ID   HEMH_CHLTA              Reviewed;         314 AA.
AC   Q3KLL2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Ferrochelatase;
DE            EC=4.99.1.1;
DE   AltName: Full=Protoheme ferro-lyase;
DE   AltName: Full=Heme synthetase;
GN   Name=hemH; OrderedLocusNames=CTA_0532;
OS   Chlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia.
OX   NCBI_TaxID=315277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177312; DOI=10.1128/IAI.73.10.6407-6418.2005;
RA   Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.;
RT   "Comparative genomic analysis of Chlamydia trachomatis oculotropic and
RT   genitotropic strains.";
RL   Infect. Immun. 73:6407-6418(2005).
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC   -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC   -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC       from protoporphyrin-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR   EMBL; CP000051; AAX50760.1; -; Genomic_DNA.
DR   RefSeq; YP_328308.1; -.
DR   GeneID; 3687264; -.
DR   GenomeReviews; CP000051_GR; CTA_0532.
DR   KEGG; cta:CTA_0532; -.
DR   HOGENOM; Q3KLL2; -.
DR   OMA; Q3KLL2; NERCSTQ.
DR   BioCyc; CTRA315277-1:CTA_0532-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00323; -; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   PANTHER; PTHR11108; Ferrochelatase; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   ProDom; PD002792; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase;
KW   Metal-binding; Porphyrin biosynthesis.
FT   CHAIN         1    314       Ferrochelatase.
FT                                /FTId=PRO_1000019292.
FT   METAL       184    184       Iron (By similarity).
FT   METAL       259    259       Iron (By similarity).
SQ   SEQUENCE   314 AA;  35516 MW;  66217017A4DB2D42 CRC64;
     MVTYLLANFG GPRTSQEIVS FLQALLTDRD VTGGMIPSML HRPLFSYIAK RRAPHVARQY
     AYLGGGSPIF QDTERLAQNL SQELQASVIP FHRYLPETHR ETLQALQESQ GSIVGIPLFP
     HYTFAVTGSI IRFFLQHLPE KPISWITQFG VHPEFVSCMQ QHIRDCLAAQ QIAVEDCYFL
     FSVHGLPQRH IRLGDPYAQQ CQASFEALRG ELEGKIAFQS KFGIGKWLDP STQEVCQSLR
     TKKRHIVIVP FGFVSDHIET LHEIDHLYVP ILLQKGYRVV RIPAINASSR WVSSLAAIVR
     SSPQETSLEP LLMP
//