ID   GCSP1_PSEPF             Reviewed;         950 AA.
AC   Q3K7X5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Glycine dehydrogenase [decarboxylating] 1;
DE            EC=1.4.4.2;
DE   AltName: Full=Glycine decarboxylase 1;
DE   AltName: Full=Glycine cleavage system P-protein 1;
GN   Name=gcvP1; OrderedLocusNames=Pfl01_4392;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyripides N., Anderson I., Richardson P.;
RT   "Complete sequence of Pseudomonas fluorescens PfO-1.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine
CC       through its pyridoxal phosphate cofactor; CO(2) is released and
CC       the remaining methylamine moiety is then transferred to the
CC       lipoamide cofactor of the H protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-
CC       S-aminomethyldihydrolipoyllysine + CO(2).
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins:
CC       P, T, L and H (By similarity).
CC   -!- SIMILARITY: Belongs to the gcvP family.
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DR   EMBL; CP000094; ABA76129.1; -; Genomic_DNA.
DR   RefSeq; YP_350120.1; -.
DR   GeneID; 3712835; -.
DR   GenomeReviews; CP000094_GR; Pfl01_4392.
DR   KEGG; pfo:Pfl01_4392; -.
DR   HOGENOM; Q3K7X5; -.
DR   OMA; Q3K7X5; PETIMIE.
DR   BioCyc; PFLU205922:PFL_4392-MON; -.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) act...; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavag...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00711; -; 1.
DR   InterPro; IPR003437; GDC-P.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   Gene3D; G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
DR   PANTHER; PTHR11773; GDC-P; 1.
DR   Pfam; PF02347; GDC-P; 1.
DR   TIGRFAMs; TIGR00461; gcvP; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Pyridoxal phosphate.
FT   CHAIN         1    950       Glycine dehydrogenase [decarboxylating]
FT                                1.
FT                                /FTId=PRO_0000227118.
FT   MOD_RES     704    704       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   950 AA;  102581 MW;  C03E37A90AFB210C CRC64;
     MTQVNLGTAN EFIARHIGPR AGDEQAMLNS LGFDSLEALS ASVIPESIKG TSVLGLDDGL
     SEADALAMIK GIAGKNQLFK TYIGQGYYNC HTPSPILRNL LENPAWYTAY TPYQPEISQG
     RLEALLNFQT LISDLTGLPI ANASLLDEAT AAAEAMTFCK RLSKNKGSHQ FFASIHSHTQ
     TLDVLRTRAE PLGIDVVVGD ERELTDVTPF FGALLQYPAS NGDVFDYREL TERFHAANAL
     VAVAADLLAL TLLTPPGEFG ADVAIGSAQR FGVPLGFGGP HAAYFSTKDA FKRDMPGRLV
     GVSVDRFGKP ALRLAMQTRE QHIRREKATS NICTAQVLLA NIASMYAVYH GPKGLTQIAN
     RVHHLTAILA KGLSALGVTV EQTSFFDTLT LATGAQTAAL HDKARAQQIN LRVIDAQRLG
     LSVDETTTQA DIETLWGLFA DGKTLPDFAA LAAAAQSTIP ASLVRQSPIL SHPVFNRYHS
     ETELMRYLRK LADKDLALDR TMIPLGSCTM KLNAASEMIP VTWAEFGALH PFAPAEQSAG
     YQQLTDELEA MLCAATGYDS ISLQPNAGSQ GEYAGLLAIR AYHQSRGEDR RDICLIPSSA
     HGTNPATANM AGMRVVVTAC DARGNVDIED LRAKAIEHRE HLAALMITYP STHGVFEEGI
     REICGIIHDN GGQVYIDGAN MNAMVGLCAP GKFGGDVSHL NLHKTFCIPH GGGGPGVGPI
     GVKSHLTPFL PGHGHMERKE GAVCAAPFGS ASILPITWMY IRMMGGAGLK RASQLAILNA
     NYISRRLEEH YPVLYTGSNG LVAHECILDL RPLKDSSGIS VDDVAKRLID FGFHAPTMSF
     PVAGTLMIEP TESESKEELD RFCDAMIRIR EEIRAVENGT LDKDDNPLKN APHTAAELVG
     EWTHPYSREQ AVYPVASLIE GKYWPPVGRV DNVFGDRNLV CACPSIESYA
//