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Q3K9J0

- UPPP2_PSEPF

UniProt

Q3K9J0 - UPPP2_PSEPF

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-3876-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Ordered Locus Names:Pfl01_3826
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Undecaprenyl-diphosphatase 2PRO_0000227631Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205922.Pfl01_3826.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei183 – 20321HelicalUniRule annotationAdd
    BLAST
    Transmembranei214 – 23421HelicalUniRule annotationAdd
    BLAST
    Transmembranei254 – 27421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFMNMFEY.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3K9J0-1 [UniParc]FASTAAdd to Basket

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    MDLLTLFKVL ILGAVEGLTE FLPISSTGHQ IIVADLLEFG GERAMAFNII    50
    IQLGAILAVV WEFRPKIFEI VKGLPTQSNA QRFTRNLLIA FFPAVILGVL 100
    FADTIHEYLF NPITVAVALV VGGIVMLWAE QRDHVVSVDH VDDMKWADAL 150
    KIGCVQCLAM IPGTSRSGST IIGGLLFGLS RKAATEFSFF LAMPTMVGAA 200
    VYSGYKYREL FQSSDLPVFA LGFVVAFIFA MIAVRGLLKF IANHSYATFA 250
    WYRIAFGLLI LATWQFGWVN WTAAAAA 277
    Length:277
    Mass (Da):30,394
    Last modified:November 8, 2005 - v1
    Checksum:i3454560A3AACE8EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA75564.1.
    RefSeqiYP_349555.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA75564; ABA75564; Pfl01_3826.
    GeneIDi3714854.
    KEGGipfo:Pfl01_3826.
    PATRICi19889751. VBIPseFlu44242_3820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA75564.1 .
    RefSeqi YP_349555.1. NC_007492.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_3826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA75564 ; ABA75564 ; Pfl01_3826 .
    GeneIDi 3714854.
    KEGGi pfo:Pfl01_3826.
    PATRICi 19889751. VBIPseFlu44242_3820.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FMNMFEY.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PFLU205922:GJBD-3876-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiUPPP2_PSEPF
    AccessioniPrimary (citable) accession number: Q3K9J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3