Reviewed, UniProtKB/Swiss-Prot Q3K9J0 (UPPP2_PSEPF)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	Pfl01_3826

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000227631
Regions
	Transmembrane	43 – 63	21	Potential
	Transmembrane	87 – 107	21	Potential
	Transmembrane	109 – 129	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	214 – 234	21	Potential
	Transmembrane	254 – 274	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3K9J0-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 3454560A3AACE8EF	FASTA	277	30,394
	10 20 30 40 50 60 MDLLTLFKVL ILGAVEGLTE FLPISSTGHQ IIVADLLEFG GERAMAFNII IQLGAILAVV 70 80 90 100 110 120 WEFRPKIFEI VKGLPTQSNA QRFTRNLLIA FFPAVILGVL FADTIHEYLF NPITVAVALV 130 140 150 160 170 180 VGGIVMLWAE QRDHVVSVDH VDDMKWADAL KIGCVQCLAM IPGTSRSGST IIGGLLFGLS 190 200 210 220 230 240 RKAATEFSFF LAMPTMVGAA VYSGYKYREL FQSSDLPVFA LGFVVAFIFA MIAVRGLLKF 250 260 270 IANHSYATFA WYRIAFGLLI LATWQFGWVN WTAAAAA

References

[1]

"Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens." Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R., Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M., Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J., Harris S., Challis G.L., Yaxley A.M., Harris D. , Seeger K., Murphy L., Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K., Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M., Parkhill J., Levy S.B., Rainey P.B., Thomson N.R. Genome Biol. 10:R51.1-R51.16(2009) [PubMed: 19432983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000094 Genomic DNA. Translation: ABA75564.1.
RefSeq	YP_349555.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3K9J0.
Genome annotation databases
GeneID	3714854.
GenomeReviews	Gene locus Pfl01_3826 in contig CP000094_GR.
KEGG	pfo:Pfl01_3826.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	VQCLSLW.
Enzyme and pathway databases
BioCyc	PFLU205922:PFL_3826-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_PSEPF

Accession

Primary (citable) accession number: Q3K9J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)