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Q3KH99

- LPXB_PSEPF

UniProt

Q3KH99 - LPXB_PSEPF

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-1133-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Pfl01_1114
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Lipid-A-disaccharide synthasePRO_0000255208Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205922.Pfl01_1114.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3KH99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3KH99-1 [UniParc]FASTAAdd to Basket

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    MANLRIALVA GEASGDILGA GLMRALKAQH PAVEFIGVGG PLMQAEGLTS    50
    YFPMERLSVM GLVEVLGRLR ELLKRRKDLI ATLIAEKPDV FIGIDAPDFN 100
    LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
    YEEKGVPVRF VGHTLADTIP LEADRAAARA ELGLPDGPLV ALMPGSRGGE 200
    VSRLGALFLD TAQRLRAMRP GVRFVIPCAN PERRAQLEEL LAGRDLPVTL 250
    LDGKSHLALA ACNAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM 300
    VKSPYVSLPN LLAQRLLVPE LLQDDATVEA LAQTLSPLID GGEEQTRGFD 350
    EIHRTLRLDA SNQAADAVLN LIGQTR 376
    Length:376
    Mass (Da):41,122
    Last modified:November 8, 2005 - v1
    Checksum:i210608308C4FD267
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA72857.1.
    RefSeqiWP_011332691.1. NC_007492.2.
    YP_346846.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA72857; ABA72857; Pfl01_1114.
    GeneIDi3716538.
    KEGGipfo:Pfl01_1114.
    PATRICi19884319. VBIPseFlu44242_1136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA72857.1 .
    RefSeqi WP_011332691.1. NC_007492.2.
    YP_346846.1. NC_007492.2.

    3D structure databases

    ProteinModelPortali Q3KH99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_1114.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA72857 ; ABA72857 ; Pfl01_1114 .
    GeneIDi 3716538.
    KEGGi pfo:Pfl01_1114.
    PATRICi 19884319. VBIPseFlu44242_1136.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PFLU205922:GJBD-1133-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiLPXB_PSEPF
    AccessioniPrimary (citable) accession number: Q3KH99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3