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Q3K693

- PROA_PSEPF

UniProt

Q3K693 - PROA_PSEPF

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-5053-MONOMER.
    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Short name:
    GSA dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotation
    Ordered Locus Names:Pfl01_4974
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Gamma-glutamyl phosphate reductasePRO_0000230015Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205922.Pfl01_4974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K693.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0014.
    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiKESVNTF.
    OrthoDBiEOG6FFSCX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3K693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTESVLDYMT RLGRAAREAS RVIGRASTAQ KNRALLAAAN ALDAARAELA    50
    AANEQDLATG RANGLEPALL ERLELTPARI DGMIVGLRQV AALPDPVGAI 100
    RDMSFRPSGI QVGKMRVPLG VIGIIYESRP NVTIDAASLC LKSGNATILR 150
    GGSEAIHSNR AIAACIQRGL AAAELPAAVV QVVETTDRAA VGALITMPEY 200
    VDVIVPRGGR GLIERISRDA RVPVIKHLDG ICHVYVSEHA DLPKAQRIAF 250
    NAKTYRYGIC GAMETLLVDQ RVAKDFLPSM AKQFREKGVE LRGCERTRAI 300
    IEAVAATEED WSTEYLAPIL SIRVVDGLDQ AIEHINHFGS HHTDSIVSEN 350
    LADTRQFVAQ VDSASVMINT PTCFADGFEY GLGAEIGIST DKLHARGPVG 400
    LEGLTCEKYI VVGDGQLRGQ ATV 423
    Length:423
    Mass (Da):45,307
    Last modified:November 8, 2005 - v1
    Checksum:i0ECCEDBC508E5A60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76711.1.
    RefSeqiYP_350702.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA76711; ABA76711; Pfl01_4974.
    GeneIDi3715893.
    KEGGipfo:Pfl01_4974.
    PATRICi19892146. VBIPseFlu44242_4988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76711.1 .
    RefSeqi YP_350702.1. NC_007492.2.

    3D structure databases

    ProteinModelPortali Q3K693.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_4974.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA76711 ; ABA76711 ; Pfl01_4974 .
    GeneIDi 3715893.
    KEGGi pfo:Pfl01_4974.
    PATRICi 19892146. VBIPseFlu44242_4988.

    Phylogenomic databases

    eggNOGi COG0014.
    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi KESVNTF.
    OrthoDBi EOG6FFSCX.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .
    BioCyci PFLU205922:GJBD-5053-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiPROA_PSEPF
    AccessioniPrimary (citable) accession number: Q3K693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3