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Protein

Zinc finger protein 829

Gene

ZNF829

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 829
Gene namesi
Name:ZNF829
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34032. ZNF829.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi374899.
OpenTargetsiENSG00000185869.
PharmGKBiPA162410750.

Polymorphism and mutation databases

BioMutaiZNF829.
DMDMi121947691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003358081 – 432Zinc finger protein 829Add BLAST432

Proteomic databases

MaxQBiQ3KNS6.
PaxDbiQ3KNS6.
PeptideAtlasiQ3KNS6.
PRIDEiQ3KNS6.

PTM databases

iPTMnetiQ3KNS6.
PhosphoSitePlusiQ3KNS6.

Expressioni

Gene expression databases

BgeeiENSG00000185869.
CleanExiHS_ZNF829.
GenevisibleiQ3KNS6. HS.

Interactioni

Protein-protein interaction databases

BioGridi131934. 8 interactors.
IntActiQ3KNS6. 5 interactors.
MINTiMINT-8417749.
STRINGi9606.ENSP00000429266.

Structurei

3D structure databases

ProteinModelPortaliQ3KNS6.
SMRiQ3KNS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 106KRABPROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 20Poly-Glu4

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3KNS6.
KOiK09228.
OMAiMFRDVSI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3KNS6.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KNS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHSPLISIP HVWCHPEEEE RMHDELLQAV SKGPVMFRDV SIDFSQEEWE
60 70 80 90 100
CLDADQMNLY KEVMLENFSN LVSVGLSNSK PAVISLLEQG KEPWMVDREL
110 120 130 140 150
TRGLCSDLES MCETKILSLK KRHFSQVIIT REDMSTFIQP TFLIPPQKTM
160 170 180 190 200
SEEKPWECKI CGKTFNQNSQ FIQHQRIHFG EKHYESKEYG KSFSRGSLVT
210 220 230 240 250
RHQRIHTGKK PYECKECGKA FSCSSYFSQH QRIHTGEKPY ECKECGKAFK
260 270 280 290 300
YCSNLNDHQR IHTGEKPYEC KVCGKAFTKS SQLFLHLRIH TGEKPYECKE
310 320 330 340 350
CGKAFTQHSR LIQHQRMHTG EKPYECKQCG KAFNSASTLT NHHRIHAGEK
360 370 380 390 400
LYECEECRKA FIQSSELIQH QRIHTDEKPY ECNECGKAFN KGSNLTRHQR
410 420 430
IHTGEKPYDC KECGKAFGSR SDLIRHEGIH TG
Length:432
Mass (Da):50,142
Last modified:November 8, 2005 - v1
Checksum:i123E60C5564D53AD
GO
Isoform 2 (identifier: Q3KNS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     185-186: ES → MN

Show »
Length:248
Mass (Da):28,678
Checksum:i2522DE8B627785F2
GO
Isoform 3 (identifier: Q3KNS6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTGKGLGEDT...SPEPLELDRM

Show »
Length:513
Mass (Da):58,565
Checksum:i732ABD95CC57DA62
GO

Sequence cautioni

The sequence CAD98083 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0337691 – 184Missing in isoform 2. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_0576061M → MTGKGLGEDTEDRWGAGALG PCGRSGLKGGGCVWEAEAGG SRGQEIETILANMETSLRSG QIPTLDSSEHNLSPEPLELD RM in isoform 3. 1
Alternative sequenceiVSP_033770185 – 186ES → MN in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538288 mRNA. Translation: CAD98083.1. Different initiation.
BC107131 mRNA. Translation: AAI07132.1.
BC107132 mRNA. Translation: AAI07133.1.
AK130969 mRNA. Translation: BAC85471.1.
AC008733 Genomic DNA. No translation available.
KC877740 Genomic DNA. No translation available.
CCDSiCCDS42557.1. [Q3KNS6-1]
CCDS59380.1. [Q3KNS6-3]
RefSeqiNP_001032309.2. NM_001037232.3. [Q3KNS6-1]
NP_001165450.1. NM_001171979.1. [Q3KNS6-3]
XP_005258933.1. XM_005258876.4. [Q3KNS6-1]
XP_011525235.1. XM_011526933.2. [Q3KNS6-1]
UniGeneiHs.720312.

Genome annotation databases

EnsembliENST00000391711; ENSP00000429266; ENSG00000185869. [Q3KNS6-1]
ENST00000520965; ENSP00000428679; ENSG00000185869. [Q3KNS6-3]
GeneIDi374899.
KEGGihsa:374899.
UCSCiuc002ofa.3. human. [Q3KNS6-1]
uc021utr.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538288 mRNA. Translation: CAD98083.1. Different initiation.
BC107131 mRNA. Translation: AAI07132.1.
BC107132 mRNA. Translation: AAI07133.1.
AK130969 mRNA. Translation: BAC85471.1.
AC008733 Genomic DNA. No translation available.
KC877740 Genomic DNA. No translation available.
CCDSiCCDS42557.1. [Q3KNS6-1]
CCDS59380.1. [Q3KNS6-3]
RefSeqiNP_001032309.2. NM_001037232.3. [Q3KNS6-1]
NP_001165450.1. NM_001171979.1. [Q3KNS6-3]
XP_005258933.1. XM_005258876.4. [Q3KNS6-1]
XP_011525235.1. XM_011526933.2. [Q3KNS6-1]
UniGeneiHs.720312.

3D structure databases

ProteinModelPortaliQ3KNS6.
SMRiQ3KNS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131934. 8 interactors.
IntActiQ3KNS6. 5 interactors.
MINTiMINT-8417749.
STRINGi9606.ENSP00000429266.

PTM databases

iPTMnetiQ3KNS6.
PhosphoSitePlusiQ3KNS6.

Polymorphism and mutation databases

BioMutaiZNF829.
DMDMi121947691.

Proteomic databases

MaxQBiQ3KNS6.
PaxDbiQ3KNS6.
PeptideAtlasiQ3KNS6.
PRIDEiQ3KNS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391711; ENSP00000429266; ENSG00000185869. [Q3KNS6-1]
ENST00000520965; ENSP00000428679; ENSG00000185869. [Q3KNS6-3]
GeneIDi374899.
KEGGihsa:374899.
UCSCiuc002ofa.3. human. [Q3KNS6-1]
uc021utr.1. human.

Organism-specific databases

CTDi374899.
DisGeNETi374899.
GeneCardsiZNF829.
HGNCiHGNC:34032. ZNF829.
neXtProtiNX_Q3KNS6.
OpenTargetsiENSG00000185869.
PharmGKBiPA162410750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3KNS6.
KOiK09228.
OMAiMFRDVSI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3KNS6.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:G66-32607-MONOMER.

Miscellaneous databases

GenomeRNAii374899.
PROiQ3KNS6.

Gene expression databases

BgeeiENSG00000185869.
CleanExiHS_ZNF829.
GenevisibleiQ3KNS6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN829_HUMAN
AccessioniPrimary (citable) accession number: Q3KNS6
Secondary accession number(s): A0A075B6T0
, Q3KNS7, Q6ZNN0, Q7Z657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.