Reviewed, UniProtKB/Swiss-Prot Q3KL90 (NTPA_CHLTA)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CTA_0658

Organism

Chlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Nucleoside-triphosphatase		PRO_1000068417

Sequences

	Sequence		Length	Mass (Da)
	Q3KL90-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 63C1B9D2F02758F5	FASTA	209	23,315
	10 20 30 40 50 60 MKILIASSHG YKVRETKVFL KKLGEFDIFS LVDYPSYHPP KETGETPEEN AIQKGLFAAQ 70 80 90 100 110 120 TFRCWTIADD SMLIIPALGG LPGKLSASFA GEQANDKDHR KKLLENMRLL ENTIDRSAYF 130 140 150 160 170 180 ECCVALISPF GKIFKAHASC EGTIAFEERG SSGFGYDPLF VKHDYKQTYA ELPEAIKNQV 190 200 SHRAKALVKL QPYVETVLAN HLLAGKESL

References

[1]	"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000051 Genomic DNA. Translation: AAX50882.1.
RefSeq	YP_328430.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3687502.
GenomeReviews	Gene locus CTA_0658 in contig CP000051_GR.
KEGG	cta:CTA_0658.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3KL90.
Enzyme and pathway databases
BioCyc	CTRA315277-1:CTA_0658-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_CHLTA

Accession

Primary (citable) accession number: Q3KL90

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 8, 2005
Last modified:	July 22, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)