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Protein

Zinc finger protein 791

Gene

ZNF791

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri100 – 12223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 791
Gene namesi
Name:ZNF791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26895. ZNF791.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410522.

Polymorphism and mutation databases

BioMutaiZNF791.
DMDMi121942546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Zinc finger protein 791PRO_0000311799Add
BLAST

Proteomic databases

EPDiQ3KP31.
MaxQBiQ3KP31.
PaxDbiQ3KP31.
PeptideAtlasiQ3KP31.
PRIDEiQ3KP31.

PTM databases

iPTMnetiQ3KP31.
PhosphoSiteiQ3KP31.

Expressioni

Gene expression databases

BgeeiQ3KP31.
CleanExiHS_ZNF791.
ExpressionAtlasiQ3KP31. baseline and differential.
GenevisibleiQ3KP31. HS.

Organism-specific databases

HPAiHPA021537.

Interactioni

Protein-protein interaction databases

BioGridi127843. 2 interactions.
IntActiQ3KP31. 1 interaction.
STRINGi9606.ENSP00000342974.

Structurei

3D structure databases

ProteinModelPortaliQ3KP31.
SMRiQ3KP31. Positions 4-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9087KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri100 – 12223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3KP31.
KOiK09228.
OMAiSHTGYEL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3KP31.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KP31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVAFEDVS VSFSQEEWAL LAPSQKKLYR DVMQETFKNL ASIGEKWEDP
60 70 80 90 100
NVEDQHKNQG RNLRSHTGER LCEGKEGSQC AENFSPNLSV TKKTAGVKPY
110 120 130 140 150
ECTICGKAFM RLSSLTRHMR SHTGYELFEK PYKCKECEKA FSYLKSFQRH
160 170 180 190 200
ERSHTGEKPY KCKQCGKTFI YHQPFQRHER THIGEKPYEC KQCGKALSCS
210 220 230 240 250
SSLRVHERIH TGEKPYECKQ CGKAFSCSSS IRVHERTHTG EKPYACKECG
260 270 280 290 300
KAFISHTSVL THMITHNGDR PYKCKECGKA FIFPSFLRVH ERIHTGEKPY
310 320 330 340 350
KCKQCGKAFR CSTSIQIHER IHTGEKPYKC KECGKSFSAR PAFRVHVRVH
360 370 380 390 400
TGEKPYKCKE CGKAFSRISY FRIHERTHTG EKPYECKKCG KTFNYPLDLK
410 420 430 440 450
IHKRNHTGEK PYECKECAKT FISLENFRRH MITHTGDGPY KCRDCGKVFI
460 470 480 490 500
FPSALRTHER THTGEKPYEC KQCGKAFSCS SYIRIHKRTH TGEKPYECKE
510 520 530 540 550
CGKAFIYPTS FQGHMRMHTG EKPYKCKECG KAFSLHSSFQ RHTRIHNYEK
560 570
PLECKQCGKA FSVSTSLKKH MRMHNR
Length:576
Mass (Da):66,872
Last modified:November 8, 2005 - v1
Checksum:i5F6FD2569DAABD43
GO
Isoform 2 (identifier: Q3KP31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):63,214
Checksum:iD0CA2452C2FA2EB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771R → S in BAC11261 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_056674Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074877 mRNA. Translation: BAC11261.1.
AK298597 mRNA. Translation: BAH12822.1.
CH471106 Genomic DNA. Translation: EAW84278.1.
BC106937 mRNA. Translation: AAI06938.1.
BC106938 mRNA. Translation: AAI06939.1.
CCDSiCCDS12273.1. [Q3KP31-1]
RefSeqiNP_699189.2. NM_153358.2. [Q3KP31-1]
UniGeneiHs.720677.

Genome annotation databases

EnsembliENST00000343325; ENSP00000342974; ENSG00000173875. [Q3KP31-1]
GeneIDi163049.
KEGGihsa:163049.
UCSCiuc002mua.3. human. [Q3KP31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074877 mRNA. Translation: BAC11261.1.
AK298597 mRNA. Translation: BAH12822.1.
CH471106 Genomic DNA. Translation: EAW84278.1.
BC106937 mRNA. Translation: AAI06938.1.
BC106938 mRNA. Translation: AAI06939.1.
CCDSiCCDS12273.1. [Q3KP31-1]
RefSeqiNP_699189.2. NM_153358.2. [Q3KP31-1]
UniGeneiHs.720677.

3D structure databases

ProteinModelPortaliQ3KP31.
SMRiQ3KP31. Positions 4-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127843. 2 interactions.
IntActiQ3KP31. 1 interaction.
STRINGi9606.ENSP00000342974.

PTM databases

iPTMnetiQ3KP31.
PhosphoSiteiQ3KP31.

Polymorphism and mutation databases

BioMutaiZNF791.
DMDMi121942546.

Proteomic databases

EPDiQ3KP31.
MaxQBiQ3KP31.
PaxDbiQ3KP31.
PeptideAtlasiQ3KP31.
PRIDEiQ3KP31.

Protocols and materials databases

DNASUi163049.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343325; ENSP00000342974; ENSG00000173875. [Q3KP31-1]
GeneIDi163049.
KEGGihsa:163049.
UCSCiuc002mua.3. human. [Q3KP31-1]

Organism-specific databases

CTDi163049.
GeneCardsiZNF791.
HGNCiHGNC:26895. ZNF791.
HPAiHPA021537.
neXtProtiNX_Q3KP31.
PharmGKBiPA162410522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3KP31.
KOiK09228.
OMAiSHTGYEL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3KP31.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF791. human.
GenomeRNAii163049.
PROiQ3KP31.

Gene expression databases

BgeeiQ3KP31.
CleanExiHS_ZNF791.
ExpressionAtlasiQ3KP31. baseline and differential.
GenevisibleiQ3KP31. HS.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiZN791_HUMAN
AccessioniPrimary (citable) accession number: Q3KP31
Secondary accession number(s): B7Z586, Q8NC99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 8, 2005
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.