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Q3KH99

- LPXB_PSEPF

UniProt

Q3KH99 - LPXB_PSEPF

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-1133-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Pfl01_1114
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Lipid-A-disaccharide synthasePRO_0000255208Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205922.Pfl01_1114.

Structurei

3D structure databases

ProteinModelPortaliQ3KH99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3KH99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANLRIALVA GEASGDILGA GLMRALKAQH PAVEFIGVGG PLMQAEGLTS
60 70 80 90 100
YFPMERLSVM GLVEVLGRLR ELLKRRKDLI ATLIAEKPDV FIGIDAPDFN
110 120 130 140 150
LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF
160 170 180 190 200
YEEKGVPVRF VGHTLADTIP LEADRAAARA ELGLPDGPLV ALMPGSRGGE
210 220 230 240 250
VSRLGALFLD TAQRLRAMRP GVRFVIPCAN PERRAQLEEL LAGRDLPVTL
260 270 280 290 300
LDGKSHLALA ACNAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM
310 320 330 340 350
VKSPYVSLPN LLAQRLLVPE LLQDDATVEA LAQTLSPLID GGEEQTRGFD
360 370
EIHRTLRLDA SNQAADAVLN LIGQTR
Length:376
Mass (Da):41,122
Last modified:November 8, 2005 - v1
Checksum:i210608308C4FD267
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA72857.1.
RefSeqiWP_011332691.1. NC_007492.2.
YP_346846.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA72857; ABA72857; Pfl01_1114.
GeneIDi3716538.
KEGGipfo:Pfl01_1114.
PATRICi19884319. VBIPseFlu44242_1136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA72857.1 .
RefSeqi WP_011332691.1. NC_007492.2.
YP_346846.1. NC_007492.2.

3D structure databases

ProteinModelPortali Q3KH99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_1114.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA72857 ; ABA72857 ; Pfl01_1114 .
GeneIDi 3716538.
KEGGi pfo:Pfl01_1114.
PATRICi 19884319. VBIPseFlu44242_1136.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PFLU205922:GJBD-1133-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiLPXB_PSEPF
AccessioniPrimary (citable) accession number: Q3KH99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3