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Q3KL90 (NTPA_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:CTA_0658
OrganismChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
PRO_1000068417

Regions

Region7 – 126Substrate binding By similarity
Region70 – 712Substrate binding By similarity

Sites

Metal binding701Magnesium or manganese By similarity
Binding site1571Substrate By similarity
Binding site1771Substrate By similarity
Binding site1831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KL90 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 63C1B9D2F02758F5

FASTA20923,315
        10         20         30         40         50         60 
MKILIASSHG YKVRETKVFL KKLGEFDIFS LVDYPSYHPP KETGETPEEN AIQKGLFAAQ 

        70         80         90        100        110        120 
TFRCWTIADD SMLIIPALGG LPGKLSASFA GEQANDKDHR KKLLENMRLL ENTIDRSAYF 

       130        140        150        160        170        180 
ECCVALISPF GKIFKAHASC EGTIAFEERG SSGFGYDPLF VKHDYKQTYA ELPEAIKNQV 

       190        200 
SHRAKALVKL QPYVETVLAN HLLAGKESL 

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References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000051 Genomic DNA. Translation: AAX50882.1.
RefSeqYP_328430.1. NC_007429.1.

3D structure databases

HSSPHSSP built from PDB template 2CAR based on UniProtKB Q9BY32.
ProteinModelPortalQ3KL90.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3KL90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3687502.
GenomeReviewsGene locus CTA_0658 in contig CP000051_GR.
KEGGcta:CTA_0658.
PATRIC32023232. VBIChlTra31516_0673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHBG697237.
OMAGEAHNDA.
PhylomeDBQ3KL90.
ProtClustDBPRK00120.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTPA_CHLTA
AccessionPrimary (citable) accession number: Q3KL90
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families