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Q3KLZ5 (DAPA_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:CTA_0393
OrganismChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Dihydrodipicolinate synthase HAMAP MF_00418
PRO_1000050176

Sites

Active site1571Schiff-base intermediate with substrate By similarity
Site1291Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KLZ5 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 8CB9A156EAFDCE40

FASTA28631,291
        10         20         30         40         50         60 
MSVLGACITP FKADLSIDFA ALESVVRSQE HAGNGIILFG STGEGLSLTY EEKLSILSFV 

        70         80         90        100        110        120 
STLNLNVPIF VGVTATSVQE TMSWIDFAQQ WPIDGFLVPT PLYTRPGLNG QKAWFDRILS 

       130        140        150        160        170        180 
VSRKPIILYN NPIRTGVSLY PEVVKSFVSH PLCIGVKDSG GSAQACELFA ESGLRVFCGD 

       190        200        210        220        230        240 
DNLWPDMRLS GASGVISVLA NVWPELARDY VAQGRPIEAW KKVCSWLNLS TNPLGIKALM 

       250        260        270        280 
AAQKMIECDA VRPPLSIRDL QRRDELADIL ACRATLQTEL LSVCRQ

« Hide

References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000051 Genomic DNA. Translation: AAX50627.1.
RefSeqYP_328175.1. NC_007429.1.

3D structure databases

ProteinModelPortalQ3KLZ5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3KLZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3687371.
GenomeReviewsGene locus CTA_0393 in contig CP000051_GR.
KEGGcta:CTA_0393.
PATRIC32022666. VBIChlTra31516_0399.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHBG358848.
OMAASAHIHP.
PhylomeDBQ3KLZ5.
ProtClustDBPRK03170.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_CHLTA
AccessionPrimary (citable) accession number: Q3KLZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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