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Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-4457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein 1UniRule annotation
Glycine decarboxylase 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) 1UniRule annotation
Gene namesi
Name:gcvP1UniRule annotation
Ordered Locus Names:Pfl01_4392
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating) 1PRO_0000227118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi205922.Pfl01_4392.

Structurei

3D structure databases

ProteinModelPortaliQ3K7X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K7X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVNLGTAN EFIARHIGPR AGDEQAMLNS LGFDSLEALS ASVIPESIKG
60 70 80 90 100
TSVLGLDDGL SEADALAMIK GIAGKNQLFK TYIGQGYYNC HTPSPILRNL
110 120 130 140 150
LENPAWYTAY TPYQPEISQG RLEALLNFQT LISDLTGLPI ANASLLDEAT
160 170 180 190 200
AAAEAMTFCK RLSKNKGSHQ FFASIHSHTQ TLDVLRTRAE PLGIDVVVGD
210 220 230 240 250
ERELTDVTPF FGALLQYPAS NGDVFDYREL TERFHAANAL VAVAADLLAL
260 270 280 290 300
TLLTPPGEFG ADVAIGSAQR FGVPLGFGGP HAAYFSTKDA FKRDMPGRLV
310 320 330 340 350
GVSVDRFGKP ALRLAMQTRE QHIRREKATS NICTAQVLLA NIASMYAVYH
360 370 380 390 400
GPKGLTQIAN RVHHLTAILA KGLSALGVTV EQTSFFDTLT LATGAQTAAL
410 420 430 440 450
HDKARAQQIN LRVIDAQRLG LSVDETTTQA DIETLWGLFA DGKTLPDFAA
460 470 480 490 500
LAAAAQSTIP ASLVRQSPIL SHPVFNRYHS ETELMRYLRK LADKDLALDR
510 520 530 540 550
TMIPLGSCTM KLNAASEMIP VTWAEFGALH PFAPAEQSAG YQQLTDELEA
560 570 580 590 600
MLCAATGYDS ISLQPNAGSQ GEYAGLLAIR AYHQSRGEDR RDICLIPSSA
610 620 630 640 650
HGTNPATANM AGMRVVVTAC DARGNVDIED LRAKAIEHRE HLAALMITYP
660 670 680 690 700
STHGVFEEGI REICGIIHDN GGQVYIDGAN MNAMVGLCAP GKFGGDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGVGPI GVKSHLTPFL PGHGHMERKE GAVCAAPFGS
760 770 780 790 800
ASILPITWMY IRMMGGAGLK RASQLAILNA NYISRRLEEH YPVLYTGSNG
810 820 830 840 850
LVAHECILDL RPLKDSSGIS VDDVAKRLID FGFHAPTMSF PVAGTLMIEP
860 870 880 890 900
TESESKEELD RFCDAMIRIR EEIRAVENGT LDKDDNPLKN APHTAAELVG
910 920 930 940 950
EWTHPYSREQ AVYPVASLIE GKYWPPVGRV DNVFGDRNLV CACPSIESYA
Length:950
Mass (Da):102,581
Last modified:November 8, 2005 - v1
Checksum:iC03E37A90AFB210C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA76129.1.
RefSeqiWP_011335631.1. NC_007492.2.
YP_350120.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA76129; ABA76129; Pfl01_4392.
KEGGipfo:Pfl01_4392.
PATRICi19890936. VBIPseFlu44242_4396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA76129.1.
RefSeqiWP_011335631.1. NC_007492.2.
YP_350120.1. NC_007492.2.

3D structure databases

ProteinModelPortaliQ3K7X5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205922.Pfl01_4392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA76129; ABA76129; Pfl01_4392.
KEGGipfo:Pfl01_4392.
PATRICi19890936. VBIPseFlu44242_4396.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-4457-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiGCSP1_PSEPF
AccessioniPrimary (citable) accession number: Q3K7X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.