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Q3KNA1

- MRGB2_MOUSE

UniProt

Q3KNA1 - MRGB2_MOUSE

Protein

Mas-related G-protein coupled receptor member B2

Gene

Mrgprb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mas-related G-protein coupled receptor member B2
    Gene namesi
    Name:Mrgprb2
    Synonyms:Mrgb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2441674. Mrgprb2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Mas-related G-protein coupled receptor member B2PRO_0000304878Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ3KNA1.

    PTM databases

    PhosphoSiteiQ3KNA1.

    Expressioni

    Gene expression databases

    BgeeiQ3KNA1.
    CleanExiMM_MRGPRB2.
    GenevestigatoriQ3KNA1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3KNA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 8928CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 1111ExtracellularSequence Analysis
    Topological domaini133 – 15725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 19113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 23119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini253 – 26816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 33849CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGieuNOG03703.
    HOGENOMiHOG000015412.
    HOVERGENiHBG003592.
    InParanoidiQ3KNA1.
    KOiK08396.
    OMAiYSIDINI.
    OrthoDBiEOG7KM5V6.
    PhylomeDBiQ3KNA1.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR02108. MRGPCRFAMILY.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3KNA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDFLIKNL STSAWKTNIT VLNGSYYIDT SVCVTRNQAM ILLSIIISLV    50
    GMGLNAIVLW FLGIRMHTNA FTVYILNLAM ADFLYLCSQF VICLLIAFYI 100
    FYSIDINIPL VLYVVPIFAY LSGLSILSTI SIERCLSVIW PIWYRCKRPR 150
    HTSAITCFVL WVMSLLLGLL EGKACGLLFN SFDSYWCETF DVITNIWSVV 200
    FFGVLCGSSL TLLVRIFCGS QRIPMTRLYV TITLTVLVFL IFGLPFGIYW 250
    ILYQWISNFY YVEICNFYLE ILFLSCVNSC MNPIIYFLVG SIRHRRFRRK 300
    TLKLLLQRAM QDTPEEEQSG NKSSSEHPEE LETVQSCS 338
    Length:338
    Mass (Da):38,832
    Last modified:September 11, 2007 - v2
    Checksum:i1B0A091D67C868B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281I → F in BAC26422. (PubMed:16141072)Curated
    Sequence conflicti263 – 2631E → K in AAI07391. (PubMed:15489334)Curated
    Sequence conflicti263 – 2631E → K in AAI07392. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY042200 Genomic DNA. Translation: AAK91796.1.
    AK029369 mRNA. Translation: BAC26422.1.
    BC107390 mRNA. Translation: AAI07391.1.
    BC107391 mRNA. Translation: AAI07392.1.
    CCDSiCCDS21303.1.
    RefSeqiNP_780740.2. NM_175531.4.
    UniGeneiMm.83689.

    Genome annotation databases

    EnsembliENSMUST00000052730; ENSMUSP00000061878; ENSMUSG00000050425.
    GeneIDi243979.
    KEGGimmu:243979.
    UCSCiuc009hat.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY042200 Genomic DNA. Translation: AAK91796.1 .
    AK029369 mRNA. Translation: BAC26422.1 .
    BC107390 mRNA. Translation: AAI07391.1 .
    BC107391 mRNA. Translation: AAI07392.1 .
    CCDSi CCDS21303.1.
    RefSeqi NP_780740.2. NM_175531.4.
    UniGenei Mm.83689.

    3D structure databases

    ProteinModelPortali Q3KNA1.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q3KNA1.

    Proteomic databases

    PRIDEi Q3KNA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052730 ; ENSMUSP00000061878 ; ENSMUSG00000050425 .
    GeneIDi 243979.
    KEGGi mmu:243979.
    UCSCi uc009hat.2. mouse.

    Organism-specific databases

    CTDi 243979.
    MGIi MGI:2441674. Mrgprb2.

    Phylogenomic databases

    eggNOGi euNOG03703.
    HOGENOMi HOG000015412.
    HOVERGENi HBG003592.
    InParanoidi Q3KNA1.
    KOi K08396.
    OMAi YSIDINI.
    OrthoDBi EOG7KM5V6.
    PhylomeDBi Q3KNA1.
    TreeFami TF336336.

    Miscellaneous databases

    NextBioi 386078.
    PROi Q3KNA1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3KNA1.
    CleanExi MM_MRGPRB2.
    Genevestigatori Q3KNA1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR02108. MRGPCRFAMILY.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
      Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
      Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMRGB2_MOUSE
    AccessioniPrimary (citable) accession number: Q3KNA1
    Secondary accession number(s): Q8CDY4, Q91ZC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3