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Q3KNZ4

- Q3KNZ4_MOUSE

UniProt

Q3KNZ4 - Q3KNZ4_MOUSE

Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.UniRule annotation

    GO - Molecular functioni

    1. vasopressin receptor activity Source: InterPro

    GO - Biological processi

    1. I-kappaB kinase/NF-kappaB signaling Source: MGI
    2. interferon-gamma production Source: MGI
    3. response to cytokine Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V2 receptorUniRule annotation
    Gene namesi
    Name:Avpr2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:88123. Avpr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    GlycoproteinUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ3KNZ4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00660000095384.
    KOiK04228.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000161. Vprsn_rcpt_V2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00898. VASOPRSNV2R.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3KNZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILVSTTSGI AACQVLIFRE IHASLVPGPS ERAGRRRRGH RTGSPSEGAH    50
    VSAAMAKTVR MTLVIVIVYV LCWAPFFLVQ LWAAWDPEAP LERPPFVLLM 100
    LLASLNSCTN PWIYASFSSS VSSELRSLLC CAQRHTTHSL GPQDESCATA 150
    SSSLMKDTPS 160
    Length:160
    Mass (Da):17,371
    Last modified:November 8, 2005 - v1
    Checksum:iF003C288F02FD59B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672002 Genomic DNA. No translation available.
    BC107005 mRNA. Translation: AAI07006.1.
    RefSeqiNP_001263228.1. NM_001276299.1.
    UniGeneiMm.383171.

    Genome annotation databases

    EnsembliENSMUST00000114395; ENSMUSP00000110037; ENSMUSG00000031390.
    GeneIDi12000.
    KEGGimmu:12000.
    UCSCiuc012hki.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672002 Genomic DNA. No translation available.
    BC107005 mRNA. Translation: AAI07006.1 .
    RefSeqi NP_001263228.1. NM_001276299.1.
    UniGenei Mm.383171.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114395 ; ENSMUSP00000110037 ; ENSMUSG00000031390 .
    GeneIDi 12000.
    KEGGi mmu:12000.
    UCSCi uc012hki.1. mouse.

    Organism-specific databases

    CTDi 554.
    MGIi MGI:88123. Avpr2.

    Phylogenomic databases

    GeneTreei ENSGT00660000095384.
    KOi K04228.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3KNZ4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000161. Vprsn_rcpt_V2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00898. VASOPRSNV2R.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3KNZ4_MOUSE
    AccessioniPrimary (citable) accession number: Q3KNZ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3