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Q3K651

- Q3K651_PSEPF

UniProt

Q3K651 - Q3K651_PSEPF

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Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene
ribH, Pfl01_5016
Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin By similarity.UniRule annotationSAAS annotations

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 2415-amino-6-(D-ribitylamino)uracil By similarityUniRule annotation
Active sitei90 – 901Proton donor By similarityUniRule annotation
Binding sitei115 – 11515-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation
Binding sitei129 – 12911-deoxy-L-glycero-tetrulose 4-phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-5095-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
Short name:
DMRL synthaseUniRule annotation
Short name:
LSUniRule annotation
Short name:
Lumazine synthaseUniRule annotation
Gene namesi
Name:ribHUniRule annotationImported
Ordered Locus Names:Pfl01_5016Imported
OrganismiPseudomonas fluorescens (strain Pf0-1)Imported
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi205922.Pfl01_5016.

Structurei

3D structure databases

ProteinModelPortaliQ3K651.
SMRiQ3K651. Positions 3-156.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6035-amino-6-(D-ribitylamino)uracil binding By similarityUniRule annotation
Regioni82 – 8435-amino-6-(D-ribitylamino)uracil binding By similarityUniRule annotation
Regioni87 – 8821-deoxy-L-glycero-tetrulose 4-phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229249.
KOiK00794.
OMAiISRFNDF.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K651-1 [UniParc]FASTAAdd to Basket

« Hide

MTLKTIEGTF IAPKGRYALV VGRFNSFVVE SLVSGAVDAL VRHGVSESDI    50
TIIRAPGAFE IPLVAQKVAQ KGEFAAIIAL GAVIRGGTPH FEYVAGECTK 100
GLAQVSMEFG VPVAFGVLTV DSIEQAIERS GTKAGNKGAE AALSALEMVS 150
LLAQLEAK 158
Length:158
Mass (Da):16,418
Last modified:November 8, 2005 - v1
Checksum:iEFE4AE7AE2501CB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA76753.1.
RefSeqiYP_350744.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA76753; ABA76753; Pfl01_5016.
GeneIDi3713750.
KEGGipfo:Pfl01_5016.
PATRICi19892230. VBIPseFlu44242_5030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA76753.1 .
RefSeqi YP_350744.1. NC_007492.2.

3D structure databases

ProteinModelPortali Q3K651.
SMRi Q3K651. Positions 3-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_5016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA76753 ; ABA76753 ; Pfl01_5016 .
GeneIDi 3713750.
KEGGi pfo:Pfl01_5016.
PATRICi 19892230. VBIPseFlu44242_5030.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229249.
KOi K00794.
OMAi ISRFNDF.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci PFLU205922:GJBD-5095-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1Imported.

Entry informationi

Entry nameiQ3K651_PSEPF
AccessioniPrimary (citable) accession number: Q3K651
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi