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Protein

Zinc finger protein SNAI3

Gene

SNAI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri183 – 20523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI3
Alternative name(s):
Protein snail homolog 3
Zinc finger protein 293
Gene namesi
Name:SNAI3
Synonyms:ZNF293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18411. SNAI3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988226.

Polymorphism and mutation databases

BioMutaiSNAI3.
DMDMi121942538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Zinc finger protein SNAI3PRO_0000330037Add
BLAST

Proteomic databases

EPDiQ3KNW1.
PaxDbiQ3KNW1.
PRIDEiQ3KNW1.

Expressioni

Gene expression databases

BgeeiQ3KNW1.
CleanExiHS_SNAI3.
GenevisibleiQ3KNW1. HS.

Organism-specific databases

HPAiHPA016757.

Interactioni

Protein-protein interaction databases

BioGridi130614. 6 interactions.
IntActiQ3KNW1. 3 interactions.
STRINGi9606.ENSP00000327968.

Structurei

3D structure databases

ProteinModelPortaliQ3KNW1.
SMRiQ3KNW1. Positions 152-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Domaini

Binds E-box via C2H2-type zinc finger domain.By similarity

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri183 – 20523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ3KNW1.
KOiK09217.
OMAiTHTLPCT.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ3KNW1.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR002355. Cu_oxidase_Cu_BS.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KNW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS
60 70 80 90 100
VPGDLPQPWD RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA
110 120 130 140 150
AIVPLKDSLN HLNLPPLLVL PTRWSPTLGP DRHGAPEKLL GAERMPRAPG
160 170 180 190 200
GFECFHCHKP YHTLAGLARH RQLHCHLQVG RVFTCKYCDK EYTSLGALKM
210 220 230 240 250
HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS HCSRAFADRS
260 270 280 290
NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GP
Length:292
Mass (Da):32,474
Last modified:November 8, 2005 - v1
Checksum:iCF9853C07029621F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA. Translation: EAW66765.1.
BC041461 mRNA. Translation: AAH41461.1.
BC107058 mRNA. Translation: AAI07059.1.
CCDSiCCDS32505.1.
RefSeqiNP_840101.1. NM_178310.3.
UniGeneiHs.673548.

Genome annotation databases

EnsembliENST00000332281; ENSP00000327968; ENSG00000185669.
GeneIDi333929.
KEGGihsa:333929.
UCSCiuc002flj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA. Translation: EAW66765.1.
BC041461 mRNA. Translation: AAH41461.1.
BC107058 mRNA. Translation: AAI07059.1.
CCDSiCCDS32505.1.
RefSeqiNP_840101.1. NM_178310.3.
UniGeneiHs.673548.

3D structure databases

ProteinModelPortaliQ3KNW1.
SMRiQ3KNW1. Positions 152-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130614. 6 interactions.
IntActiQ3KNW1. 3 interactions.
STRINGi9606.ENSP00000327968.

Polymorphism and mutation databases

BioMutaiSNAI3.
DMDMi121942538.

Proteomic databases

EPDiQ3KNW1.
PaxDbiQ3KNW1.
PRIDEiQ3KNW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332281; ENSP00000327968; ENSG00000185669.
GeneIDi333929.
KEGGihsa:333929.
UCSCiuc002flj.4. human.

Organism-specific databases

CTDi333929.
GeneCardsiSNAI3.
HGNCiHGNC:18411. SNAI3.
HPAiHPA016757.
MIMi612741. gene.
neXtProtiNX_Q3KNW1.
PharmGKBiPA134988226.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ3KNW1.
KOiK09217.
OMAiTHTLPCT.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ3KNW1.
TreeFamiTF315515.

Miscellaneous databases

GenomeRNAii333929.
NextBioi96738.
PROiQ3KNW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3KNW1.
CleanExiHS_SNAI3.
GenevisibleiQ3KNW1. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR002355. Cu_oxidase_Cu_BS.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSNAI3_HUMAN
AccessioniPrimary (citable) accession number: Q3KNW1
Secondary accession number(s): Q86SU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 8, 2005
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.