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Q3KHV3

- HGD_PSEPF

UniProt

Q3KHV3 - HGD_PSEPF

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei286 – 2861Proton acceptorUniRule annotation
    Metal bindingi329 – 3291IronUniRule annotation
    Metal bindingi335 – 3351IronUniRule annotation
    Binding sitei344 – 3441homogentisateUniRule annotation
    Metal bindingi365 – 3651IronUniRule annotation
    Binding sitei365 – 3651homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-928-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:Pfl01_0910
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Homogentisate 1,2-dioxygenasePRO_0000225792Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi205922.Pfl01_0910.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiTTETHKL.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3KHV3-1 [UniParc]FASTAAdd to Basket

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    MNLDSALAYQ SGFGNEFSSE ALPGALPVGQ NSPQKAPYGL YTELFSGTAF    50
    TMTRSEARRT WMYRIQPSAN HPAFVKLERQ LAGGPLGEVT PNRLRWNPLD 100
    LPTEPTDFID GLVSMAANSG ADKPAGISIY HYGANRSMER VFFNADGELL 150
    LVPQLGRLRI ATELGVLDVA PLEIAVLPRG LKFRVELLDP QARGYVAENH 200
    GAPLRLPDLG PIGSNGLANP RDFLTPVAAY ENLQQPTTLV QKFLGQLWGT 250
    ELNHSPLNVV AWHGNNVPYK YDLRRFNTIG TVSFDHPDPS IFTVLTSPTS 300
    VHGLANLDFV IFPPRWMVAE NTFRPPWFHR NLMNEFMGLI QGEYDAKAEG 350
    FVPGGASLHS CMSAHGPDGE TCTKAINADL KPAKIDNTMA FMFETSQVLR 400
    PSRFALDCPQ LQSTYDACWA TLPATFDPTR R 431
    Length:431
    Mass (Da):47,490
    Last modified:November 8, 2005 - v1
    Checksum:i796796E8D13A483B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA72653.1.
    RefSeqiWP_011332514.1. NC_007492.2.
    YP_346642.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA72653; ABA72653; Pfl01_0910.
    GeneIDi3715813.
    KEGGipfo:Pfl01_0910.
    PATRICi19883897. VBIPseFlu44242_0925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA72653.1 .
    RefSeqi WP_011332514.1. NC_007492.2.
    YP_346642.1. NC_007492.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_0910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA72653 ; ABA72653 ; Pfl01_0910 .
    GeneIDi 3715813.
    KEGGi pfo:Pfl01_0910.
    PATRICi 19883897. VBIPseFlu44242_0925.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi TTETHKL.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci PFLU205922:GJBD-928-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiHGD_PSEPF
    AccessioniPrimary (citable) accession number: Q3KHV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3