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Q3KLU2

- LPXB_CHLTA

UniProt

Q3KLU2 - LPXB_CHLTA

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCTRA315277:GI4C-446-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CTA_0446
OrganismiChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Taxonomic identifieri315277 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002532: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Lipid-A-disaccharide synthasePRO_0000255171Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315277.CTA_0446.

Structurei

3D structure databases

ProteinModelPortaliQ3KLU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownAdd
BLAST
Regioni225 – 607383Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KLU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPQKITLWL YPLGLFANLF FGTAFCVQWS LTRKKGYSVV PKIFWYLSGT
60 70 80 90 100
GAVFMICHGF IQSQYPIALL HSFNLIIYFR NLNIASLNPL PVSKIASLLV
110 120 130 140 150
SVATAITVSF AIGTRYLPHM TWMASPNILH LNLPEASLSW QLIGCIGLTI
160 170 180 190 200
FSLRFFIQWF YLEYKNQSAL PAPFWKASLL GGSICLLYFL RTGDLVNVLC
210 220 230 240 250
YGCGLFPSLA NLRIASREAF RKPFSNSCFI SAGEHSGDTL GGNLLKEMHA
260 270 280 290 300
KYPDIHCFGV GGPQMRAQNF HALFAMEKFQ VSGFWEVLLA LPKLWYRYQL
310 320 330 340 350
LYRNILKTNP RTVICIDFPD FHFLLIKKLR SRGYKGKIVH YVCPSIWAWR
360 370 380 390 400
PSRKTVLEKY LDLLLLILPF EQNLFKDSAL RTVYLGHPLS ETIKSFSPNL
410 420 430 440 450
NWKDQLHLPT DKPFIAAFPG SRRSDILRNL TIQVQAFQAS SLASTHHLLV
460 470 480 490 500
SSANPEYDHL ILEVLQQNRC LHSHIVPSQF RYELMRECDF ALAKCGTIVL
510 520 530 540 550
ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI
560 570 580 590 600
GGKKDFQYED VAAALNILKT SQAQEKQKDS CRDVYQAINE SASSMKECLS

LIFETAS
Length:607
Mass (Da):69,030
Last modified:November 8, 2005 - v1
Checksum:i8DF4430905BD6991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA. Translation: AAX50680.1.
RefSeqiYP_328228.1. NC_007429.1.

Genome annotation databases

EnsemblBacteriaiAAX50680; AAX50680; CTA_0446.
GeneIDi3687903.
KEGGicta:CTA_0446.
PATRICi32022780. VBIChlTra31516_0456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA. Translation: AAX50680.1 .
RefSeqi YP_328228.1. NC_007429.1.

3D structure databases

ProteinModelPortali Q3KLU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315277.CTA_0446.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX50680 ; AAX50680 ; CTA_0446 .
GeneIDi 3687903.
KEGGi cta:CTA_0446.
PATRICi 32022780. VBIChlTra31516_0456.

Phylogenomic databases

eggNOGi COG3952.
HOGENOMi HOG000034725.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CTRA315277:GI4C-446-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
    Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
    Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAR-13 / ATCC VR-571B.

Entry informationi

Entry nameiLPXB_CHLTA
AccessioniPrimary (citable) accession number: Q3KLU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3