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Q3KLU2

- LPXB_CHLTA

UniProt

Q3KLU2 - LPXB_CHLTA

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCTRA315277:GI4C-446-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:CTA_0446
    OrganismiChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
    Taxonomic identifieri315277 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000002532: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 607607Lipid-A-disaccharide synthasePRO_0000255171Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315277.CTA_0446.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3KLU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 224224UnknownAdd
    BLAST
    Regioni225 – 607383Lipid-A-disaccharide synthaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG3952.
    HOGENOMiHOG000034725.
    KOiK00748.
    OMAiKIIHYVC.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view]
    PfamiPF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view]
    ProDomiPD339292. LAB_N. 2 hits.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3KLU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPQKITLWL YPLGLFANLF FGTAFCVQWS LTRKKGYSVV PKIFWYLSGT    50
    GAVFMICHGF IQSQYPIALL HSFNLIIYFR NLNIASLNPL PVSKIASLLV 100
    SVATAITVSF AIGTRYLPHM TWMASPNILH LNLPEASLSW QLIGCIGLTI 150
    FSLRFFIQWF YLEYKNQSAL PAPFWKASLL GGSICLLYFL RTGDLVNVLC 200
    YGCGLFPSLA NLRIASREAF RKPFSNSCFI SAGEHSGDTL GGNLLKEMHA 250
    KYPDIHCFGV GGPQMRAQNF HALFAMEKFQ VSGFWEVLLA LPKLWYRYQL 300
    LYRNILKTNP RTVICIDFPD FHFLLIKKLR SRGYKGKIVH YVCPSIWAWR 350
    PSRKTVLEKY LDLLLLILPF EQNLFKDSAL RTVYLGHPLS ETIKSFSPNL 400
    NWKDQLHLPT DKPFIAAFPG SRRSDILRNL TIQVQAFQAS SLASTHHLLV 450
    SSANPEYDHL ILEVLQQNRC LHSHIVPSQF RYELMRECDF ALAKCGTIVL 500
    ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI 550
    GGKKDFQYED VAAALNILKT SQAQEKQKDS CRDVYQAINE SASSMKECLS 600
    LIFETAS 607
    Length:607
    Mass (Da):69,030
    Last modified:November 8, 2005 - v1
    Checksum:i8DF4430905BD6991
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000051 Genomic DNA. Translation: AAX50680.1.
    RefSeqiYP_328228.1. NC_007429.1.

    Genome annotation databases

    EnsemblBacteriaiAAX50680; AAX50680; CTA_0446.
    GeneIDi3687903.
    KEGGicta:CTA_0446.
    PATRICi32022780. VBIChlTra31516_0456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000051 Genomic DNA. Translation: AAX50680.1 .
    RefSeqi YP_328228.1. NC_007429.1.

    3D structure databases

    ProteinModelPortali Q3KLU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315277.CTA_0446.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX50680 ; AAX50680 ; CTA_0446 .
    GeneIDi 3687903.
    KEGGi cta:CTA_0446.
    PATRICi 32022780. VBIChlTra31516_0456.

    Phylogenomic databases

    eggNOGi COG3952.
    HOGENOMi HOG000034725.
    KOi K00748.
    OMAi KIIHYVC.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CTRA315277:GI4C-446-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view ]
    Pfami PF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view ]
    ProDomi PD339292. LAB_N. 2 hits.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
      Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
      Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAR-13 / ATCC VR-571B.

    Entry informationi

    Entry nameiLPXB_CHLTA
    AccessioniPrimary (citable) accession number: Q3KLU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3