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Q3KLX6 (G6PI_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CTA_0412
OrganismChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAX50646.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000230916

Sites

Active site3461Proton donor By similarity
Active site3771 By similarity
Active site4921 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KLX6 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 4245A7E42A2735C5

FASTA52457,649
        10         20         30         40         50         60 
MGKGFLDCES LVALQEMALH PIDLTASGCL SEERIQKNSL SAEGFTYSYA TERVDDRCLE 

        70         80         90        100        110        120 
ALQGLTEERE LIKQMECMQQ GAIMNRIEGF QSESRPVLHT ATRAWVRDQD LHEEAAAIAR 

       130        140        150        160        170        180 
HSKEEALRLA EFLYIARAKF STLVQMGIGG SELGPKAMYF AMQGSCPSDK RIFFVSNIDP 

       190        200        210        220        230        240 
DNAAEVLREI DLEQTLVVVV SKSGTTLEPA ANEELFRQAY QNKGLSIAKH FVAVTSQGSP 

       250        260        270        280        290        300 
MDDKSRYLEV FHLWDSIGGR FSATSMVGGV VLGFAFGYEA FIEFLQGAAA IDAHALTPKM 

       310        320        330        340        350        360 
RENLPLLSAM LGVWNRNLLG YPTTAVIPYS TGLKYFTAHL QQCGMESNGK SISREGKEIS 

       370        380        390        400        410        420 
FRTSPIIWGD VGTNCQHSFF QSLHQGTDIV PVEFIGFLHN QRGLDCVLSG SSSSQKLFAN 

       430        440        450        460        470        480 
LVAQSLALAQ GRDNANSNKR FKGNRPSSIL VAQQLSPRIA GSLLAFYEHK FAFQGFCWGI 

       490        500        510        520 
NSFDQEGVSL GKELATQIIG IMSGNAPVEF PEARGMLRLF NVLT 

« Hide

References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000051 Genomic DNA. Translation: AAX50646.1. Different initiation.
RefSeqYP_328194.1. NC_007429.1.

3D structure databases

ProteinModelPortalQ3KLX6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315277.CTA_0412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX50646; AAX50646; CTA_0412.
GeneID3688040.
KEGGcta:CTA_0412.
PATRIC32022706. VBIChlTra31516_0419.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMAISIYESN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycCTRA315277:GI4C-412-MONOMER.
UniPathwayUPA00109; UER00181.
UPA00138.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CHLTA
AccessionPrimary (citable) accession number: Q3KLX6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways