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Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.SAAS annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.SAAS annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseSAAS annotationImported
Biological processRiboflavin biosynthesisSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthaseSAAS annotation (EC:2.5.1.78SAAS annotation)
Gene namesi
Name:ribHImported
Ordered Locus Names:Pfl01_5016Imported
OrganismiPseudomonas fluorescens (strain Pf0-1)Imported
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002704 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PRIDEiQ3K651.

Interactioni

Protein-protein interaction databases

STRINGi205922.Pfl01_5016.

Structurei

3D structure databases

ProteinModelPortaliQ3K651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108UTT. Bacteria.
COG0054. LUCA.
HOGENOMiHOG000229249.
KOiK00794.
OMAiWNYALQA.
OrthoDBiPOG091H021R.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
InterProiView protein in InterPro
IPR002180. LS/RS.
PfamiView protein in Pfam
PF00885. DMRL_synthase. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKTIEGTF IAPKGRYALV VGRFNSFVVE SLVSGAVDAL VRHGVSESDI
60 70 80 90 100
TIIRAPGAFE IPLVAQKVAQ KGEFAAIIAL GAVIRGGTPH FEYVAGECTK
110 120 130 140 150
GLAQVSMEFG VPVAFGVLTV DSIEQAIERS GTKAGNKGAE AALSALEMVS

LLAQLEAK
Length:158
Mass (Da):16,418
Last modified:November 8, 2005 - v1
Checksum:iEFE4AE7AE2501CB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA76753.1.
RefSeqiWP_003228649.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA76753; ABA76753; Pfl01_5016.
GeneIDi29578679.
KEGGipfo:Pfl01_5016.
PATRICi19892230. VBIPseFlu44242_5030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA76753.1.
RefSeqiWP_003228649.1. NC_007492.2.

3D structure databases

ProteinModelPortaliQ3K651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205922.Pfl01_5016.

Proteomic databases

PRIDEiQ3K651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA76753; ABA76753; Pfl01_5016.
GeneIDi29578679.
KEGGipfo:Pfl01_5016.
PATRICi19892230. VBIPseFlu44242_5030.

Phylogenomic databases

eggNOGiENOG4108UTT. Bacteria.
COG0054. LUCA.
HOGENOMiHOG000229249.
KOiK00794.
OMAiWNYALQA.
OrthoDBiPOG091H021R.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00404.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
InterProiView protein in InterPro
IPR002180. LS/RS.
PfamiView protein in Pfam
PF00885. DMRL_synthase. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3K651_PSEPF
AccessioniPrimary (citable) accession number: Q3K651
Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 10, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.