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Q3KKE0 (HEM6_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:Pfl01_0022
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_1000019489

Regions

Region49 – 5810Important for dimerization By similarity
Region109 – 1113Substrate binding By similarity
Region241 – 27636Important for dimerization By similarity
Region259 – 2646Substrate binding By similarity

Sites

Active site1071Proton donor By similarity
Binding site931Substrate By similarity
Site1761Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KKE0 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 564ECF3E8DD3C1A3

FASTA30434,646
        10         20         30         40         50         60 
MTTRTDAVKA YLLDLQDRIC AALETEDGGT RFVEDAWTRP AGGGGRTRVI ENGTVIEKGG 

        70         80         90        100        110        120 
VNFSHVFGSG LPPSASAHRP ELAGRGFEAL GVSLVIHPHN PHVPTSHANV RFFIAEKEGE 

       130        140        150        160        170        180 
EPVWWFGGGF DLTPYYGNEE DCIHWHRVAE KACAPFGPDV YPRYKAWCDT YFHIKHRHEP 

       190        200        210        220        230        240 
RGIGGLFFDD LNEWDFDTSF AFMRAIGDAY IDAYLPIVQR RKNDAFTARQ REFQEFRRGR 

       250        260        270        280        290        300 
YVEFNLVYDR GTLFGLQSGG RTESILMSLP PQVRWAYDWK AEPGSEEARL TEYFLQDRDW 


LAQA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000094 Genomic DNA. Translation: ABA71766.1.
RefSeqYP_345755.1. NC_007492.2.

3D structure databases

ProteinModelPortalQ3KKE0.
SMRQ3KKE0. Positions 1-301.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3KKE0.

2D gel databases

World-2DPAGE0008:Q3KKE0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3717641.
GenomeReviewsGene locus Pfl01_0022 in contig CP000094_GR.
KEGGpfo:Pfl01_0022.
PATRIC19882052. VBIPseFlu44242_0022.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
PhylomeDBQ3KKE0.
ProtClustDBPRK05330.

Enzyme and pathway databases

BioCycPFLU205922:PFL_0022-MONOMER.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_PSEPF
AccessionPrimary (citable) accession number: Q3KKE0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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