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Q3KHV3

- HGD_PSEPF

UniProt

Q3KHV3 - HGD_PSEPF

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Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, Pfl01_0910
Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861Proton acceptor By similarity
Metal bindingi329 – 3291Iron By similarity
Metal bindingi335 – 3351Iron By similarity
Binding sitei344 – 3441homogentisate By similarity
Metal bindingi365 – 3651Iron By similarity
Binding sitei365 – 3651homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-928-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:Pfl01_0910
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_0000225792Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi205922.Pfl01_0910.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiTTETHKL.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KHV3-1 [UniParc]FASTAAdd to Basket

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MNLDSALAYQ SGFGNEFSSE ALPGALPVGQ NSPQKAPYGL YTELFSGTAF    50
TMTRSEARRT WMYRIQPSAN HPAFVKLERQ LAGGPLGEVT PNRLRWNPLD 100
LPTEPTDFID GLVSMAANSG ADKPAGISIY HYGANRSMER VFFNADGELL 150
LVPQLGRLRI ATELGVLDVA PLEIAVLPRG LKFRVELLDP QARGYVAENH 200
GAPLRLPDLG PIGSNGLANP RDFLTPVAAY ENLQQPTTLV QKFLGQLWGT 250
ELNHSPLNVV AWHGNNVPYK YDLRRFNTIG TVSFDHPDPS IFTVLTSPTS 300
VHGLANLDFV IFPPRWMVAE NTFRPPWFHR NLMNEFMGLI QGEYDAKAEG 350
FVPGGASLHS CMSAHGPDGE TCTKAINADL KPAKIDNTMA FMFETSQVLR 400
PSRFALDCPQ LQSTYDACWA TLPATFDPTR R 431
Length:431
Mass (Da):47,490
Last modified:November 8, 2005 - v1
Checksum:i796796E8D13A483B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA72653.1.
RefSeqiWP_011332514.1. NC_007492.2.
YP_346642.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA72653; ABA72653; Pfl01_0910.
GeneIDi3715813.
KEGGipfo:Pfl01_0910.
PATRICi19883897. VBIPseFlu44242_0925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA72653.1 .
RefSeqi WP_011332514.1. NC_007492.2.
YP_346642.1. NC_007492.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_0910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA72653 ; ABA72653 ; Pfl01_0910 .
GeneIDi 3715813.
KEGGi pfo:Pfl01_0910.
PATRICi 19883897. VBIPseFlu44242_0925.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi TTETHKL.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci PFLU205922:GJBD-928-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiHGD_PSEPF
AccessioniPrimary (citable) accession number: Q3KHV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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