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Protein

Mas-related G-protein coupled receptor member B2

Gene

Mrgprb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member B2
Gene namesi
Name:Mrgprb2
Synonyms:Mrgb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2441674. Mrgprb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 8928CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini111 – 1111ExtracellularSequence Analysis
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 15725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini179 – 19113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini213 – 23119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei232 – 25221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini253 – 26816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 33849CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Mas-related G-protein coupled receptor member B2PRO_0000304878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3KNA1.

PTM databases

PhosphoSiteiQ3KNA1.

Expressioni

Gene expression databases

BgeeiQ3KNA1.
CleanExiMM_MRGPRB2.
ExpressionAtlasiQ3KNA1. baseline.
GenevestigatoriQ3KNA1.

Structurei

3D structure databases

ProteinModelPortaliQ3KNA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGieuNOG03703.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ3KNA1.
KOiK08396.
OMAiYSIDINI.
OrthoDBiEOG7KM5V6.
PhylomeDBiQ3KNA1.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KNA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGDFLIKNL STSAWKTNIT VLNGSYYIDT SVCVTRNQAM ILLSIIISLV
60 70 80 90 100
GMGLNAIVLW FLGIRMHTNA FTVYILNLAM ADFLYLCSQF VICLLIAFYI
110 120 130 140 150
FYSIDINIPL VLYVVPIFAY LSGLSILSTI SIERCLSVIW PIWYRCKRPR
160 170 180 190 200
HTSAITCFVL WVMSLLLGLL EGKACGLLFN SFDSYWCETF DVITNIWSVV
210 220 230 240 250
FFGVLCGSSL TLLVRIFCGS QRIPMTRLYV TITLTVLVFL IFGLPFGIYW
260 270 280 290 300
ILYQWISNFY YVEICNFYLE ILFLSCVNSC MNPIIYFLVG SIRHRRFRRK
310 320 330
TLKLLLQRAM QDTPEEEQSG NKSSSEHPEE LETVQSCS
Length:338
Mass (Da):38,832
Last modified:September 11, 2007 - v2
Checksum:i1B0A091D67C868B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281I → F in BAC26422. (PubMed:16141072)Curated
Sequence conflicti263 – 2631E → K in AAI07391. (PubMed:15489334)Curated
Sequence conflicti263 – 2631E → K in AAI07392. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042200 Genomic DNA. Translation: AAK91796.1.
AK029369 mRNA. Translation: BAC26422.1.
BC107390 mRNA. Translation: AAI07391.1.
BC107391 mRNA. Translation: AAI07392.1.
CCDSiCCDS21303.1.
RefSeqiNP_780740.2. NM_175531.4.
UniGeneiMm.83689.

Genome annotation databases

EnsembliENSMUST00000052730; ENSMUSP00000061878; ENSMUSG00000050425.
GeneIDi243979.
KEGGimmu:243979.
UCSCiuc009hat.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042200 Genomic DNA. Translation: AAK91796.1.
AK029369 mRNA. Translation: BAC26422.1.
BC107390 mRNA. Translation: AAI07391.1.
BC107391 mRNA. Translation: AAI07392.1.
CCDSiCCDS21303.1.
RefSeqiNP_780740.2. NM_175531.4.
UniGeneiMm.83689.

3D structure databases

ProteinModelPortaliQ3KNA1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ3KNA1.

Proteomic databases

PRIDEiQ3KNA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052730; ENSMUSP00000061878; ENSMUSG00000050425.
GeneIDi243979.
KEGGimmu:243979.
UCSCiuc009hat.2. mouse.

Organism-specific databases

CTDi243979.
MGIiMGI:2441674. Mrgprb2.

Phylogenomic databases

eggNOGieuNOG03703.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ3KNA1.
KOiK08396.
OMAiYSIDINI.
OrthoDBiEOG7KM5V6.
PhylomeDBiQ3KNA1.
TreeFamiTF336336.

Miscellaneous databases

NextBioi386078.
PROiQ3KNA1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3KNA1.
CleanExiMM_MRGPRB2.
ExpressionAtlasiQ3KNA1. baseline.
GenevestigatoriQ3KNA1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
    Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
    Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMRGB2_MOUSE
AccessioniPrimary (citable) accession number: Q3KNA1
Secondary accession number(s): Q8CDY4, Q91ZC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: January 7, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.