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Q3K7X5 (GCSP1_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene names
Name:gcvP1
Ordered Locus Names:Pfl01_4392
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 950950Glycine dehydrogenase (decarboxylating) 1 HAMAP-Rule MF_00711
PRO_0000227118

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K7X5 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: C03E37A90AFB210C

FASTA950102,581
        10         20         30         40         50         60 
MTQVNLGTAN EFIARHIGPR AGDEQAMLNS LGFDSLEALS ASVIPESIKG TSVLGLDDGL 

        70         80         90        100        110        120 
SEADALAMIK GIAGKNQLFK TYIGQGYYNC HTPSPILRNL LENPAWYTAY TPYQPEISQG 

       130        140        150        160        170        180 
RLEALLNFQT LISDLTGLPI ANASLLDEAT AAAEAMTFCK RLSKNKGSHQ FFASIHSHTQ 

       190        200        210        220        230        240 
TLDVLRTRAE PLGIDVVVGD ERELTDVTPF FGALLQYPAS NGDVFDYREL TERFHAANAL 

       250        260        270        280        290        300 
VAVAADLLAL TLLTPPGEFG ADVAIGSAQR FGVPLGFGGP HAAYFSTKDA FKRDMPGRLV 

       310        320        330        340        350        360 
GVSVDRFGKP ALRLAMQTRE QHIRREKATS NICTAQVLLA NIASMYAVYH GPKGLTQIAN 

       370        380        390        400        410        420 
RVHHLTAILA KGLSALGVTV EQTSFFDTLT LATGAQTAAL HDKARAQQIN LRVIDAQRLG 

       430        440        450        460        470        480 
LSVDETTTQA DIETLWGLFA DGKTLPDFAA LAAAAQSTIP ASLVRQSPIL SHPVFNRYHS 

       490        500        510        520        530        540 
ETELMRYLRK LADKDLALDR TMIPLGSCTM KLNAASEMIP VTWAEFGALH PFAPAEQSAG 

       550        560        570        580        590        600 
YQQLTDELEA MLCAATGYDS ISLQPNAGSQ GEYAGLLAIR AYHQSRGEDR RDICLIPSSA 

       610        620        630        640        650        660 
HGTNPATANM AGMRVVVTAC DARGNVDIED LRAKAIEHRE HLAALMITYP STHGVFEEGI 

       670        680        690        700        710        720 
REICGIIHDN GGQVYIDGAN MNAMVGLCAP GKFGGDVSHL NLHKTFCIPH GGGGPGVGPI 

       730        740        750        760        770        780 
GVKSHLTPFL PGHGHMERKE GAVCAAPFGS ASILPITWMY IRMMGGAGLK RASQLAILNA 

       790        800        810        820        830        840 
NYISRRLEEH YPVLYTGSNG LVAHECILDL RPLKDSSGIS VDDVAKRLID FGFHAPTMSF 

       850        860        870        880        890        900 
PVAGTLMIEP TESESKEELD RFCDAMIRIR EEIRAVENGT LDKDDNPLKN APHTAAELVG 

       910        920        930        940        950 
EWTHPYSREQ AVYPVASLIE GKYWPPVGRV DNVFGDRNLV CACPSIESYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000094 Genomic DNA. Translation: ABA76129.1.
RefSeqYP_350120.1. NC_007492.2.

3D structure databases

ProteinModelPortalQ3K7X5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205922.Pfl01_4392.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA76129; ABA76129; Pfl01_4392.
GeneID3712835.
KEGGpfo:Pfl01_4392.
PATRIC19890936. VBIPseFlu44242_4396.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAAELMPVS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPFLU205922:GJBD-4457-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP1_PSEPF
AccessionPrimary (citable) accession number: Q3K7X5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families