Q3KNV8 (PCGF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polycomb group RING finger protein 3

Alternative name(s):
RING finger protein 3A

Gene names

Name:	PCGF3
Synonyms:	RNF3, RNF3A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Subunit structure	Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. Ref.4
Subcellular location	Nucleus Ref.4.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	PcG protein complex Inferred from direct assay Ref.4. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.4. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CBX6	O95503	2	EBI-2339807,EBI-3951758
CBX7	O95931	2	EBI-2339807,EBI-3923843
CBX8	Q9HC52	3	EBI-2339807,EBI-712912

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3KNV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3KNV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEFPKM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Polycomb group RING finger protein 3		PRO_0000277864
Regions
	Zinc finger	17 – 56	40	RING-type
Natural variations
	Alternative sequence	1	1	M → MEFPKM in isoform 2.		VSP_023115

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 202A607F571B249C	FASTA	242	28,115
	10 20 30 40 50 60 MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH 70 80 90 100 110 120 QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD 130 140 150 160 170 180 SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA 190 200 210 220 230 240 TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD LL
	Isoform 2 [UniParc]. Checksum: AFA425732644EF8A	FASTA	247	28,748
	10 20 30 40 50 60 MEFPKMLTRK IKLWDINAHI TCRLCSGYLI DATTVTECLH TFCRSCLVKY LEENNTCPTC 70 80 90 100 110 120 RIVIHQSHPL QYIGHDRTMQ DIVYKLVPGL QEAEMRKQRE FYHKLGMEVP GDIKGETCSA 130 140 150 160 170 180 KQHLDSHRNG ETKADDSSNK EAAEEKPEED NDYHRSDEQV SICLECNSSK LRGLKRKWIR 190 200 210 220 230 240 CSAQATVLHL KKFIAKKLNL SSFNELDILC NEEILGKDHT LKFVVVTRWR FKKAPLLLHY RPKMDLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interactions of the BCL7A protein with novel ring finger proteins." Abdul-Rauf M., Dyer M.J. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells." Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O. Mol. Cell. Proteomics 0:0-0(2011) [PubMed: 21282530] [Abstract] Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH CBX6; CBX7 AND CBX8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001019 mRNA. Translation: CAA04477.1. CH471131 Genomic DNA. Translation: EAW82652.1. CH471131 Genomic DNA. Translation: EAW82653.1. CH471131 Genomic DNA. Translation: EAW82656.1. BC107061 mRNA. Translation: AAI07062.1.
IPI	IPI00007279. IPI00827991.
RefSeq	NP_006306.2. NM_006315.4.
UniGene	Hs.144309. Hs.707307.
3D structure databases
HSSP	HSSP built from PDB template 2CKL based on UniProtKB P25916.
ProteinModelPortal	Q3KNV8.
SMR	Q3KNV8. Positions 3-100, 154-236.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3KNV8. 4 interactions.
STRING	Q3KNV8.
PTM databases
PhosphoSite	Q3KNV8.
Polymorphism databases
DMDM	121942537.
Proteomic databases
PRIDE	Q3KNV8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000362003; ENSP00000354724; ENSG00000185619. ENST00000470161; ENSP00000420489; ENSG00000185619.
GeneID	10336.
KEGG	hsa:10336.
UCSC	uc003gbe.1. human. uc003gbg.1. human.
Organism-specific databases
CTD	10336.
GeneCards	GC04P000691.
HGNC	HGNC:10066. PCGF3.
HPA	HPA018487.
neXtProt	NX_Q3KNV8.
PharmGKB	PA34433.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04749.
GeneTree	ENSGT00550000074463.
HOVERGEN	HBG052826.
InParanoid	Q3KNV8.
OMA	HRNGETK.
OrthoDB	EOG49ZXPZ.
PhylomeDB	Q3KNV8.
Gene expression databases
ArrayExpress	Q3KNV8.
Bgee	Q3KNV8.
CleanEx	HS_PCGF3.
Genevestigator	Q3KNV8.
Family and domain databases
InterPro	IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KO	K11488.
Pfam	PF00097. zf-C3HC4. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	39203.

Entry information

Entry name

PCGF3_HUMAN

Accession

Primary (citable) accession number: Q3KNV8
Secondary accession number(s): D3DVN1, O15262

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 8, 2005
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.