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Q3K7X5

- GCSP1_PSEPF

UniProt

Q3K7X5 - GCSP1_PSEPF

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Protein

Glycine dehydrogenase (decarboxylating) 1

Gene
gcvP1, Pfl01_4392
Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-4457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene namesi
Name:gcvP1
Ordered Locus Names:Pfl01_4392
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating) 1UniRule annotationPRO_0000227118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi205922.Pfl01_4392.

Structurei

3D structure databases

ProteinModelPortaliQ3K7X5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K7X5-1 [UniParc]FASTAAdd to Basket

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MTQVNLGTAN EFIARHIGPR AGDEQAMLNS LGFDSLEALS ASVIPESIKG    50
TSVLGLDDGL SEADALAMIK GIAGKNQLFK TYIGQGYYNC HTPSPILRNL 100
LENPAWYTAY TPYQPEISQG RLEALLNFQT LISDLTGLPI ANASLLDEAT 150
AAAEAMTFCK RLSKNKGSHQ FFASIHSHTQ TLDVLRTRAE PLGIDVVVGD 200
ERELTDVTPF FGALLQYPAS NGDVFDYREL TERFHAANAL VAVAADLLAL 250
TLLTPPGEFG ADVAIGSAQR FGVPLGFGGP HAAYFSTKDA FKRDMPGRLV 300
GVSVDRFGKP ALRLAMQTRE QHIRREKATS NICTAQVLLA NIASMYAVYH 350
GPKGLTQIAN RVHHLTAILA KGLSALGVTV EQTSFFDTLT LATGAQTAAL 400
HDKARAQQIN LRVIDAQRLG LSVDETTTQA DIETLWGLFA DGKTLPDFAA 450
LAAAAQSTIP ASLVRQSPIL SHPVFNRYHS ETELMRYLRK LADKDLALDR 500
TMIPLGSCTM KLNAASEMIP VTWAEFGALH PFAPAEQSAG YQQLTDELEA 550
MLCAATGYDS ISLQPNAGSQ GEYAGLLAIR AYHQSRGEDR RDICLIPSSA 600
HGTNPATANM AGMRVVVTAC DARGNVDIED LRAKAIEHRE HLAALMITYP 650
STHGVFEEGI REICGIIHDN GGQVYIDGAN MNAMVGLCAP GKFGGDVSHL 700
NLHKTFCIPH GGGGPGVGPI GVKSHLTPFL PGHGHMERKE GAVCAAPFGS 750
ASILPITWMY IRMMGGAGLK RASQLAILNA NYISRRLEEH YPVLYTGSNG 800
LVAHECILDL RPLKDSSGIS VDDVAKRLID FGFHAPTMSF PVAGTLMIEP 850
TESESKEELD RFCDAMIRIR EEIRAVENGT LDKDDNPLKN APHTAAELVG 900
EWTHPYSREQ AVYPVASLIE GKYWPPVGRV DNVFGDRNLV CACPSIESYA 950
Length:950
Mass (Da):102,581
Last modified:November 8, 2005 - v1
Checksum:iC03E37A90AFB210C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA76129.1.
RefSeqiYP_350120.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA76129; ABA76129; Pfl01_4392.
GeneIDi3712835.
KEGGipfo:Pfl01_4392.
PATRICi19890936. VBIPseFlu44242_4396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA76129.1 .
RefSeqi YP_350120.1. NC_007492.2.

3D structure databases

ProteinModelPortali Q3K7X5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_4392.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA76129 ; ABA76129 ; Pfl01_4392 .
GeneIDi 3712835.
KEGGi pfo:Pfl01_4392.
PATRICi 19890936. VBIPseFlu44242_4396.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PFLU205922:GJBD-4457-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiGCSP1_PSEPF
AccessioniPrimary (citable) accession number: Q3K7X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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