Reviewed,
UniProtKB/Swiss-Prot Q3KMH9 (PYRG_CHLTA)
Last modified
June 16, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CTP synthase EC=6.3.4.2 Alternative name(s): UTP--ammonia ligase CTP synthetase | ||||
| Gene names |
| ||||
| Organism | Chlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315277 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia |
Protein attributes
| Sequence length | 539 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. |
| Catalytic activity | ATP + UTP + NH3 = ADP + phosphate + CTP. HAMAP MF_01227 |
| Enzyme regulation | Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. |
| Pathway | Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP MF_01227 |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the CTP synthase family. Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CTP synthase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 539 | 539 | CTP synthase HAMAP MF_01227 | PRO_0000266090 | |||||
Regions | |||||||||
| Domain | 294 – 532 | 239 | Glutamine amidotransferase type-1 | ||||||
| Region | 1 – 255 | 255 | Aminator domain HAMAP MF_01227 | ||||||
Sites | |||||||||
| Active site | 380 | 1 | Nucleophile By similarity | ||||||
| Active site | 505 | 1 | By similarity | ||||||
| Active site | 507 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000051 Genomic DNA. Translation: AAX50443.1. | |
| RefSeq | YP_327991.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3687227. |
| GenomeReviews | Gene locus CTA_0201 in contig CP000051_GR. |
| KEGG | cta:CTA_0201. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q3KMH9. |
| OMA | Q3KMH9. EFNNAYR. |
Enzyme and pathway databases | |
| BioCyc | CTRA315277-1:CTA_0201-MON. |
Family and domain databases | |
| HAMAP | MF_01227. [Tree] |
| InterPro | IPR004468. CTP_synthase. IPR017456. CTP_synthase_N. IPR017926. GATASE_1. IPR000991. GATase_class1_C. [Graphical view] |
| PANTHER | PTHR11550. PyrG_synth. 1 hit. |
| Pfam | PF06418. CTP_synth_N. 1 hit. PF00117. GATase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00337. PyrG. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRG_CHLTA | ||||||||
| Accession | Primary (citable) accession number: Q3KMH9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


