Reviewed,
UniProtKB/Swiss-Prot Q3K9J0 (UPPP2_PSEPF)
Last modified
February 9, 2010.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Undecaprenyl-diphosphatase 2 EC=3.6.1.27 Alternative name(s): Undecaprenyl pyrophosphate phosphatase 2 Bacitracin resistance protein 2 | ||||
| Gene names |
| ||||
| Organism | Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 205922 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas |
Protein attributes
| Sequence length | 277 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006 |
| Catalytic activity | Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006 |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006. |
| Miscellaneous | Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006 |
| Sequence similarities | Belongs to the uppP family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylationInferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW response to antibioticInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 277 | 277 | Undecaprenyl-diphosphatase 2 HAMAP MF_01006 | PRO_0000227631 | |||||
Regions | |||||||||
| Transmembrane | 43 – 63 | 21 | Potential | ||||||
| Transmembrane | 87 – 107 | 21 | Potential | ||||||
| Transmembrane | 109 – 129 | 21 | Potential | ||||||
| Transmembrane | 183 – 203 | 21 | Potential | ||||||
| Transmembrane | 214 – 234 | 21 | Potential | ||||||
| Transmembrane | 254 – 274 | 21 | Potential | ||||||
Sequences
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References
| [1] | "Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens." Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R., Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M., Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J., Harris S., Challis G.L., Yaxley A.M., Harris D. Thomson N.R.Genome Biol. 10:R51.1-R51.16(2009) [PubMed: 19432983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000094 Genomic DNA. Translation: ABA75564.1. |
| RefSeq | YP_349555.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3K9J0. |
Genome annotation databases | |
| GeneID | 3714854. |
| GenomeReviews | Gene locus Pfl01_3826 in contig CP000094_GR. |
| KEGG | pfo:Pfl01_3826. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1968. |
| HOGENOM | HBG391969. |
| OMA | VQCLSLW. |
Enzyme and pathway databases | |
| BioCyc | PFLU205922:PFL_3826-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01006. Undec_diphosphatase. [Tree] |
| InterPro | IPR003824. Bacitracin-R_BacA. [Graphical view] |
| Pfam | PF02673. BacA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00753. undec_PP_bacA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UPPP2_PSEPF | ||||||||
| Accession | Primary (citable) accession number: Q3K9J0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


