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Q3KNA1

- MRGB2_MOUSE

UniProt

Q3KNA1 - MRGB2_MOUSE

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Protein

Mas-related G-protein coupled receptor member B2

Gene
Mrgprb2, Mrgb2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member B2
Gene namesi
Name:Mrgprb2
Synonyms:Mrgb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2441674. Mrgprb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Extracellular Reviewed predictionAdd
BLAST
Transmembranei41 – 6121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini62 – 8928Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini111 – 1111Extracellular Reviewed prediction
Transmembranei112 – 13221Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini133 – 15725Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini179 – 19113Extracellular Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini213 – 23119Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini253 – 26816Extracellular Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini290 – 33849Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Mas-related G-protein coupled receptor member B2PRO_0000304878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3KNA1.

PTM databases

PhosphoSiteiQ3KNA1.

Expressioni

Gene expression databases

BgeeiQ3KNA1.
CleanExiMM_MRGPRB2.
GenevestigatoriQ3KNA1.

Structurei

3D structure databases

ProteinModelPortaliQ3KNA1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGieuNOG03703.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ3KNA1.
KOiK08396.
OMAiYSIDINI.
OrthoDBiEOG7KM5V6.
PhylomeDBiQ3KNA1.
TreeFamiTF336336.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KNA1-1 [UniParc]FASTAAdd to Basket

« Hide

MSGDFLIKNL STSAWKTNIT VLNGSYYIDT SVCVTRNQAM ILLSIIISLV    50
GMGLNAIVLW FLGIRMHTNA FTVYILNLAM ADFLYLCSQF VICLLIAFYI 100
FYSIDINIPL VLYVVPIFAY LSGLSILSTI SIERCLSVIW PIWYRCKRPR 150
HTSAITCFVL WVMSLLLGLL EGKACGLLFN SFDSYWCETF DVITNIWSVV 200
FFGVLCGSSL TLLVRIFCGS QRIPMTRLYV TITLTVLVFL IFGLPFGIYW 250
ILYQWISNFY YVEICNFYLE ILFLSCVNSC MNPIIYFLVG SIRHRRFRRK 300
TLKLLLQRAM QDTPEEEQSG NKSSSEHPEE LETVQSCS 338
Length:338
Mass (Da):38,832
Last modified:September 11, 2007 - v2
Checksum:i1B0A091D67C868B9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281I → F in BAC26422. 1 Publication
Sequence conflicti263 – 2631E → K in AAI07391. 1 Publication
Sequence conflicti263 – 2631E → K in AAI07392. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY042200 Genomic DNA. Translation: AAK91796.1.
AK029369 mRNA. Translation: BAC26422.1.
BC107390 mRNA. Translation: AAI07391.1.
BC107391 mRNA. Translation: AAI07392.1.
CCDSiCCDS21303.1.
RefSeqiNP_780740.2. NM_175531.4.
UniGeneiMm.83689.

Genome annotation databases

EnsembliENSMUST00000052730; ENSMUSP00000061878; ENSMUSG00000050425.
GeneIDi243979.
KEGGimmu:243979.
UCSCiuc009hat.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY042200 Genomic DNA. Translation: AAK91796.1 .
AK029369 mRNA. Translation: BAC26422.1 .
BC107390 mRNA. Translation: AAI07391.1 .
BC107391 mRNA. Translation: AAI07392.1 .
CCDSi CCDS21303.1.
RefSeqi NP_780740.2. NM_175531.4.
UniGenei Mm.83689.

3D structure databases

ProteinModelPortali Q3KNA1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q3KNA1.

Proteomic databases

PRIDEi Q3KNA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052730 ; ENSMUSP00000061878 ; ENSMUSG00000050425 .
GeneIDi 243979.
KEGGi mmu:243979.
UCSCi uc009hat.2. mouse.

Organism-specific databases

CTDi 243979.
MGIi MGI:2441674. Mrgprb2.

Phylogenomic databases

eggNOGi euNOG03703.
HOGENOMi HOG000015412.
HOVERGENi HBG003592.
InParanoidi Q3KNA1.
KOi K08396.
OMAi YSIDINI.
OrthoDBi EOG7KM5V6.
PhylomeDBi Q3KNA1.
TreeFami TF336336.

Miscellaneous databases

NextBioi 386078.
PROi Q3KNA1.
SOURCEi Search...

Gene expression databases

Bgeei Q3KNA1.
CleanExi MM_MRGPRB2.
Genevestigatori Q3KNA1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view ]
PANTHERi PTHR11334. PTHR11334. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
    Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
    Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMRGB2_MOUSE
AccessioniPrimary (citable) accession number: Q3KNA1
Secondary accession number(s): Q8CDY4, Q91ZC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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