Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3KNA1 (MRGB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member B2
Gene names
Name:Mrgprb2
Synonyms:Mrgb2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Mas-related G-protein coupled receptor member B2
PRO_0000304878

Regions

Topological domain1 – 4040Extracellular Potential
Transmembrane41 – 6121Helical; Name=1; Potential
Topological domain62 – 8928Cytoplasmic Potential
Transmembrane90 – 11021Helical; Name=2; Potential
Topological domain1111Extracellular Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Topological domain133 – 15725Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 19113Extracellular Potential
Transmembrane192 – 21221Helical; Name=5; Potential
Topological domain213 – 23119Cytoplasmic Potential
Transmembrane232 – 25221Helical; Name=6; Potential
Topological domain253 – 26816Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 33849Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict281I → F in BAC26422. Ref.2
Sequence conflict2631E → K in AAI07391. Ref.3
Sequence conflict2631E → K in AAI07392. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q3KNA1 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: 1B0A091D67C868B9

FASTA33838,832
        10         20         30         40         50         60 
MSGDFLIKNL STSAWKTNIT VLNGSYYIDT SVCVTRNQAM ILLSIIISLV GMGLNAIVLW 

        70         80         90        100        110        120 
FLGIRMHTNA FTVYILNLAM ADFLYLCSQF VICLLIAFYI FYSIDINIPL VLYVVPIFAY 

       130        140        150        160        170        180 
LSGLSILSTI SIERCLSVIW PIWYRCKRPR HTSAITCFVL WVMSLLLGLL EGKACGLLFN 

       190        200        210        220        230        240 
SFDSYWCETF DVITNIWSVV FFGVLCGSSL TLLVRIFCGS QRIPMTRLYV TITLTVLVFL 

       250        260        270        280        290        300 
IFGLPFGIYW ILYQWISNFY YVEICNFYLE ILFLSCVNSC MNPIIYFLVG SIRHRRFRRK 

       310        320        330 
TLKLLLQRAM QDTPEEEQSG NKSSSEHPEE LETVQSCS 

« Hide

References

« Hide 'large scale' references
[1]"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY042200 Genomic DNA. Translation: AAK91796.1.
AK029369 mRNA. Translation: BAC26422.1.
BC107390 mRNA. Translation: AAI07391.1.
BC107391 mRNA. Translation: AAI07392.1.
CCDSCCDS21303.1.
RefSeqNP_780740.2. NM_175531.4.
UniGeneMm.83689.

3D structure databases

ProteinModelPortalQ3KNA1.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ3KNA1.

Proteomic databases

PRIDEQ3KNA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052730; ENSMUSP00000061878; ENSMUSG00000050425.
GeneID243979.
KEGGmmu:243979.
UCSCuc009hat.2. mouse.

Organism-specific databases

CTD243979.
MGIMGI:2441674. Mrgprb2.

Phylogenomic databases

eggNOGeuNOG03703.
HOGENOMHOG000015412.
HOVERGENHBG003592.
InParanoidQ3KNA1.
KOK08396.
OMAYSIDINI.
OrthoDBEOG7KM5V6.
PhylomeDBQ3KNA1.
TreeFamTF336336.

Gene expression databases

BgeeQ3KNA1.
CleanExMM_MRGPRB2.
GenevestigatorQ3KNA1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386078.
PROQ3KNA1.
SOURCESearch...

Entry information

Entry nameMRGB2_MOUSE
AccessionPrimary (citable) accession number: Q3KNA1
Secondary accession number(s): Q8CDY4, Q91ZC2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries