Q3KIW4 (PNCB_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	Pfl01_0548

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas fluorescens group › Pseudomonas fluorescens

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000025007

Sequences

	Sequence		Length	Mass (Da)
	Q3KIW4 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 3194946C703E7918	FASTA	407	46,872
	10 20 30 40 50 60 MSESVFADRI VQNLLDTDFY KLTMMQAVLH NYPNVEVEWE FRCRNSEDLR PYLAEIRFQV 70 80 90 100 110 120 ERLAELSLSA DQLSFLERIS FLKPDFLRFL GLFRFNLRYL HTGIENGELF IRLRGPWLHV 130 140 150 160 170 180 ILFEVPLLAI VSEVRNRYRY RETVLEQARE QLYRKFDWLT ANASAEELSQ LQVADFGTRR 190 200 210 220 230 240 RFSYRVQEEV VNVLKHDFPG RFVGTSNVHL SRELDMKPLG TMAHEWIMAH QQLGPRLIDS 250 260 270 280 290 300 QIAALDCWVR EYRGLLGIAL TDCITTDAFL GDFDLFFAKL FDGLRHDSGD PVLWGEKCIA 310 320 330 340 350 360 HYHKLGIDPM SKTLVFSDSL TLPKSLEIFR ALRGRINVSF GIGTNLTCDI PGVEPMSIVL 370 380 390 400 KMTACNGQPV AKISDEPGKT HCKDPNFVAY LRHVFQVPAV SSLSSKE

References

[1]

"Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens." Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R., Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M., Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J., Harris S., Challis G.L., Yaxley A.M., Harris D. , Seeger K., Murphy L., Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K., Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M., Parkhill J., Levy S.B., Rainey P.B., Thomson N.R. Genome Biol. 10:R51.1-R51.16(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pf0-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000094 Genomic DNA. Translation: ABA72292.1.
RefSeq	YP_346281.1. NC_007492.2.
3D structure databases
HSSP	HSSP built from PDB template 1VLP based on UniProtKB P39683.
ProteinModelPortal	Q3KIW4.
SMR	Q3KIW4. Positions 1-397.
ModBase	Search...
Protein-protein interaction databases
STRING	205922.Pfl01_0548.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABA72292; ABA72292; Pfl01_0548.
GeneID	3712943.
KEGG	pfo:Pfl01_0548.
PATRIC	19883145. VBIPseFlu44242_0557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	HTGIENG.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	PFLU205922:GJBD-558-MONOMER.
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_PSEPF

Accession

Primary (citable) accession number: Q3KIW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program