Reviewed,
UniProtKB/Swiss-Prot Q3KNV8 (PCGF3_HUMAN)
Last modified
June 16, 2009.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Polycomb group RING finger protein 3 Alternative name(s): RING finger protein 3A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Probable component of some Polycomb group (PcG) multiprotein complex, a complex required to maintain the transcriptionally repressive state of some genes By similarity. |
| Sequence similarities | Contains 1 RING-type zinc finger. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Coding sequence diversity | Alternative splicing |
| Domain | Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Repressor |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q3KNV8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q3KNV8-2) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MEFPKM |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Interactions of the BCL7A protein with novel ring finger proteins." Abdul-Rauf M., Dyer M.J. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
Cross-references
Sequence databases | |
|---|---|
| AJ001019 mRNA. Translation: CAA04477.1. BC107061 mRNA. Translation: AAI07062.1. | |
| IPI | IPI00007279. IPI00827991. |
| RefSeq | NP_006306.2. |
| UniGene | Hs.144309 Hs.707307 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q3KNV8. |
Genome annotation databases | |
| Ensembl | ENSG00000185619. Homo sapiens. [Contig view] |
| GeneID | 10336. |
| KEGG | hsa:10336. |
Organism-specific databases | |
| GeneCards | GC04P000691. |
| HGNC | HGNC:10066. PCGF3. |
| HPA | HPA018487. |
| PharmGKB | PA34433. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q3KNV8. |
| OMA | Q3KNV8. YISFDRT. |
Gene expression databases | |
| ArrayExpress | Q3KNV8. |
| Bgee | Q3KNV8. |
| CleanEx | HS_PCGF3. |
Family and domain databases | |
| InterPro | IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view] |
| Pfam | PF00097. zf-C3HC4. 1 hit. [Graphical view] |
| SMART | SM00184. RING. 1 hit. [Graphical view] |
| PROSITE | PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 39203. |
Entry information
| Entry name | PCGF3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q3KNV8 Secondary accession number(s): O15262 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


