Q3KNV8 (PCGF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 58.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Polycomb group RING finger protein 3 Alternative name(s): RING finger protein 3A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Subunit structure | Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. Ref.4 |
| Subcellular location | |
| Sequence similarities | Contains 1 RING-type zinc finger. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Repressor |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | PcG protein complex Inferred from direct assay Ref.4. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction Ref.4. Source: IntAct zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CBX6 | O95503 | 2 | EBI-2339807,EBI-3951758 | |
| CBX7 | O95931 | 2 | EBI-2339807,EBI-3923843 | |
| CBX8 | Q9HC52 | 3 | EBI-2339807,EBI-712912 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q3KNV8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q3KNV8-2) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MEFPKM |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Interactions of the BCL7A protein with novel ring finger proteins." Abdul-Rauf M., Dyer M.J. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). |
| [2] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [4] | "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells." Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O. Mol. Cell. Proteomics 0:0-0(2011) [PubMed: 21282530] [Abstract] Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH CBX6; CBX7 AND CBX8. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ001019 mRNA. Translation: CAA04477.1. CH471131 Genomic DNA. Translation: EAW82652.1. CH471131 Genomic DNA. Translation: EAW82653.1. CH471131 Genomic DNA. Translation: EAW82656.1. BC107061 mRNA. Translation: AAI07062.1. |
| IPI | IPI00007279. IPI00827991. |
| RefSeq | NP_006306.2. NM_006315.4. |
| UniGene | Hs.144309. Hs.707307. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2CKL based on UniProtKB P25916. |
| ProteinModelPortal | Q3KNV8. |
| SMR | Q3KNV8. Positions 3-100, 154-236. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q3KNV8. 4 interactions. |
| STRING | Q3KNV8. |
PTM databases | |
| PhosphoSite | Q3KNV8. |
Polymorphism databases | |
| DMDM | 121942537. |
Proteomic databases | |
| PRIDE | Q3KNV8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000362003; ENSP00000354724; ENSG00000185619. ENST00000470161; ENSP00000420489; ENSG00000185619. |
| GeneID | 10336. |
| KEGG | hsa:10336. |
| UCSC | uc003gbe.1. human. uc003gbg.1. human. |
Organism-specific databases | |
| CTD | 10336. |
| GeneCards | GC04P000691. |
| HGNC | HGNC:10066. PCGF3. |
| HPA | HPA018487. |
| neXtProt | NX_Q3KNV8. |
| PharmGKB | PA34433. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG04749. |
| GeneTree | ENSGT00550000074463. |
| HOVERGEN | HBG052826. |
| InParanoid | Q3KNV8. |
| OMA | HRNGETK. |
| OrthoDB | EOG49ZXPZ. |
| PhylomeDB | Q3KNV8. |
Gene expression databases | |
| ArrayExpress | Q3KNV8. |
| Bgee | Q3KNV8. |
| CleanEx | HS_PCGF3. |
| Genevestigator | Q3KNV8. |
Family and domain databases | |
| InterPro | IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view] |
| Gene3D | G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. |
| KO | K11488. |
| Pfam | PF00097. zf-C3HC4. 1 hit. [Graphical view] |
| SMART | SM00184. RING. 1 hit. [Graphical view] |
| PROSITE | PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 39203. |
Entry information
| Entry name | PCGF3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q3KNV8 Secondary accession number(s): D3DVN1, O15262 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with