Reviewed, UniProtKB/Swiss-Prot Q3KC83 (NUDC_PSEPF)

Names and origin

Protein names

Recommended name:
    NADH pyrophosphatase
    EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	Pfl01_2881

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP MF_00297
Cofactor	Divalent ions. Manganese or magnesium By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily.

Ontologies

Keywords
Ligand	Magnesium Manganese NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	NADH pyrophosphatase HAMAP MF_00297		PRO_1000071962
Regions
	Motif	173 – 194	22	Nudix box HAMAP MF_00297

Sequences

	Sequence		Length	Mass (Da)
	Q3KC83-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 5A4DDCA0FBE27236	FASTA	276	31,000
	10 20 30 40 50 60 MTSRWTTAVL DTDQPGGWAV ARSPEGFLFD DNGVLFPREW LKRQDLSILA EHGIGHLDGE 70 80 90 100 110 120 PVYLLELHST SEVPGCNWKG LRAFMLDGDH TIYKVLGYAA QIGTWAREHR FCGNCGQAMT 130 140 150 160 170 180 QVPRERAMYC QPCDLRSYPR ISPSMIVLVT RGDEVLLARS PRFVTGVYST LAGFAEPGES 190 200 210 220 230 240 AEDCLIREVR EEVQIEVKNI QYMGSQCWPF PHSMMLGFHA EYAGGEIVCQ EDEIEDAQWF 250 260 270 NVHDLPPLPA SKSIARYLID VYVARRLGHA EPVLPG

References

[1]

"Complete sequence of Pseudomonas fluorescens PfO-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyripides N., Anderson I., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000094 Genomic DNA. Translation: ABA74622.1.
RefSeq	YP_348612.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3712429.
GenomeReviews	Gene locus Pfl01_2881 in contig CP000094_GR.
KEGG	pfo:Pfl01_2881.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3KC83.
OMA	Q3KC83. TWAREHR.
Enzyme and pathway databases
BioCyc	PFLU205922:PFL_2881-MON.
Family and domain databases
HAMAP	MF_00297. [Tree]
InterPro	IPR015375. NADH_PPase-like_N. IPR000086. NUDIX_hydrolase_core. IPR015376. Znr_NADH_PPase. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_PSEPF

Accession

Primary (citable) accession number: Q3KC83

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 8, 2005
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)