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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2

Gene

arnT2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathway: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-2891-MONOMER.
UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2UniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 2UniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferase 2UniRule annotation
Gene namesi
Name:arnT2UniRule annotation
Ordered Locus Names:Pfl01_2845
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10223HelicalUniRule annotationAdd
BLAST
Transmembranei112 – 13221HelicalUniRule annotationAdd
BLAST
Transmembranei133 – 15321HelicalUniRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalUniRule annotationAdd
BLAST
Transmembranei204 – 22421HelicalUniRule annotationAdd
BLAST
Transmembranei259 – 27921HelicalUniRule annotationAdd
BLAST
Transmembranei290 – 31021HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33221HelicalUniRule annotationAdd
BLAST
Transmembranei342 – 36221HelicalUniRule annotationAdd
BLAST
Transmembranei377 – 39721HelicalUniRule annotationAdd
BLAST
Transmembranei402 – 42221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2PRO_0000380022Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205922.Pfl01_2845.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1807.
HOGENOMiHOG000273002.
KOiK07264.
OMAiWLAAAMC.
OrthoDBiEOG6NKQWN.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3KCB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRWALPLL LGIFLLAYLL PLGSHGLWIP DETRYAQISQ EMLLSGNWVS
60 70 80 90 100
PHFMNLRYFE KPAAGYWMIA IGQAVFGQNL FGVRFASALS TGLSVLLCFL
110 120 130 140 150
IARRLWNEPR KSFVCALLYM SFVIVAGQAG YANLDPQFTF WVNLSLVALW
160 170 180 190 200
FALDSRANGQ RLAGWAVLGL ACGMGFMTKG FLAWLLPVLI ALPWMLWQKR
210 220 230 240 250
WKELLLYGPV AIAVAIIVSL PWALAVHGQE PDYWRFFFWH EHIRRFAGDD
260 270 280 290 300
AQHDAPWWFY LPLLVAFSLP WVGMLPVAFK QAWQTRRETG IAFLGLWLLM
310 320 330 340 350
PLLFFSLSNG KLPTYILPCL LPLALLLGHA LADRLRLEQG RALGLNGLLN
360 370 380 390 400
LLLGLVTLIG LVYVQLKRPL YDHELHSLVL VFIALTGWII SNLLQAFRPL
410 420 430 440 450
QCWAAPAVGS LLLIALLPAA LPRSVVANKM PDQFVLAHQK ELTATTHLLS
460 470 480 490 500
NDLGAASALS WRVKRPQVAL YNTIGELKYG LAYPDGIQQR VDPDQVQQWM
510 520 530 540
REARKTGSVG VVMRVKGQDE LDELDRLPKD GVRYEQGNLV IMILPQEAS
Length:549
Mass (Da):61,799
Last modified:November 8, 2005 - v1
Checksum:iBE48FCA63666F866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA74586.1.
RefSeqiWP_011334257.1. NC_007492.2.
YP_348576.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA74586; ABA74586; Pfl01_2845.
KEGGipfo:Pfl01_2845.
PATRICi19887851. VBIPseFlu44242_2878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA74586.1.
RefSeqiWP_011334257.1. NC_007492.2.
YP_348576.1. NC_007492.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205922.Pfl01_2845.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA74586; ABA74586; Pfl01_2845.
KEGGipfo:Pfl01_2845.
PATRICi19887851. VBIPseFlu44242_2878.

Phylogenomic databases

eggNOGiCOG1807.
HOGENOMiHOG000273002.
KOiK07264.
OMAiWLAAAMC.
OrthoDBiEOG6NKQWN.

Enzyme and pathway databases

UniPathwayiUPA00037.
BioCyciPFLU205922:GJBD-2891-MONOMER.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiARNT2_PSEPF
AccessioniPrimary (citable) accession number: Q3KCB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 8, 2005
Last modified: May 27, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.