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Q3K651

- Q3K651_PSEPF

UniProt

Q3K651 - Q3K651_PSEPF

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Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotationSAAS annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 2415-amino-6-(D-ribitylamino)uracilUniRule annotation
Active sitei90 – 901Proton donorUniRule annotation
Binding sitei115 – 11515-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei129 – 12911-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-5095-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
Short name:
DMRL synthaseUniRule annotation
Short name:
LSUniRule annotation
Short name:
Lumazine synthaseUniRule annotation
Gene namesi
Name:ribHUniRule annotationImported
Ordered Locus Names:Pfl01_5016Imported
OrganismiPseudomonas fluorescens (strain Pf0-1)Imported
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.UniRule annotation

Protein-protein interaction databases

STRINGi205922.Pfl01_5016.

Structurei

3D structure databases

ProteinModelPortaliQ3K651.
SMRiQ3K651. Positions 3-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6035-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
Regioni82 – 8435-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
Regioni87 – 8821-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DMRL synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229249.
KOiK00794.
OMAiISRFNDF.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K651-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLKTIEGTF IAPKGRYALV VGRFNSFVVE SLVSGAVDAL VRHGVSESDI
60 70 80 90 100
TIIRAPGAFE IPLVAQKVAQ KGEFAAIIAL GAVIRGGTPH FEYVAGECTK
110 120 130 140 150
GLAQVSMEFG VPVAFGVLTV DSIEQAIERS GTKAGNKGAE AALSALEMVS

LLAQLEAK
Length:158
Mass (Da):16,418
Last modified:November 8, 2005 - v1
Checksum:iEFE4AE7AE2501CB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA76753.1.
RefSeqiYP_350744.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA76753; ABA76753; Pfl01_5016.
GeneIDi3713750.
KEGGipfo:Pfl01_5016.
PATRICi19892230. VBIPseFlu44242_5030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA76753.1 .
RefSeqi YP_350744.1. NC_007492.2.

3D structure databases

ProteinModelPortali Q3K651.
SMRi Q3K651. Positions 3-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_5016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA76753 ; ABA76753 ; Pfl01_5016 .
GeneIDi 3713750.
KEGGi pfo:Pfl01_5016.
PATRICi 19892230. VBIPseFlu44242_5030.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229249.
KOi K00794.
OMAi ISRFNDF.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci PFLU205922:GJBD-5095-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1Imported.

Entry informationi

Entry nameiQ3K651_PSEPF
AccessioniPrimary (citable) accession number: Q3K651
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3