ID   TPMT_PSEPF              Reviewed;         217 AA.
AC   Q3K932;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Thiopurine S-methyltransferase;
DE            EC=2.1.1.67;
DE   AltName: Full=Thiopurine methyltransferase;
GN   Name=tpm; OrderedLocusNames=Pfl01_3985;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyripides N., Anderson I., Richardson P.;
RT   "Complete sequence of Pseudomonas fluorescens PfO-1.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + a thiopurine = S-
CC       adenosyl-L-homocysteine + a thiopurine S-methylether.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. TPMT
CC       family.
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DR   EMBL; CP000094; ABA75722.1; -; Genomic_DNA.
DR   RefSeq; YP_349713.1; -.
DR   GeneID; 3714011; -.
DR   GenomeReviews; CP000094_GR; Pfl01_3985.
DR   KEGG; pfo:Pfl01_3985; -.
DR   HOGENOM; Q3K932; -.
DR   OMA; Q3K932; PPFAVSP.
DR   BioCyc; PFLU205922:PFL_3985-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008119; F:thiopurine S-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   HAMAP; MF_00812; -; 1.
DR   InterPro; IPR008854; Thiopurine_S-MeTrfase.
DR   InterPro; IPR016822; Thiopurine_S-MeTrfase_sub.
DR   Pfam; PF05724; TPMT; 1.
DR   PIRSF; PIRSF023956; Thiopurine_S-methyltransferase; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    217       Thiopurine S-methyltransferase.
FT                                /FTId=PRO_1000047214.
FT   BINDING      10     10       S-adenosyl-L-methionine (By similarity).
FT   BINDING      45     45       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen (By similarity).
FT   BINDING      66     66       S-adenosyl-L-methionine (By similarity).
FT   BINDING     123    123       S-adenosyl-L-methionine (By similarity).
SQ   SEQUENCE   217 AA;  24762 MW;  BF10193406CA7382 CRC64;
     MQPEFWHKKW ESNQIGFHQL EVNPYLQRHW PDLAIPVQAR VLVPLCGKSL DLLWLAGRGH
     QVLGVELSEK AVEDFFHEQQ LQPQVSEQGD FKVYRADAVE LWCGDFFSLT MADVAGCTAL
     YDRAAVIALP PAMRERYAAH LQSILPACRG LLVTLDYDQS QMPGPPFSVD DAEVQRLLGS
     VWRVEMLEQQ DVLGDSWKFV QAGVTRLEER VYRIRGV
//