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Reviewed, UniProtKB/Swiss-Prot Q3KKU6 (DCUP_CHLTA)

Last modified June 16, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: CTA_0813
OrganismChlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

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Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023897

Regions

Region24 – 285Substrate binding By similarity

Sites

Binding site731Substrate By similarity
Binding site1421Substrate By similarity
Binding site1971Substrate By similarity
Binding site3121Substrate By similarity
Site731Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3KKU6-1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: B982F3661DD00859

FASTA33637,703
        10         20         30         40         50         60 
MPMTGFYETI SPRDQQRPPI WFLRQVGRYI PQYQELKRNR SLKDFFLDTE SIVEATLLGP 

        70         80         90        100        110        120 
SLLGVDAAIV FADILSILEG FSVDYRFAPG PEVSYSPHEP LIFTKDPQET FSFLLEAIQQ 

       130        140        150        160        170        180 
LTKRLTVPLI AFAASPFTLA SYLIEGGASR DYPKTIAFLY QYPDRFKALL DEITLGTATY 

       190        200        210        220        230        240 
LQMQVQAGAA AIQLFESSSL RLPPHLFAKY VVAPNTKLIR QIKQTGNPPI SLFCRCFYQE 

       250        260        270        280        290        300 
FLSLYAIGAD TLHPDYHVEL PEVYRQIHSP GSIQGNFDPA LLLLPQDALI AHLEAYLAPL 

       310        320        330 
KQQSHYIFNL GHGILPQTPI ENVQAVVSCL TSISTS

« Hide

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References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000051 Genomic DNA. Translation: AAX51026.1.
RefSeqYP_328574.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3687539.
GenomeReviewsGene locus CTA_0813 in contig CP000051_GR.
KEGGcta:CTA_0813.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ3KKU6.
OMAQ3KKU6. VFTKGGG.

Enzyme and pathway databases

BioCycCTRA315277-1:CTA_0813-MON.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_CHLTA
AccessionPrimary (citable) accession number: Q3KKU6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents