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Q3KMH9 (PYRG_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTP synthase

EC=6.3.4.2
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene names
Name:pyrG
Ordered Locus Names:CTA_0201
OrganismChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP MF_01227

Catalytic activity

ATP + UTP + NH3 = ADP + phosphate + CTP. HAMAP MF_01227

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP MF_01227

Subunit structure

Homotetramer By similarity. HAMAP MF_01227

Sequence similarities

Belongs to the CTP synthase family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539CTP synthase HAMAP MF_01227
PRO_0000266090

Regions

Domain294 – 532239Glutamine amidotransferase type-1
Region1 – 255255Aminator domain HAMAP MF_01227

Sites

Active site3801Nucleophile By similarity
Active site5051 By similarity
Active site5071 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KMH9 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 413F7475BCDDD7CE

FASTA53960,204
        10         20         30         40         50         60 
MSFKSIFLTG GVVSSLGKGL TAASLALLLE RQDLKVAMLK LDPYLNVDPG TMNPYEHGEV 

        70         80         90        100        110        120 
YVTDDGVETD LDLGHYHRFS SVQLSKYSTA TSGQIYTKVL TKERNGEFLG STVQVIPHVT 

       130        140        150        160        170        180 
NEIINVIQSC ADHHKPDILI VEIGGTIGDI ESLPFLEAVR QFRCEHPQDC LSIHMTYVPY 

       190        200        210        220        230        240 
LRAAKEIKTK PTQHSVQNLR SIGISPDVIL CRSEAPLSTE VKRKISLFCN VPEHAVFNAI 

       250        260        270        280        290        300 
DLERSIYEMP LLLAKENISD FLLNKLGFSP KPLDLSDWQD LVEALCDKER QHVRIGLVGK 

       310        320        330        340        350        360 
YLEHEDAYKS VFESLFHASV PANCSLELVP IAPESEDLLE QLSQCDGCLI PGGFGTRSWE 

       370        380        390        400        410        420 
GKISAARYCR ERNIPCFGIC LGMQALVVEY ARNVLDKPLA NSMEINPETP DPVVCMMEGQ 

       430        440        450        460        470        480 
DSVVKGGTMR LGAYPCRIAP GSLASAAYKT DLVQERHRHR YEVNPSYIER LEEHGLKIAG 

       490        500        510        520        530 
VCPLGELCEI VEIPNHRWML GVQFHPEFLS KLAKPHPLFI EFIRAAKAYS LEKANHEHR 

« Hide

References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000051 Genomic DNA. Translation: AAX50443.1.
RefSeqYP_327991.1. NC_007429.1.

3D structure databases

HSSPHSSP built from PDB template 2C5M based on UniProtKB P17812.
ProteinModelPortalQ3KMH9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3KMH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3687227.
GenomeReviewsGene locus CTA_0201 in contig CP000051_GR.
KEGGcta:CTA_0201.
PATRIC32022268. VBIChlTra31516_0208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0504.
HOGENOMHBG597806.
OMACRAERNI.
PhylomeDBQ3KMH9.
ProtClustDBPRK05380.

Family and domain databases

HAMAPMF_01227. PyrG.
[Tree]
InterProIPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE_1.
[Graphical view]
KOK01937.
PANTHERPTHR11550. PyrG_synth. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRG_CHLTA
AccessionPrimary (citable) accession number: Q3KMH9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families