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Protein

Zinc finger protein 829

Gene

ZNF829

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 829
Gene namesi
Name:ZNF829
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000185869.13
HGNCiHGNC:34032 ZNF829
neXtProtiNX_Q3KNS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi374899
OpenTargetsiENSG00000185869
PharmGKBiPA162410750

Polymorphism and mutation databases

BioMutaiZNF829
DMDMi121947691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003358081 – 432Zinc finger protein 829Add BLAST432

Proteomic databases

MaxQBiQ3KNS6
PaxDbiQ3KNS6
PeptideAtlasiQ3KNS6
PRIDEiQ3KNS6
ProteomicsDBi61696
61697 [Q3KNS6-2]

PTM databases

iPTMnetiQ3KNS6
PhosphoSitePlusiQ3KNS6

Expressioni

Gene expression databases

BgeeiENSG00000185869
CleanExiHS_ZNF829
GenevisibleiQ3KNS6 HS

Organism-specific databases

HPAiHPA073073

Interactioni

Protein-protein interaction databases

BioGridi131934, 8 interactors
IntActiQ3KNS6, 5 interactors
MINTiQ3KNS6
STRINGi9606.ENSP00000429266

Structurei

3D structure databases

ProteinModelPortaliQ3KNS6
SMRiQ3KNS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 106KRABPROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 20Poly-Glu4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ3KNS6
KOiK09228
OMAiCSNLNDH
OrthoDBiEOG091G02KC
PhylomeDBiQ3KNS6
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3KNS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHSPLISIP HVWCHPEEEE RMHDELLQAV SKGPVMFRDV SIDFSQEEWE
60 70 80 90 100
CLDADQMNLY KEVMLENFSN LVSVGLSNSK PAVISLLEQG KEPWMVDREL
110 120 130 140 150
TRGLCSDLES MCETKILSLK KRHFSQVIIT REDMSTFIQP TFLIPPQKTM
160 170 180 190 200
SEEKPWECKI CGKTFNQNSQ FIQHQRIHFG EKHYESKEYG KSFSRGSLVT
210 220 230 240 250
RHQRIHTGKK PYECKECGKA FSCSSYFSQH QRIHTGEKPY ECKECGKAFK
260 270 280 290 300
YCSNLNDHQR IHTGEKPYEC KVCGKAFTKS SQLFLHLRIH TGEKPYECKE
310 320 330 340 350
CGKAFTQHSR LIQHQRMHTG EKPYECKQCG KAFNSASTLT NHHRIHAGEK
360 370 380 390 400
LYECEECRKA FIQSSELIQH QRIHTDEKPY ECNECGKAFN KGSNLTRHQR
410 420 430
IHTGEKPYDC KECGKAFGSR SDLIRHEGIH TG
Length:432
Mass (Da):50,142
Last modified:November 8, 2005 - v1
Checksum:i123E60C5564D53AD
GO
Isoform 2 (identifier: Q3KNS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     185-186: ES → MN

Show »
Length:248
Mass (Da):28,678
Checksum:i2522DE8B627785F2
GO
Isoform 3 (identifier: Q3KNS6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTGKGLGEDT...SPEPLELDRM

Show »
Length:513
Mass (Da):58,565
Checksum:i732ABD95CC57DA62
GO

Sequence cautioni

The sequence CAD98083 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0337691 – 184Missing in isoform 2. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_0576061M → MTGKGLGEDTEDRWGAGALG PCGRSGLKGGGCVWEAEAGG SRGQEIETILANMETSLRSG QIPTLDSSEHNLSPEPLELD RM in isoform 3. 1
Alternative sequenceiVSP_033770185 – 186ES → MN in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538288 mRNA Translation: CAD98083.1 Different initiation.
BC107131 mRNA Translation: AAI07132.1
BC107132 mRNA Translation: AAI07133.1
AK130969 mRNA Translation: BAC85471.1
AC008733 Genomic DNA No translation available.
KC877740 Genomic DNA No translation available.
CCDSiCCDS42557.1 [Q3KNS6-1]
CCDS59380.1 [Q3KNS6-3]
RefSeqiNP_001032309.2, NM_001037232.3 [Q3KNS6-1]
NP_001165450.1, NM_001171979.1 [Q3KNS6-3]
XP_005258933.1, XM_005258876.4 [Q3KNS6-1]
XP_011525235.1, XM_011526933.2 [Q3KNS6-1]
UniGeneiHs.720312

Genome annotation databases

EnsembliENST00000391711; ENSP00000429266; ENSG00000185869 [Q3KNS6-1]
ENST00000520965; ENSP00000428679; ENSG00000185869 [Q3KNS6-3]
GeneIDi374899
KEGGihsa:374899
UCSCiuc002ofa.3 human [Q3KNS6-1]
uc021utr.1 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN829_HUMAN
AccessioniPrimary (citable) accession number: Q3KNS6
Secondary accession number(s): A0A075B6T0
, Q3KNS7, Q6ZNN0, Q7Z657
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 8, 2005
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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