Reviewed, UniProtKB/Swiss-Prot Q3KLL2 (HEMH_CHLTA)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	CTA_0532

Organism

Chlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Ferrochelatase HAMAP MF_00323		PRO_1000019292
Sites
	Metal binding	184	1	Iron By similarity
	Metal binding	259	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3KLL2-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 66217017A4DB2D42	FASTA	314	35,516
	10 20 30 40 50 60 MVTYLLANFG GPRTSQEIVS FLQALLTDRD VTGGMIPSML HRPLFSYIAK RRAPHVARQY 70 80 90 100 110 120 AYLGGGSPIF QDTERLAQNL SQELQASVIP FHRYLPETHR ETLQALQESQ GSIVGIPLFP 130 140 150 160 170 180 HYTFAVTGSI IRFFLQHLPE KPISWITQFG VHPEFVSCMQ QHIRDCLAAQ QIAVEDCYFL 190 200 210 220 230 240 FSVHGLPQRH IRLGDPYAQQ CQASFEALRG ELEGKIAFQS KFGIGKWLDP STQEVCQSLR 250 260 270 280 290 300 TKKRHIVIVP FGFVSDHIET LHEIDHLYVP ILLQKGYRVV RIPAINASSR WVSSLAAIVR 310 SSPQETSLEP LLMP

References

[1]	"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000051 Genomic DNA. Translation: AAX50760.1.
RefSeq	YP_328308.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3687264.
GenomeReviews	Gene locus CTA_0532 in contig CP000051_GR.
KEGG	cta:CTA_0532.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3KLL2.
OMA	Q3KLL2. NERCSTQ.
Enzyme and pathway databases
BioCyc	CTRA315277-1:CTA_0532-MON.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_CHLTA

Accession

Primary (citable) accession number: Q3KLL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)