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Q3KGE4 (ACEK_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase kinase/phosphatase
Short name=IDH kinase/phosphatase
Short name=IDHK/P
EC=2.7.11.5
EC=3.1.3.-
Gene names
Name:aceK
Ordered Locus Names:Pfl01_1419
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation By similarity. HAMAP MF_00747

Catalytic activity

ATP + [isocitrate dehydrogenase (NADP+)] = ADP + [isocitrate dehydrogenase (NADP+)] phosphate. HAMAP MF_00747

Subcellular location

Cytoplasm By similarity HAMAP MF_00747.

Sequence similarities

Belongs to the AceK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Isocitrate dehydrogenase kinase/phosphatase HAMAP MF_00747
PRO_0000259154

Regions

Nucleotide binding317 – 3237ATP By similarity

Sites

Active site3731 By similarity
Binding site3381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3KGE4 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: C0BEDFB09A478D85

FASTA57366,062
        10         20         30         40         50         60 
MPQQWPATDI ARLILDGFDD YREHFRRITD GARERFEQAR WQDTQTASAA RINLYEEKVG 

        70         80         90        100        110        120 
ETVARLREYF EPDTLMDVTC WPLVKSAYIS IIDLRFDDEL SETWYNSIFC SLFSHDLISD 

       130        140        150        160        170        180 
GCMFIHTTRP SLRRARAAQT RTYKPQGQIS GMLASIFADY RFSEAYADLP GDLLRLEAQL 

       190        200        210        220        230        240 
RENLPDWVCK DPELSVELFS SVLYRNKGAY LVGRIYTNDD QWPLVIPLLH REGRGIQIDA 

       250        260        270        280        290        300 
LITDEAEVSI IFSFTRSYFM VDVPVPAEFI GFLKRILPGK HIAELYTSIG FYKHGKSEFY 

       310        320        330        340        350        360 
RALINHLANT DDQFIMAPGV RGMVMSVFTL PGFNTVFKII KDRFSPSKNV DRATVIEKYR 

       370        380        390        400        410        420 
LVKSVDRVGR MADTQEFADF RFPLSKFEPA CLAELLEVAP STVSLEGETV LIRHCWTERR 

       430        440        450        460        470        480 
MTPLNLYLDN ANEAQVREAL EDYGLAIKQL AAANIFPGDM LLKNFGVTRH GRVVFYDYDE 

       490        500        510        520        530        540 
ICFLTEANFR HIPAPRTPED EMASEPWYSI GPLDVFPEEF PPFLFADAAQ RKLFDQLHGE 

       550        560        570 
LYNADYWKGL QEAIRAGKVI DVFPYRRKGL DNE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000094 Genomic DNA. Translation: ABA73162.1.
RefSeqYP_347151.1. NC_007492.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ3KGE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3717175.
GenomeReviewsGene locus Pfl01_1419 in contig CP000094_GR.
KEGGpfo:Pfl01_1419.
PATRIC19884943. VBIPseFlu44242_1444.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4579.
HOGENOMHBG298593.
OMARMTPLNI.
ProtClustDBPRK02946.

Enzyme and pathway databases

BioCycPFLU205922:PFL_1419-MONOMER.

Family and domain databases

HAMAPMF_00747. AceK.
[Tree]
InterProIPR010452. Isocitrate_DH_AceK.
[Graphical view]
KOK00906.
PfamPF06315. AceK. 1 hit.
[Graphical view]
PIRSFPIRSF000719. AceK. 1 hit.
ProDomPD043552. Isocitrate_DH_AceK. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameACEK_PSEPF
AccessionPrimary (citable) accession number: Q3KGE4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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