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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes DL-2,6-diaminopimelate from LL-2,6-diaminopimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Diaminopimelate epimerase (dapF)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes DL-2,6-diaminopimelate from LL-2,6-diaminopimelate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateUniRule annotation1
Binding sitei63SubstrateUniRule annotation1
Active sitei72Proton donorUniRule annotation1
Sitei147Could be important to modulate the pK values of the two catalytic cysteine residuesUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Sitei197Could be important to modulate the pK values of the two catalytic cysteine residuesUniRule annotation1
Active sitei207Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciCTRA315277:G1G4F-471-MONOMER
UniPathwayiUPA00034; UER00025

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Alternative name(s):
PLP-independent amino acid racemaseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:CTA_0470
OrganismiChlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)
Taxonomic identifieri315277 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000118671 – 275Diaminopimelate epimeraseAdd BLAST275

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ3KLS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 74Substrate bindingUniRule annotation2
Regioni197 – 198Substrate bindingUniRule annotation2
Regioni208 – 209Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220466
KOiK01778
OMAiSMCGNGG

Family and domain databases

HAMAPiMF_00197 DAP_epimerase, 1 hit
InterProiView protein in InterPro
IPR018510 DAP_epimerase_AS
IPR001653 DAP_epimerase_DapF
PANTHERiPTHR31689 PTHR31689, 1 hit
PfamiView protein in Pfam
PF01678 DAP_epimerase, 2 hits
TIGRFAMsiTIGR00652 DapF, 1 hit
PROSITEiView protein in PROSITE
PS01326 DAP_EPIMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3KLS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSSLLTTC RYLLYSGAGN SFILGESMPS LEDVLFLCQE EMVDGFLCVE
60 70 80 90 100
SSEIADAKLT VFNSDGSIAS MCGNGLRCAM AHVAQCFGLE DVSIETERGV
110 120 130 140 150
YQGKFFSMNR VLVDMTLPDW KKAERKLTHV LPGMPEQVFF IDAGVPHVVV
160 170 180 190 200
FVSDLSKVPV QEWGSFLRYH EDFAPEGVNV DFVQRKKDDL LLVYTYERGC
210 220 230 240 250
ERETLSCGTG MLASALVAAD IFSLGQDFSI AVCSRSRNLI KIFSEKGKVF
260 270
LEGPVSLLNR SENFGWLEPK SRRFG
Length:275
Mass (Da):30,546
Last modified:November 8, 2005 - v1
Checksum:i38883BBB99436F45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA Translation: AAX50702.1
RefSeqiWP_011324734.1, NC_007429.1

Genome annotation databases

EnsemblBacteriaiAAX50702; AAX50702; CTA_0470
KEGGicta:CTA_0470

Similar proteinsi

Entry informationi

Entry nameiDAPF_CHLTA
AccessioniPrimary (citable) accession number: Q3KLS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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