Reviewed, UniProtKB/Swiss-Prot Q3KNV8 (PCGF3_HUMAN)

Names and origin

Protein names

Recommended name:
    Polycomb group RING finger protein 3
Alternative name(s):
    RING finger protein 3A

Gene names

Name:	PCGF3
Synonyms:	RNF3, RNF3A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable component of some Polycomb group (PcG) multiprotein complex, a complex required to maintain the transcriptionally repressive state of some genes By similarity.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Repressor
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3KNV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3KNV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEFPKM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Polycomb group RING finger protein 3		PRO_0000277864
Regions
	Zinc finger	17 – 56	40	RING-type
Natural variations
	Alternative sequence	1	1	M → MEFPKM in isoform 2.		VSP_023115

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 202A607F571B249C	FASTA	242	28,115
	10 20 30 40 50 60 MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH 70 80 90 100 110 120 QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD 130 140 150 160 170 180 SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA 190 200 210 220 230 240 TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD LL
	Isoform 2. Checksum: AFA425732644EF8A	FASTA	247	28,748
	10 20 30 40 50 60 MEFPKMLTRK IKLWDINAHI TCRLCSGYLI DATTVTECLH TFCRSCLVKY LEENNTCPTC 70 80 90 100 110 120 RIVIHQSHPL QYIGHDRTMQ DIVYKLVPGL QEAEMRKQRE FYHKLGMEVP GDIKGETCSA 130 140 150 160 170 180 KQHLDSHRNG ETKADDSSNK EAAEEKPEED NDYHRSDEQV SICLECNSSK LRGLKRKWIR 190 200 210 220 230 240 CSAQATVLHL KKFIAKKLNL SSFNELDILC NEEILGKDHT LKFVVVTRWR FKKAPLLLHY RPKMDLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interactions of the BCL7A protein with novel ring finger proteins." Abdul-Rauf M., Dyer M.J. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ001019 mRNA. Translation: CAA04477.1. BC107061 mRNA. Translation: AAI07062.1.
IPI	IPI00007279. IPI00827991.
RefSeq	NP_006306.2.
UniGene	Hs.144309 Hs.707307
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q3KNV8.
Genome annotation databases
Ensembl	ENSG00000185619. Homo sapiens. [Contig view]
GeneID	10336.
KEGG	hsa:10336.
Organism-specific databases
GeneCards	GC04P000691.
HGNC	HGNC:10066. PCGF3.
HPA	HPA018487.
PharmGKB	PA34433.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q3KNV8.
OMA	Q3KNV8. YISFDRT.
Gene expression databases
ArrayExpress	Q3KNV8.
Bgee	Q3KNV8.
CleanEx	HS_PCGF3.
Family and domain databases
InterPro	IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00097. zf-C3HC4. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	39203.

Entry information

Entry name

PCGF3_HUMAN

Accession

Primary (citable) accession number: Q3KNV8
Secondary accession number(s): O15262

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 8, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)