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Q3KKL0 (TRMB_CHLTA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase
EC=2.1.1.33
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trmB
Ordered Locus Names:CTA_0903
OrganismChlamydia trachomatis serovar A (strain HAR-13 / ATCC VR-571B) [Complete proteome] [HAMAP]
Taxonomic identifier315277 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP MF_01057

Catalytic activity

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA. HAMAP MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP MF_01057

Sequence similarities

Belongs to the methyltransferase superfamily. TrmB family.

Sequence caution

The sequence AAX51112.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219tRNA (guanine-N(7)-)-methyltransferase HAMAP MF_01057
PRO_0000288134

Sites

Binding site491S-adenosyl-L-methionine By similarity
Binding site741S-adenosyl-L-methionine By similarity
Binding site1011S-adenosyl-L-methionine By similarity
Binding site1241S-adenosyl-L-methionine By similarity
Binding site1281Substrate By similarity
Binding site1601Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
Q3KKL0 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 6A605C3022819F6A

FASTA21925,854
        10         20         30         40         50         60 
MKLPYFWEER SPQIANHVFY VPNYYSRYEE FVMPTWQELF ANNGPICCEL CSGNGDWVVE 

        70         80         90        100        110        120 
QALKDASVNW IAVEKRFDRV RKIWSKMGNY RVNNLLIVCG EAQTFFSHYV SDASFQKIVV 

       130        140        150        160        170        180 
NFPDPWPKFR HRKHRLFQDL FVQDMMRTLV VGGQLTLATD DYNYLVNAIT VMLKYLSPGL 

       190        200        210 
KSPHYINVKD NYGGSWFENL WRSKGQEIFC TEFIKRVGI

« Hide

References

[1]"Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
Infect. Immun. 73:6407-6418(2005) [PubMed: 16177312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAR-13 / ATCC VR-571B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000051 Genomic DNA. Translation: AAX51112.1. Different initiation.
RefSeqYP_328660.2. NC_007429.1.

3D structure databases

ProteinModelPortalQ3KKL0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3KKL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3688067.
GenomeReviewsGene locus CTA_0903 in contig CP000051_GR.
KEGGcta:CTA_0903.
PATRIC32023760. VBIChlTra31516_0922.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0220.
HOGENOMHBG413880.
PhylomeDBQ3KKL0.
ProtClustDBPRK00121.

Family and domain databases

HAMAPMF_01057. tRNA_methyltr_TrmB.
[Tree]
InterProIPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
KOK03439.
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_CHLTA
AccessionPrimary (citable) accession number: Q3KKL0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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