Q3KLU2 (LPXB_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	CTA_0446

Organism

Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia › Chlamydia trachomatis

Protein attributes

Sequence length	607 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	In the C-terminal section; belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 607	607	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255171
Regions
	Region	1 – 224	224	Unknown HAMAP-Rule MF_00392
	Region	225 – 607	383	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

	Sequence		Length	Mass (Da)
	Q3KLU2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 8DF4430905BD6991	FASTA	607	69,030
	10 20 30 40 50 60 MFPQKITLWL YPLGLFANLF FGTAFCVQWS LTRKKGYSVV PKIFWYLSGT GAVFMICHGF 70 80 90 100 110 120 IQSQYPIALL HSFNLIIYFR NLNIASLNPL PVSKIASLLV SVATAITVSF AIGTRYLPHM 130 140 150 160 170 180 TWMASPNILH LNLPEASLSW QLIGCIGLTI FSLRFFIQWF YLEYKNQSAL PAPFWKASLL 190 200 210 220 230 240 GGSICLLYFL RTGDLVNVLC YGCGLFPSLA NLRIASREAF RKPFSNSCFI SAGEHSGDTL 250 260 270 280 290 300 GGNLLKEMHA KYPDIHCFGV GGPQMRAQNF HALFAMEKFQ VSGFWEVLLA LPKLWYRYQL 310 320 330 340 350 360 LYRNILKTNP RTVICIDFPD FHFLLIKKLR SRGYKGKIVH YVCPSIWAWR PSRKTVLEKY 370 380 390 400 410 420 LDLLLLILPF EQNLFKDSAL RTVYLGHPLS ETIKSFSPNL NWKDQLHLPT DKPFIAAFPG 430 440 450 460 470 480 SRRSDILRNL TIQVQAFQAS SLASTHHLLV SSANPEYDHL ILEVLQQNRC LHSHIVPSQF 490 500 510 520 530 540 RYELMRECDF ALAKCGTIVL ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII 550 560 570 580 590 600 LGRTIFPEFI GGKKDFQYED VAAALNILKT SQAQEKQKDS CRDVYQAINE SASSMKECLS LIFETAS

References

[1]

"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000051 Genomic DNA. Translation: AAX50680.1.
RefSeq	YP_328228.1. NC_007429.1.
3D structure databases
ProteinModelPortal	Q3KLU2.
ModBase	Search...
Protein-protein interaction databases
STRING	315277.CTA_0446.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX50680; AAX50680; CTA_0446.
GeneID	3687903.
KEGG	cta:CTA_0446.
PATRIC	32022780. VBIChlTra31516_0456.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3952.
HOGENOM	HOG000034725.
KO	K00748.
OMA	IPRILGI.
ProtClustDB	PRK01021.
Enzyme and pathway databases
BioCyc	CTRA315277:GI4C-480-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB. Fused.
InterPro	IPR003835. Glyco_trans_19. IPR011499. Lipid_A_biosynth. [Graphical view]
Pfam	PF07578. LAB_N. 2 hits. PF02684. LpxB. 1 hit. [Graphical view]
ProDom	PD339292. LAB_N. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_CHLTA

Accession

Primary (citable) accession number: Q3KLU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program