Q3KKS0 (IPYR_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase
EC=3.6.1.1

Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name=PPase

Gene names

Name:	ppa
Ordered Locus Names:	CTA_0842

Organism

Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]

Taxonomic identifier

315277 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00209.
Sequence similarities	Belongs to the PPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inorganic diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Inorganic pyrophosphatase HAMAP MF_00209		PRO_1000021251
Sites
	Metal binding	92	1	Magnesium 1 By similarity
	Metal binding	97	1	Magnesium 1 By similarity
	Metal binding	97	1	Magnesium 2 By similarity
	Metal binding	130	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3KKS0 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 7694093E5ADF0275	FASTA	209	23,391
	10 20 30 40 50 60 MSKTPLSIAH PWHGPVLTRD DYESLCCYIE ITPADSVKFE LDKETGILKV DRPQKFSNFC 70 80 90 100 110 120 PCLYGLLPKT YCGDLSGEYS GQQSNRENIK GDGDPLDICV LTEKNITQGN ILLQARPIGG 130 140 150 160 170 180 IRILDSEEAD DKIIAVLEDD LVYGNIEDIS ECPGTVLDMI QHYFLTYKAT PESLIQAKPA 190 200 KIEIVGLYGK KEAQKVIRLA HEDYCNLFM

References

[1]

"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains." Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D. Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000051 Genomic DNA. Translation: AAX51052.1.
RefSeq	YP_328600.1. NC_007429.1.
3D structure databases
HSSP	HSSP built from PDB template 1TWL based on UniProtKB Q8U438.
ProteinModelPortal	Q3KKS0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3KKS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3687852.
GenomeReviews	Gene locus CTA_0842 in contig CP000051_GR.
KEGG	cta:CTA_0842.
PATRIC	32023628. VBIChlTra31516_0857.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0221.
HOGENOM	HBG529150.
OMA	KTGMLKL.
PhylomeDB	Q3KKS0.
ProtClustDB	PRK00642.
Family and domain databases
HAMAP	MF_00209. Inorganic_PPase. [Tree]
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
Gene3D	G3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
KO	K01507.
PANTHER	PTHR10286. Pyrophosphatase. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IPYR_CHLTA

Accession

Primary (citable) accession number: Q3KKS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program