Q3K935 (MSRB_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	Pfl01_3982

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000068288
Sites
	Active site	119	1	Nucleophile By similarity
	Metal binding	47	1	Zinc By similarity
	Metal binding	50	1	Zinc By similarity
	Metal binding	96	1	Zinc By similarity
	Metal binding	99	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3K935 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 211A36D8A5C64B38	FASTA	131	14,753
	10 20 30 40 50 60 MEKIEKTLEE WRAMLDPEQF NVCRLSATER PFSGKYNATK TDGVYHCICC NEPLFDSKTK 70 80 90 100 110 120 FDSGCGWPSF YAPIGDNAMT EIRDTSHGMI RTEVKCAKCD AHLGHVFPDG PPPTGLRYCI 130 NSVCLDLVPR E

References

[1]

"Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens." Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R., Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M., Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J., Harris S., Challis G.L., Yaxley A.M., Harris D. , Seeger K., Murphy L., Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K., Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M., Parkhill J., Levy S.B., Rainey P.B., Thomson N.R. Genome Biol. 10:R51.1-R51.16(2009) [PubMed: 19432983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pf0-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000094 Genomic DNA. Translation: ABA75719.1.
RefSeq	YP_349710.1. NC_007492.2.
3D structure databases
ProteinModelPortal	Q3K935.
SMR	Q3K935. Positions 4-131.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3K935.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3714008.
GenomeReviews	Gene locus Pfl01_3982 in contig CP000094_GR.
KEGG	pfo:Pfl01_3982.
PATRIC	19890081. VBIPseFlu44242_3980.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	LFESATK.
PhylomeDB	Q3K935.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	PFLU205922:PFL_3982-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_PSEPF

Accession

Primary (citable) accession number: Q3K935

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program