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Reviewed, UniProtKB/Swiss-Prot Q3KMV0 (DXR_CHLTA)

Last modified June 16, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
      Short name=DXP reductoisomerase
    EC=1.1.1.267
Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomerase
    2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name: dxr
Ordered Locus Names: CTA_0076
OrganismChlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

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Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity.

Pathway

Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via DXP pathway; isopentenyl-PP from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3793791-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
PRO_1000020245

Regions

Nucleotide binding7 – 3630NADP By similarity

Sites

Metal binding1471Divalent metal cation By similarity
Metal binding1491Divalent metal cation By similarity
Metal binding2181Divalent metal cation By similarity
Binding site1221Substrate By similarity
Binding site1491Substrate By similarity
Binding site1731Substrate By similarity
Binding site1961Substrate By similarity
Binding site2181Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3KMV0-1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 3F00933320E54E4C

FASTA37941,762
        10         20         30         40         50         60 
MKHLALIGST GSIGRQVLQV VRSIPDTFII ETLAAYGRNQ EALISQIREF NPRVVAVREE 

        70         80         90        100        110        120 
TTYKELRKLF PHIEILLGEE GLVSVATEPS VTMTIVASSG IDALPAVIAA IRQKKTIALA 

       130        140        150        160        170        180 
NKESLVAAGE LVTTLARENG VQILPIDSEH NALFQCLEGR DSSTIKKLLL TASGGPLRNK 

       190        200        210        220        230        240 
SKEELQKVSL QEVLRHPVWN MGPKITVDSS TLVNKGLEII EAFWLFGLEA VEIEAVIHPQ 

       250        260        270        280        290        300 
SLVHGMVEFC DGTILSVMNP PSMLFPIQHV LTFPERSPAI GPGFDFLSNR TLEFFPIDED 

       310        320        330        340        350        360 
RFPSVHLAKR VLLEKGSMGC FFNGANEALV HRFLAGEISW HQIVPKLQAL VDQHRVQSCL 

       370 
SLEEILSVDA EARARAQEC

« Hide

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References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000051 Genomic DNA. Translation: AAX50322.1.
RefSeqYP_327870.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3687563.
GenomeReviewsGene locus CTA_0076 in contig CP000051_GR.
KEGGcta:CTA_0076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ3KMV0.
OMAQ3KMV0. IHSMVEY.

Enzyme and pathway databases

BioCycCTRA315277-1:CTA_0076-MON.

Family and domain databases

HAMAPMF_00183.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
[Graphical view]
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameDXR_CHLTA
AccessionPrimary (citable) accession number: Q3KMV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents