Reviewed, UniProtKB/Swiss-Prot Q3KHZ1 (HIS81_PSEPF)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	Pfl01_0872

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000230220
Amino acid modifications
	Modified residue	210	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3KHZ1-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 88FCD2975D58367C	FASTA	350	38,555
	10 20 30 40 50 60 MSKFWSPFVK DLVPYVPGEQ PKLTRLVKLN TNENPYGPSP KALAAMQAEL NDNLRLYPDP 70 80 90 100 110 120 NSDLLKNAVA KYYGVQNNQV FLGNGSDEVL AHIFHGLLQH DQPILFPDIS YSFYPVYCGL 130 140 150 160 170 180 YGITFDAVPL DAQFRINPAD YAKPNGGIIF PNPNAPTGCL LALEAVEQIL KGSPDSVVVV 190 200 210 220 230 240 DEAYIDFGGE TAISLVDRYP NLLVTQTLSK SRSLAGLRVG LAVGHPDLIE ALERIKNSFN 250 260 270 280 290 300 SYPIDRMANV GAAAAFEDRE YFDKTCALVI ESREWVVAQL QAKGFEVLPS AANFIFARHP 310 320 330 340 350 QHDAAGLAAK LREQGVIVRH FKQERIAQFL RISIGTPEQN QALIDGLGEL

References

[1]

"Complete sequence of Pseudomonas fluorescens PfO-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyripides N., Anderson I., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000094 Genomic DNA. Translation: ABA72615.1.
RefSeq	YP_346604.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3715605.
GenomeReviews	Gene locus Pfl01_0872 in contig CP000094_GR.
KEGG	pfo:Pfl01_0872.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3KHZ1.
OMA	Q3KHZ1. DEQFQIR.
Enzyme and pathway databases
BioCyc	PFLU205922:PFL_0872-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_PSEPF

Accession

Primary (citable) accession number: Q3KHZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 8, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)