Q3KMC3 (FABH_CHLTA) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 57.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 3 EC=2.3.1.180 Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase III Beta-ketoacyl-ACP synthase III Short name=KAS III | ||||
| Gene names |
| ||||
| Organism | Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315277 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia › ![]() |
Protein attributes
| Sequence length | 327 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP-Rule MF_01815 |
| Catalytic activity | Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP-Rule MF_01815 |
| Pathway | Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_01815 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Domain | The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP-Rule MF_01815 |
| Sequence similarities | Belongs to the FabH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism |
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological_process | fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: InterPro beta-ketoacyl-acyl-carrier-protein synthase III activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 327 | 327 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP-Rule MF_01815 | PRO_1000056341 | |||||
Regions | |||||||||
| Region | 254 – 258 | 5 | ACP-binding By similarity | ||||||
Sites | |||||||||
| Active site | 112 | 1 | By similarity | ||||||
| Active site | 253 | 1 | By similarity | ||||||
| Active site | 283 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAR-13 / ATCC VR-571B. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000051 Genomic DNA. Translation: AAX50499.1. |
| RefSeq | YP_328047.1. NC_007429.1. |
3D structure databases | |
| ProteinModelPortal | Q3KMC3. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 315277.CTA_0261. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAX50499; AAX50499; CTA_0261. |
| GeneID | 3687415. |
| KEGG | cta:CTA_0261. |
| PATRIC | 32022396. VBIChlTra31516_0268. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0332. |
| HOGENOM | HOG000246674. |
| KO | K00648. |
| OMA | IHHGAAF. |
| ProtClustDB | PRK09352. |
Enzyme and pathway databases | |
| BioCyc | CTRA315277:GI4C-299-MONOMER. |
| UniPathway | UPA00094. |
Family and domain databases | |
| Gene3D | 3.40.47.10. 2 hits. |
| HAMAP | MF_01815. FabH. |
| InterPro | IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view] |
| Pfam | PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view] |
| SUPFAM | SSF53901. Thiolase-like. 1 hit. |
| TIGRFAMs | TIGR00747. fabH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | FABH_CHLTA | ||||||||
| Accession | Primary (citable) accession number: Q3KMC3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
