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Q3KKL0

- TRMB_CHLTA

UniProt

Q3KKL0 - TRMB_CHLTA

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491S-adenosyl-L-methionineUniRule annotation
Binding sitei74 – 741S-adenosyl-L-methionineUniRule annotation
Binding sitei101 – 1011S-adenosyl-L-methionineUniRule annotation
Active sitei124 – 1241By similarity
Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
Binding sitei128 – 1281SubstrateUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCTRA315277:GI4C-906-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:CTA_0903
OrganismiChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Taxonomic identifieri315277 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002532: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219tRNA (guanine-N(7)-)-methyltransferasePRO_0000288134Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315277.CTA_0903.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000034940.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KKL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLPYFWEER SPQIANHVFY VPNYYSRYEE FVMPTWQELF ANNGPICCEL
60 70 80 90 100
CSGNGDWVVE QALKDASVNW IAVEKRFDRV RKIWSKMGNY RVNNLLIVCG
110 120 130 140 150
EAQTFFSHYV SDASFQKIVV NFPDPWPKFR HRKHRLFQDL FVQDMMRTLV
160 170 180 190 200
VGGQLTLATD DYNYLVNAIT VMLKYLSPGL KSPHYINVKD NYGGSWFENL
210
WRSKGQEIFC TEFIKRVGI
Length:219
Mass (Da):25,854
Last modified:May 29, 2007 - v2
Checksum:i6A605C3022819F6A
GO

Sequence cautioni

The sequence AAX51112.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA. Translation: AAX51112.1. Different initiation.
RefSeqiYP_328660.2. NC_007429.1.

Genome annotation databases

EnsemblBacteriaiAAX51112; AAX51112; CTA_0903.
GeneIDi3688067.
KEGGicta:CTA_0903.
PATRICi32023760. VBIChlTra31516_0922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA. Translation: AAX51112.1 . Different initiation.
RefSeqi YP_328660.2. NC_007429.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315277.CTA_0903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX51112 ; AAX51112 ; CTA_0903 .
GeneIDi 3688067.
KEGGi cta:CTA_0903.
PATRICi 32023760. VBIChlTra31516_0922.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000034940.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CTRA315277:GI4C-906-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
    Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
    Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAR-13 / ATCC VR-571B.

Entry informationi

Entry nameiTRMB_CHLTA
AccessioniPrimary (citable) accession number: Q3KKL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3