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Q3K651

- Q3K651_PSEPF

UniProt

Q3K651 - Q3K651_PSEPF

Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotationSAAS annotation

    Catalytic activityi

    1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 2415-amino-6-(D-ribitylamino)uracilUniRule annotation
    Active sitei90 – 901Proton donorUniRule annotation
    Binding sitei115 – 11515-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei129 – 12911-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

    GO - Molecular functioni

    1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Riboflavin biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-5095-MONOMER.
    UniPathwayiUPA00275; UER00404.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
    Short name:
    DMRL synthaseUniRule annotation
    Short name:
    LSUniRule annotation
    Short name:
    Lumazine synthaseUniRule annotation
    Gene namesi
    Name:ribHUniRule annotationImported
    Ordered Locus Names:Pfl01_5016Imported
    OrganismiPseudomonas fluorescens (strain Pf0-1)Imported
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. riboflavin synthase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.UniRule annotation

    Protein-protein interaction databases

    STRINGi205922.Pfl01_5016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K651.
    SMRiQ3K651. Positions 3-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 6035-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni82 – 8435-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni87 – 8821-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DMRL synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0054.
    HOGENOMiHOG000229249.
    KOiK00794.
    OMAiISRFNDF.
    OrthoDBiEOG6RC3WC.

    Family and domain databases

    Gene3Di3.40.50.960. 1 hit.
    HAMAPiMF_00178. Lumazine_synth.
    InterProiIPR002180. DMRL_synthase.
    [Graphical view]
    PANTHERiPTHR21058. PTHR21058. 1 hit.
    PfamiPF00885. DMRL_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52121. SSF52121. 1 hit.
    TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3K651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLKTIEGTF IAPKGRYALV VGRFNSFVVE SLVSGAVDAL VRHGVSESDI    50
    TIIRAPGAFE IPLVAQKVAQ KGEFAAIIAL GAVIRGGTPH FEYVAGECTK 100
    GLAQVSMEFG VPVAFGVLTV DSIEQAIERS GTKAGNKGAE AALSALEMVS 150
    LLAQLEAK 158
    Length:158
    Mass (Da):16,418
    Last modified:November 8, 2005 - v1
    Checksum:iEFE4AE7AE2501CB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76753.1.
    RefSeqiYP_350744.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA76753; ABA76753; Pfl01_5016.
    GeneIDi3713750.
    KEGGipfo:Pfl01_5016.
    PATRICi19892230. VBIPseFlu44242_5030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76753.1 .
    RefSeqi YP_350744.1. NC_007492.2.

    3D structure databases

    ProteinModelPortali Q3K651.
    SMRi Q3K651. Positions 3-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_5016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA76753 ; ABA76753 ; Pfl01_5016 .
    GeneIDi 3713750.
    KEGGi pfo:Pfl01_5016.
    PATRICi 19892230. VBIPseFlu44242_5030.

    Phylogenomic databases

    eggNOGi COG0054.
    HOGENOMi HOG000229249.
    KOi K00794.
    OMAi ISRFNDF.
    OrthoDBi EOG6RC3WC.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00404 .
    BioCyci PFLU205922:GJBD-5095-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.960. 1 hit.
    HAMAPi MF_00178. Lumazine_synth.
    InterProi IPR002180. DMRL_synthase.
    [Graphical view ]
    PANTHERi PTHR21058. PTHR21058. 1 hit.
    Pfami PF00885. DMRL_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52121. SSF52121. 1 hit.
    TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1Imported.

    Entry informationi

    Entry nameiQ3K651_PSEPF
    AccessioniPrimary (citable) accession number: Q3K651
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3