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Protein

Polycomb group RING finger protein 3

Gene

PCGF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 56RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 3
Alternative name(s):
RING finger protein 3A
Gene namesi
Name:PCGF3
Synonyms:RNF3, RNF3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10066. PCGF3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10336.
OpenTargetsiENSG00000185619.
PharmGKBiPA34433.

Polymorphism and mutation databases

BioMutaiPCGF3.
DMDMi121942537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778641 – 242Polycomb group RING finger protein 3Add BLAST242

Proteomic databases

EPDiQ3KNV8.
MaxQBiQ3KNV8.
PaxDbiQ3KNV8.
PeptideAtlasiQ3KNV8.
PRIDEiQ3KNV8.

PTM databases

iPTMnetiQ3KNV8.
PhosphoSitePlusiQ3KNV8.

Expressioni

Gene expression databases

BgeeiENSG00000185619.
CleanExiHS_PCGF3.
ExpressionAtlasiQ3KNV8. baseline and differential.
GenevisibleiQ3KNV8. HS.

Organism-specific databases

HPAiHPA018487.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCORQ6W2J9-43EBI-2339807,EBI-10208579
CBX6O955032EBI-2339807,EBI-3951758
CBX7O959312EBI-2339807,EBI-3923843
CBX8Q9HC524EBI-2339807,EBI-712912
PHC2Q8IXK03EBI-2339807,EBI-713786
RING1Q065874EBI-2339807,EBI-752313
RNF2Q994964EBI-2339807,EBI-722416

Protein-protein interaction databases

BioGridi115618. 29 interactors.
DIPiDIP-52782N.
IntActiQ3KNV8. 34 interactors.
STRINGi9606.ENSP00000354724.

Structurei

3D structure databases

ProteinModelPortaliQ3KNV8.
SMRiQ3KNV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 56RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOVERGENiHBG052826.
InParanoidiQ3KNV8.
KOiK11488.
OMAiYRPRIDI.
OrthoDBiEOG091G0EC9.
PhylomeDBiQ3KNV8.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KNV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN
60 70 80 90 100
TCPTCRIVIH QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL
110 120 130 140 150
GMEVPGDIKG ETCSAKQHLD SHRNGETKAD DSSNKEAAEE KPEEDNDYHR
160 170 180 190 200
SDEQVSICLE CNSSKLRGLK RKWIRCSAQA TVLHLKKFIA KKLNLSSFNE
210 220 230 240
LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD LL
Length:242
Mass (Da):28,115
Last modified:November 8, 2005 - v1
Checksum:i202A607F571B249C
GO
Isoform 2 (identifier: Q3KNV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEFPKM

Show »
Length:247
Mass (Da):28,748
Checksum:iAFA425732644EF8A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231151M → MEFPKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001019 mRNA. Translation: CAA04477.1.
CH471131 Genomic DNA. Translation: EAW82652.1.
CH471131 Genomic DNA. Translation: EAW82653.1.
CH471131 Genomic DNA. Translation: EAW82656.1.
BC107061 mRNA. Translation: AAI07062.1.
CCDSiCCDS3339.2. [Q3KNV8-1]
RefSeqiNP_001304765.1. NM_001317836.1. [Q3KNV8-1]
NP_006306.2. NM_006315.5. [Q3KNV8-1]
UniGeneiHs.144309.
Hs.731755.

Genome annotation databases

EnsembliENST00000362003; ENSP00000354724; ENSG00000185619. [Q3KNV8-1]
ENST00000470161; ENSP00000420489; ENSG00000185619. [Q3KNV8-1]
GeneIDi10336.
KEGGihsa:10336.
UCSCiuc003gbe.4. human. [Q3KNV8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001019 mRNA. Translation: CAA04477.1.
CH471131 Genomic DNA. Translation: EAW82652.1.
CH471131 Genomic DNA. Translation: EAW82653.1.
CH471131 Genomic DNA. Translation: EAW82656.1.
BC107061 mRNA. Translation: AAI07062.1.
CCDSiCCDS3339.2. [Q3KNV8-1]
RefSeqiNP_001304765.1. NM_001317836.1. [Q3KNV8-1]
NP_006306.2. NM_006315.5. [Q3KNV8-1]
UniGeneiHs.144309.
Hs.731755.

3D structure databases

ProteinModelPortaliQ3KNV8.
SMRiQ3KNV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115618. 29 interactors.
DIPiDIP-52782N.
IntActiQ3KNV8. 34 interactors.
STRINGi9606.ENSP00000354724.

PTM databases

iPTMnetiQ3KNV8.
PhosphoSitePlusiQ3KNV8.

Polymorphism and mutation databases

BioMutaiPCGF3.
DMDMi121942537.

Proteomic databases

EPDiQ3KNV8.
MaxQBiQ3KNV8.
PaxDbiQ3KNV8.
PeptideAtlasiQ3KNV8.
PRIDEiQ3KNV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362003; ENSP00000354724; ENSG00000185619. [Q3KNV8-1]
ENST00000470161; ENSP00000420489; ENSG00000185619. [Q3KNV8-1]
GeneIDi10336.
KEGGihsa:10336.
UCSCiuc003gbe.4. human. [Q3KNV8-1]

Organism-specific databases

CTDi10336.
DisGeNETi10336.
GeneCardsiPCGF3.
HGNCiHGNC:10066. PCGF3.
HPAiHPA018487.
neXtProtiNX_Q3KNV8.
OpenTargetsiENSG00000185619.
PharmGKBiPA34433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOVERGENiHBG052826.
InParanoidiQ3KNV8.
KOiK11488.
OMAiYRPRIDI.
OrthoDBiEOG091G0EC9.
PhylomeDBiQ3KNV8.
TreeFamiTF324206.

Miscellaneous databases

ChiTaRSiPCGF3. human.
GenomeRNAii10336.
PROiQ3KNV8.

Gene expression databases

BgeeiENSG00000185619.
CleanExiHS_PCGF3.
ExpressionAtlasiQ3KNV8. baseline and differential.
GenevisibleiQ3KNV8. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCGF3_HUMAN
AccessioniPrimary (citable) accession number: Q3KNV8
Secondary accession number(s): D3DVN1, O15262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.