	30	ANK 6
	Repeat	229 – 259	31	ANK 7
	Repeat	263 – 292	30	ANK 8
	Repeat	296 – 325	30	ANK 9
Natural variations
	Alternative sequence	1 – 287	287	Missing in isoform 2 and isoform 3.		VSP_022740
	Alternative sequence	288 – 320	33	MDSNL…LSQES → ML in isoform 3.		VSP_022741
	Natural variant	344	1	V → M: dbSNP rs321776. Ref.3		VAR_030283
	Natural variant	593	1	R → Q: dbSNP rs34879141.		VAR_055516

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: F0A1D4E627BF7C28	FASTA	613	68,283
	10 20 30 40 50 60 MRQATMDFST PSVFDQQRGD SSEEVDLTMV YQAASNGDVN ALTAVIREDP SILECCDSEG 70 80 90 100 110 120 CTPLMHAVSG RQADTVKLLL KMGANINMQD AYGRTSLCLA TYLGWLEGCV SLLRNGAKHN 130 140 150 160 170 180 IPDKNGRLPL HAATAEPDMR LLTVLLQQSN ISEINHQDNE GMTPLHWAAF HNQPQHTQML 190 200 210 220 230 240 LKKGADPTLV DKDFKTALHW AVQSGNRILC SIILSHHQGP SIINYDDESG KTCVHIAAAA 250 260 270 280 290 300 GFSDIIHELA RVPECNLQAL DVDDRTPLHW AAAAGKAECV QSLLELGMDS NLRDINESTP 310 320 330 340 350 360 LAYALYCGHT ACVKLLSQES RTEPTRPPPS QSSRPQKKER RFNVLNQIFC KNKKEEQRAH 370 380 390 400 410 420 QKDPSRDRYR EEDTSEVNDI ITTFDSIVGT NCQEQPGDQV AMVEFKKKTS DNSKYLLPEK 430 440 450 460 470 480 KPLARKGLPP IRTQSLPPIT LGNNFLTASH RATSHAGLSS APHHMAQRSQ KSRSEQDLLN 490 500 510 520 530 540 NRTGCQMLLD NPWKSDSNQV FSYKVWTVSS SDKLLDRLLS VRPGHQEVSV PPHLRHLHNP 550 560 570 580 590 600 SSGQNFQHLS PNRHKIRDLP FTRNNLAPLP DQKFLSGEPL RTNRVLPAIP SQRRHSTAAE 610 ESEHSANPTS DEN
	Isoform 2. Checksum: 152A2224959EA5D7	FASTA	326	36,983
	10 20 30 40 50 60 MDSNLRDINE STPLAYALYC GHTACVKLLS QESRTEPTRP PPSQSSRPQK KERRFNVLNQ 70 80 90 100 110 120 IFCKNKKEEQ RAHQKDPSRD RYREEDTSEV NDIITTFDSI VGTNCQEQPG DQVAMVEFKK 130 140 150 160 170 180 KTSDNSKYLL PEKKPLARKG LPPIRTQSLP PITLGNNFLT ASHRATSHAG LSSAPHHMAQ 190 200 210 220 230 240 RSQKSRSEQD LLNNRTGCQM LLDNPWKSDS NQVFSYKVWT VSSSDKLLDR LLSVRPGHQE 250 260 270 280 290 300 VSVPPHLRHL HNPSSGQNFQ HLSPNRHKIR DLPFTRNNLA PLPDQKFLSG EPLRTNRVLP 310 320 AIPSQRRHST AAEESEHSAN PTSDEN
	Isoform 3. Checksum: 57B698E79F5BA6C2	FASTA	295	33,602
	10 20 30 40 50 60 MLRTEPTRPP PSQSSRPQKK ERRFNVLNQI FCKNKKEEQR AHQKDPSRDR YREEDTSEVN 70 80 90 100 110 120 DIITTFDSIV GTNCQEQPGD QVAMVEFKKK TSDNSKYLLP EKKPLARKGL PPIRTQSLPP 130 140 150 160 170 180 ITLGNNFLTA SHRATSHAGL SSAPHHMAQR SQKSRSEQDL LNNRTGCQML LDNPWKSDSN 190 200 210 220 230 240 QVFSYKVWTV SSSDKLLDRL LSVRPGHQEV SVPPHLRHLH NPSSGQNFQH LSPNRHKIRD 250 260 270 280 290 LPFTRNNLAP LPDQKFLSGE PLRTNRVLPA IPSQRRHSTA AEESEHSANP TSDEN

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Embryo.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-344.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK021857 mRNA. Translation: BAB13916.1. AC016585 Genomic DNA. No translation available. AC016638 Genomic DNA. No translation available. BC106914 mRNA. Translation: AAI06915.1. BC106915 mRNA. Translation: AAI06916.1.
IPI	IPI00002928. IPI00413655. IPI00827545.
RefSeq	NP_001035024.1. NP_078945.2.
UniGene	Hs.436214
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q3KP44.
Genome annotation databases
Ensembl	ENST00000341048; ENSP00000342295; ENSG00000164512; Homo sapiens. [Genome view]
GeneID	79722.
KEGG	hsa:79722.
NMPDR	fig|9606.3.peg.25265.
UCSC	uc003jqt.1. human.
Organism-specific databases
CTD	79722.
GeneCards	GC05M055432.
HGNC	HGNC:25681. ANKRD55.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q3KP44.
OMA	PLAYALY
Gene expression databases
ArrayExpress	Q3KP44.
Bgee	Q3KP44.
CleanEx	HS_ANKRD55.
Genevestigator	Q3KP44.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 8 hits. [Graphical view]
SMART	SM00248. ANK. 9 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69076.

Entry information

Entry name

ANR55_HUMAN

Accession

Primary (citable) accession number: Q3KP44
Secondary accession number(s): Q3KP45, Q9HAD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	November 24, 2009
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.