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Q3KKL0

- TRMB_CHLTA

UniProt

Q3KKL0 - TRMB_CHLTA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491S-adenosyl-L-methionineUniRule annotation
    Binding sitei74 – 741S-adenosyl-L-methionineUniRule annotation
    Binding sitei101 – 1011S-adenosyl-L-methionineUniRule annotation
    Active sitei124 – 1241By similarity
    Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
    Binding sitei128 – 1281SubstrateUniRule annotation
    Binding sitei160 – 1601SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCTRA315277:GI4C-906-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:CTA_0903
    OrganismiChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B)
    Taxonomic identifieri315277 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000002532: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219tRNA (guanine-N(7)-)-methyltransferasePRO_0000288134Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315277.CTA_0903.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000034940.
    KOiK03439.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3KKL0-1 [UniParc]FASTAAdd to Basket

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    MKLPYFWEER SPQIANHVFY VPNYYSRYEE FVMPTWQELF ANNGPICCEL    50
    CSGNGDWVVE QALKDASVNW IAVEKRFDRV RKIWSKMGNY RVNNLLIVCG 100
    EAQTFFSHYV SDASFQKIVV NFPDPWPKFR HRKHRLFQDL FVQDMMRTLV 150
    VGGQLTLATD DYNYLVNAIT VMLKYLSPGL KSPHYINVKD NYGGSWFENL 200
    WRSKGQEIFC TEFIKRVGI 219
    Length:219
    Mass (Da):25,854
    Last modified:May 29, 2007 - v2
    Checksum:i6A605C3022819F6A
    GO

    Sequence cautioni

    The sequence AAX51112.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000051 Genomic DNA. Translation: AAX51112.1. Different initiation.
    RefSeqiYP_328660.2. NC_007429.1.

    Genome annotation databases

    EnsemblBacteriaiAAX51112; AAX51112; CTA_0903.
    GeneIDi3688067.
    KEGGicta:CTA_0903.
    PATRICi32023760. VBIChlTra31516_0922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000051 Genomic DNA. Translation: AAX51112.1 . Different initiation.
    RefSeqi YP_328660.2. NC_007429.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315277.CTA_0903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX51112 ; AAX51112 ; CTA_0903 .
    GeneIDi 3688067.
    KEGGi cta:CTA_0903.
    PATRICi 32023760. VBIChlTra31516_0922.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000034940.
    KOi K03439.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CTRA315277:GI4C-906-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
      Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
      Infect. Immun. 73:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAR-13 / ATCC VR-571B.

    Entry informationi

    Entry nameiTRMB_CHLTA
    AccessioniPrimary (citable) accession number: Q3KKL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3