Q3KM28 (DXS_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	CTA_0359

Organism

Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256398

Sequences

	Sequence		Length	Mass (Da)
	Q3KM28 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 0D45A1CBA81F66D1	FASTA	640	70,786
	10 20 30 40 50 60 MTYSLLPHIH SPQDLHALSL DKLPVLCDEI RNKIIESLSL TGGHLASNLG GVELTVALHY 70 80 90 100 110 120 VFSSPDDQFI FDVGHQSYVH KLLTGRNTEA FSNIRHDNGL SGFTTPQESN HDIFFSGHAG 130 140 150 160 170 180 NALSLALGLA KGSSNSSSHI LPILGDAAFS CGLTLEALNN IPADLSKFII VLNDNQMSIS 190 200 210 220 230 240 ENVGNIPQGI SHWMYPQKIS KLSQKIHSWI QNLPSFLHKK KTLSHKVDIA LKSLSHPLFE 250 260 270 280 290 300 QFGLHYVGPI DGHNVKKLVQ ALQMIKDQPQ PILFHVCTVK GNGLAEAERD PIRYHGVKAH 310 320 330 340 350 360 FQNTSLKKTS GNVELQTPIS FPQHAGNILC RLGKKYPQLQ VVTPAMSLGS CLEDFRKQFP 370 380 390 400 410 420 DRFTDVGIAE GHAVTFSAGI ARSGTPVCCS IYSTFLHRAM DNVFHDVCMQ ELPVIFAIDR 430 440 450 460 470 480 AGLAFHDGRS HHGIYDLGFL CSMPNMVICQ PRNALVLERL FFSSLLWKSP CAIRYPNIPA 490 500 510 520 530 540 NEKASNSFFP FSPILPGEAE ILCQGDDLLL IALGHMCNTA LTVKEHLLDY GISTTVVDPI 550 560 570 580 590 600 FIKPLDRKLL QSLLTHHSKV IILEEHSIHG GLGSEFLLFL NQHNIKADVL SLGVPDMFIP 610 620 630 640 HGNPETILNL IGLTSDHITQ RILSHFKFFT PIPIERFFKA

References

[1]

"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000051 Genomic DNA. Translation: AAX50594.1.
RefSeq	YP_328142.1. NC_007429.1.
3D structure databases
ProteinModelPortal	Q3KM28.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KM28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3687988.
GenomeReviews	Gene locus CTA_0359 in contig CP000051_GR.
KEGG	cta:CTA_0359.
PATRIC	32022598. VBIChlTra31516_0366.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	EAMNAHA.
PhylomeDB	Q3KM28.
ProtClustDB	PRK05444.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_CHLTA

Accession

Primary (citable) accession number: Q3KM28

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program