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Protein

Solute carrier family 10 member 6

Gene

SLC10A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.28.1.4. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 10 member 6
Alternative name(s):
Sodium-dependent organic anion transporter
Gene namesi
Name:SLC10A6
Synonyms:SOAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30603. SLC10A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 67CytoplasmicSequence analysisAdd BLAST17
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 97ExtracellularSequence analysis9
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 133CytoplasmicSequence analysisAdd BLAST15
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 159ExtracellularSequence analysis5
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 195CytoplasmicSequence analysisAdd BLAST15
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 226ExtracellularSequence analysis10
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 266CytoplasmicSequence analysisAdd BLAST19
Transmembranei267 – 285HelicalSequence analysisAdd BLAST19
Topological domaini286 – 290ExtracellularSequence analysis5
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 377CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi345274.
OpenTargetsiENSG00000145283.
PharmGKBiPA142670910.

Polymorphism and mutation databases

BioMutaiSLC10A6.
DMDMi160358735.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092151 – 377Solute carrier family 10 member 6Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3KNW5.
PeptideAtlasiQ3KNW5.
PRIDEiQ3KNW5.

Expressioni

Tissue specificityi

Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000145283.
CleanExiHS_SLC10A6.

Organism-specific databases

HPAiHPA016662.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273905.

Structurei

3D structure databases

ProteinModelPortaliQ3KNW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiQ3KNW5.
KOiK14346.
OMAiCLTIPVA.
OrthoDBiEOG091G0GT5.
PhylomeDBiQ3KNW5.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030203. SLC10A6.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF4. PTHR10361:SF4. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG
60 70 80 90 100
CSVEIRKLWS HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV
110 120 130 140 150
LIMGCCPGGT ISNIFTFWVD GDMDLSISMT TCSTVAALGM MPLCIYLYTW
160 170 180 190 200
SWSLQQNLTI PYQNIGITLV CLTIPVAFGV YVNYRWPKQS KIILKIGAVV
210 220 230 240 250
GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT GFLLALFTHQ
260 270 280 290 300
SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID
310 320 330 340 350
GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE
360 370
GAITPGPPGP MDCHRALEPV GHITSCE
Length:377
Mass (Da):41,259
Last modified:November 13, 2007 - v2
Checksum:iA68B0F034B5BE83F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0369046S → F.Corresponds to variant rs17694522dbSNPEnsembl.1
Natural variantiVAR_036905114I → V.1 PublicationCorresponds to variant rs13106574dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437223 mRNA. Translation: ABO38126.1.
AJ583502 mRNA. Translation: CAE47477.1.
CH471057 Genomic DNA. Translation: EAX05969.1.
BC107051 mRNA. Translation: AAI07052.1.
BC107052 mRNA. Translation: AAI07053.1.
CCDSiCCDS3614.1.
RefSeqiNP_932069.1. NM_197965.2.
UniGeneiHs.452996.

Genome annotation databases

EnsembliENST00000273905; ENSP00000273905; ENSG00000145283.
GeneIDi345274.
KEGGihsa:345274.
UCSCiuc003hqd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437223 mRNA. Translation: ABO38126.1.
AJ583502 mRNA. Translation: CAE47477.1.
CH471057 Genomic DNA. Translation: EAX05969.1.
BC107051 mRNA. Translation: AAI07052.1.
BC107052 mRNA. Translation: AAI07053.1.
CCDSiCCDS3614.1.
RefSeqiNP_932069.1. NM_197965.2.
UniGeneiHs.452996.

3D structure databases

ProteinModelPortaliQ3KNW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000273905.

Protein family/group databases

TCDBi2.A.28.1.4. the bile acid:na(+) symporter (bass) family.

Polymorphism and mutation databases

BioMutaiSLC10A6.
DMDMi160358735.

Proteomic databases

PaxDbiQ3KNW5.
PeptideAtlasiQ3KNW5.
PRIDEiQ3KNW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273905; ENSP00000273905; ENSG00000145283.
GeneIDi345274.
KEGGihsa:345274.
UCSCiuc003hqd.2. human.

Organism-specific databases

CTDi345274.
DisGeNETi345274.
GeneCardsiSLC10A6.
HGNCiHGNC:30603. SLC10A6.
HPAiHPA016662.
MIMi613366. gene.
neXtProtiNX_Q3KNW5.
OpenTargetsiENSG00000145283.
PharmGKBiPA142670910.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiQ3KNW5.
KOiK14346.
OMAiCLTIPVA.
OrthoDBiEOG091G0GT5.
PhylomeDBiQ3KNW5.
TreeFamiTF315811.

Enzyme and pathway databases

ReactomeiR-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

GenomeRNAii345274.
PROiQ3KNW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145283.
CleanExiHS_SLC10A6.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030203. SLC10A6.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF4. PTHR10361:SF4. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSOAT_HUMAN
AccessioniPrimary (citable) accession number: Q3KNW5
Secondary accession number(s): Q70EX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.