ID   HGD_PSEPF               Reviewed;         431 AA.
AC   Q3KHV3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   26-MAY-2009, entry version 30.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=Pfl01_0910;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyripides N., Anderson I., Richardson P.;
RT   "Complete sequence of Pseudomonas fluorescens PfO-1.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000094; ABA72653.1; -; Genomic_DNA.
DR   RefSeq; YP_346642.1; -.
DR   GeneID; 3715813; -.
DR   GenomeReviews; CP000094_GR; Pfl01_0910.
DR   KEGG; pfo:Pfl01_0910; -.
DR   HOGENOM; Q3KHV3; -.
DR   OMA; Q3KHV3; HRNCMSE.
DR   BioCyc; PFLU205922:PFL_0910-MON; -.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    431       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_0000225792.
FT   METAL       329    329       Iron (By similarity).
FT   METAL       335    335       Iron (By similarity).
FT   METAL       365    365       Iron (By similarity).
SQ   SEQUENCE   431 AA;  47490 MW;  796796E8D13A483B CRC64;
     MNLDSALAYQ SGFGNEFSSE ALPGALPVGQ NSPQKAPYGL YTELFSGTAF TMTRSEARRT
     WMYRIQPSAN HPAFVKLERQ LAGGPLGEVT PNRLRWNPLD LPTEPTDFID GLVSMAANSG
     ADKPAGISIY HYGANRSMER VFFNADGELL LVPQLGRLRI ATELGVLDVA PLEIAVLPRG
     LKFRVELLDP QARGYVAENH GAPLRLPDLG PIGSNGLANP RDFLTPVAAY ENLQQPTTLV
     QKFLGQLWGT ELNHSPLNVV AWHGNNVPYK YDLRRFNTIG TVSFDHPDPS IFTVLTSPTS
     VHGLANLDFV IFPPRWMVAE NTFRPPWFHR NLMNEFMGLI QGEYDAKAEG FVPGGASLHS
     CMSAHGPDGE TCTKAINADL KPAKIDNTMA FMFETSQVLR PSRFALDCPQ LQSTYDACWA
     TLPATFDPTR R
//