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Q3KMF2

- GSA_CHLTA

UniProt

Q3KMF2 - GSA_CHLTA

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCTRA315277:GI4C-230-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CTA_0230
OrganismiChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Taxonomic identifieri315277 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002532: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000243560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei258 – 2581N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315277.CTA_0230.

Structurei

3D structure databases

ProteinModelPortaliQ3KMF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiTHIRPAN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KMF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHLFSKACQ YFPGGVNSPV RACRAVNITP PIVARASKEV FVDSLDKTFI
60 70 80 90 100
DFCGSWGSLI HGHSHPKICA AIRQGLERGS SYGLTSEQEI LFAEEIFSYL
110 120 130 140 150
GLETNYKIRF MSTGSEATMT AVRLARGITG RPIIIKFLGC YHGHADTFLQ
160 170 180 190 200
EKPFSHTSLE TLDLAHPLTL SLPFNDFPLF QTVMNSLGHK VAGVIFEPVC
210 220 230 240 250
ANMGVILPVP GFIEGVIQTC QQTGSFSIMD EVVTGFRVAQ GGAAALYHVK
260 270 280 290 300
PDILVFGKIL GGGLPASAVV TPKDIMDHLA PEGKIFQAGT LSGNPLAMIA
310 320 330 340 350
GKVSVNLCRE QGFYTQLATI EQNFLSPIEH MIRTTGIPVT LVRYGSLFSF
360 370 380 390 400
FFNPNRPNNL ADAQLSDIEA FQKFYQSAFS KGVYLSPSPF EASFLSAAHS
410 420
MESLDYAQTA LIESLEQVFS LV
Length:422
Mass (Da):45,912
Last modified:November 8, 2005 - v1
Checksum:iF5E0FF0C1E243632
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000051 Genomic DNA. Translation: AAX50470.1.
RefSeqiYP_328018.1. NC_007429.1.

Genome annotation databases

EnsemblBacteriaiAAX50470; AAX50470; CTA_0230.
GeneIDi3688016.
KEGGicta:CTA_0230.
PATRICi32022328. VBIChlTra31516_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000051 Genomic DNA. Translation: AAX50470.1 .
RefSeqi YP_328018.1. NC_007429.1.

3D structure databases

ProteinModelPortali Q3KMF2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315277.CTA_0230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX50470 ; AAX50470 ; CTA_0230 .
GeneIDi 3688016.
KEGGi cta:CTA_0230.
PATRICi 32022328. VBIChlTra31516_0236.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi THIRPAN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci CTRA315277:GI4C-230-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
    Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
    Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAR-13 / ATCC VR-571B.

Entry informationi

Entry nameiGSA_CHLTA
AccessioniPrimary (citable) accession number: Q3KMF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3