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Q3KLU2

- LPXB_CHLTA

UniProt

Q3KLU2 - LPXB_CHLTA

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, CTA_0446
Organism
Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCTRA315277:GI4C-446-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CTA_0446
OrganismiChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Taxonomic identifieri315277 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002532: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255171Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315277.CTA_0446.

Structurei

3D structure databases

ProteinModelPortaliQ3KLU2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownUniRule annotationAdd
BLAST
Regioni225 – 607383Lipid-A-disaccharide synthaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KLU2-1 [UniParc]FASTAAdd to Basket

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MFPQKITLWL YPLGLFANLF FGTAFCVQWS LTRKKGYSVV PKIFWYLSGT    50
GAVFMICHGF IQSQYPIALL HSFNLIIYFR NLNIASLNPL PVSKIASLLV 100
SVATAITVSF AIGTRYLPHM TWMASPNILH LNLPEASLSW QLIGCIGLTI 150
FSLRFFIQWF YLEYKNQSAL PAPFWKASLL GGSICLLYFL RTGDLVNVLC 200
YGCGLFPSLA NLRIASREAF RKPFSNSCFI SAGEHSGDTL GGNLLKEMHA 250
KYPDIHCFGV GGPQMRAQNF HALFAMEKFQ VSGFWEVLLA LPKLWYRYQL 300
LYRNILKTNP RTVICIDFPD FHFLLIKKLR SRGYKGKIVH YVCPSIWAWR 350
PSRKTVLEKY LDLLLLILPF EQNLFKDSAL RTVYLGHPLS ETIKSFSPNL 400
NWKDQLHLPT DKPFIAAFPG SRRSDILRNL TIQVQAFQAS SLASTHHLLV 450
SSANPEYDHL ILEVLQQNRC LHSHIVPSQF RYELMRECDF ALAKCGTIVL 500
ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI 550
GGKKDFQYED VAAALNILKT SQAQEKQKDS CRDVYQAINE SASSMKECLS 600
LIFETAS 607
Length:607
Mass (Da):69,030
Last modified:November 8, 2005 - v1
Checksum:i8DF4430905BD6991
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000051 Genomic DNA. Translation: AAX50680.1.
RefSeqiYP_328228.1. NC_007429.1.

Genome annotation databases

EnsemblBacteriaiAAX50680; AAX50680; CTA_0446.
GeneIDi3687903.
KEGGicta:CTA_0446.
PATRICi32022780. VBIChlTra31516_0456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000051 Genomic DNA. Translation: AAX50680.1 .
RefSeqi YP_328228.1. NC_007429.1.

3D structure databases

ProteinModelPortali Q3KLU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315277.CTA_0446.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX50680 ; AAX50680 ; CTA_0446 .
GeneIDi 3687903.
KEGGi cta:CTA_0446.
PATRICi 32022780. VBIChlTra31516_0456.

Phylogenomic databases

eggNOGi COG3952.
HOGENOMi HOG000034725.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CTRA315277:GI4C-446-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
    Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
    Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAR-13 / ATCC VR-571B.

Entry informationi

Entry nameiLPXB_CHLTA
AccessioniPrimary (citable) accession number: Q3KLU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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