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Q3KHV3 (HGD_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:Pfl01_0910
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000225792

Sites

Metal binding3291Iron By similarity
Metal binding3351Iron By similarity
Metal binding3651Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KHV3 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 796796E8D13A483B

FASTA43147,490
        10         20         30         40         50         60 
MNLDSALAYQ SGFGNEFSSE ALPGALPVGQ NSPQKAPYGL YTELFSGTAF TMTRSEARRT 

        70         80         90        100        110        120 
WMYRIQPSAN HPAFVKLERQ LAGGPLGEVT PNRLRWNPLD LPTEPTDFID GLVSMAANSG 

       130        140        150        160        170        180 
ADKPAGISIY HYGANRSMER VFFNADGELL LVPQLGRLRI ATELGVLDVA PLEIAVLPRG 

       190        200        210        220        230        240 
LKFRVELLDP QARGYVAENH GAPLRLPDLG PIGSNGLANP RDFLTPVAAY ENLQQPTTLV 

       250        260        270        280        290        300 
QKFLGQLWGT ELNHSPLNVV AWHGNNVPYK YDLRRFNTIG TVSFDHPDPS IFTVLTSPTS 

       310        320        330        340        350        360 
VHGLANLDFV IFPPRWMVAE NTFRPPWFHR NLMNEFMGLI QGEYDAKAEG FVPGGASLHS 

       370        380        390        400        410        420 
CMSAHGPDGE TCTKAINADL KPAKIDNTMA FMFETSQVLR PSRFALDCPQ LQSTYDACWA 

       430 
TLPATFDPTR R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000094 Genomic DNA. Translation: ABA72653.1.
RefSeqYP_346642.1. NC_007492.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205922.Pfl01_0910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA72653; ABA72653; Pfl01_0910.
GeneID3715813.
KEGGpfo:Pfl01_0910.
PATRIC19883897. VBIPseFlu44242_0925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycPFLU205922:GJBD-928-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_PSEPF
AccessionPrimary (citable) accession number: Q3KHV3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways