Q3KMI0 (KDSB_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase

Gene names

Name:	kdsB
Ordered Locus Names:	CTA_0200

Organism

Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057
Pathway	Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057
Subcellular location	Cytoplasm Potential HAMAP MF_00057.
Sequence similarities	Belongs to the KdsB family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	3-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057		PRO_1000003355

Sequences

	Sequence		Length	Mass (Da)
	Q3KMI0 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 7F48F21C32950606	FASTA	254	28,011
	10 20 30 40 50 60 MFAFLTSKKV GILPSRWGSS RFPGKPLAKI LGKTLVQRSY ENALSSQSLD CVVVATDDQR 70 80 90 100 110 120 IFDHVVEFGG LCVMTSTSCA NGTERVEEVV SRHFPQAEIV VNIQGDEPCL SPTVIDGLVS 130 140 150 160 170 180 TLENNPAADM VTSVTETTDP EAILTDHKVK CVFDKNGKAL YFSRSAIPHN FKHPTPIYLH 190 200 210 220 230 240 IGVYAFRKAF LSEYVKIPPS SLSLAEDLEQ LRVLEIGRSI YVHVVQNATG PSVDYPEDIT 250 KVEQYLLCLS KASF

References

[1]

"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000051 Genomic DNA. Translation: AAX50442.1.
RefSeq	YP_327990.1. NC_007429.1.
3D structure databases
ProteinModelPortal	Q3KMI0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KMI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3687226.
GenomeReviews	Gene locus CTA_0200 in contig CP000051_GR.
KEGG	cta:CTA_0200.
PATRIC	32022266. VBIChlTra31516_0207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1212.
HOGENOM	HBG637773.
OMA	INVQADE.
PhylomeDB	Q3KMI0.
ProtClustDB	PRK05450.
Family and domain databases
HAMAP	MF_00057. CMP-KDO_synth. [Tree]
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
KO	K00979.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. KdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSB_CHLTA

Accession

Primary (citable) accession number: Q3KMI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program