Q3KLG4 (LPXC_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	CTA_0582

Organism

Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the LpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388		PRO_0000253657

Sequences

	Sequence		Length	Mass (Da)
	Q3KLG4 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 5CB546469182E64C	FASTA	286	31,279
	10 20 30 40 50 60 MLGRAQRTLK RKVCYSGVGV HFGKAAMLTL EPAEENTGVV FSHHAASEQY IPARLANVCG 70 80 90 100 110 120 TGRSTTLSLD GSVISTVEHL LASLYSFGVD NVRIYCSEDE IPIGDGSAQV FMDLIDQAGI 130 140 150 160 170 180 QEQEQTVQIA RLAHPVYYQY QDTILAAFPS DEFKISYTLH YSHNSTIGTQ YRSLVISEES 190 200 210 220 230 240 FRKEIAPCRT FALYSELCFL MEKGLIGGGC VGNAVLFKDD GVISLGKLRF PDEPVRHKIL 250 260 270 280 DLIGDLSLVG TPFLAHVIAV GSGHSSNIAL GNRILEALQH EQELVK

References

[1]

"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000051 Genomic DNA. Translation: AAX50808.1.
RefSeq	YP_328356.1. NC_007429.1.
3D structure databases
ProteinModelPortal	Q3KLG4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KLG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3687623.
GenomeReviews	Gene locus CTA_0582 in contig CP000051_GR.
KEGG	cta:CTA_0582.
PATRIC	32023074. VBIChlTra31516_0596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	Q3KLG4.
ProtClustDB	PRK13186.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_CHLTA

Accession

Primary (citable) accession number: Q3KLG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program