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Q3KH99 (LPXB_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Pfl01_1114
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255208

Sequences

Sequence LengthMass (Da)Tools
Q3KH99 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 210608308C4FD267

FASTA37641,122
        10         20         30         40         50         60 
MANLRIALVA GEASGDILGA GLMRALKAQH PAVEFIGVGG PLMQAEGLTS YFPMERLSVM 

        70         80         90        100        110        120 
GLVEVLGRLR ELLKRRKDLI ATLIAEKPDV FIGIDAPDFN LNIELKLRQA GIKTVHYVSP 

       130        140        150        160        170        180 
SVWAWRQKRV LKIREGCDLM LTLLPFEARF YEEKGVPVRF VGHTLADTIP LEADRAAARA 

       190        200        210        220        230        240 
ELGLPDGPLV ALMPGSRGGE VSRLGALFLD TAQRLRAMRP GVRFVIPCAN PERRAQLEEL 

       250        260        270        280        290        300 
LAGRDLPVTL LDGKSHLALA ACNAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM 

       310        320        330        340        350        360 
VKSPYVSLPN LLAQRLLVPE LLQDDATVEA LAQTLSPLID GGEEQTRGFD EIHRTLRLDA 

       370 
SNQAADAVLN LIGQTR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000094 Genomic DNA. Translation: ABA72857.1.
RefSeqYP_346846.1. NC_007492.2.

3D structure databases

ProteinModelPortalQ3KH99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205922.Pfl01_1114.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA72857; ABA72857; Pfl01_1114.
GeneID3716538.
KEGGpfo:Pfl01_1114.
PATRIC19884319. VBIPseFlu44242_1136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycPFLU205922:GJBD-1133-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_PSEPF
AccessionPrimary (citable) accession number: Q3KH99
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways