Reviewed, UniProtKB/Swiss-Prot Q3K5T0 (APAH_PSEPF)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	Pfl01_5137

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012081

Sequences

	Sequence		Length	Mass (Da)
	Q3K5T0-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: BE4D21F49B5D116A	FASTA	293	32,882
	10 20 30 40 50 60 MATYAVGDLQ GCLEPLKCLL QQVAFDPALD RLWLVGDLVN RGPQSLETLR FLYGMRESLV 70 80 90 100 110 120 CVLGNHDLHL LAAAKNIERL KKSDTLREIL EAPDCAELME WLRQQKLMHY DEQREVAMVH 130 140 150 160 170 180 AGIPPQWSLR KALKYAEEVE TALRDDNLLP PFLDGMYGNE PAKWDSDLKG VTRLRVITNY 190 200 210 220 230 240 FTRMRFCTAE GKLDLKSKEG LDTAPPGYKP WFQHKERKTR GLRIIFGHWA ALEGNVHEPG 250 260 270 280 290 ICALDTGCVW GGSLTLMNVD SGERLSCKCD EHGAALPTVA PLITESSPVS APR

References

[1]

"Complete sequence of Pseudomonas fluorescens PfO-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyripides N., Anderson I., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000094 Genomic DNA. Translation: ABA76874.1.
RefSeq	YP_350865.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3717268.
GenomeReviews	Gene locus Pfl01_5137 in contig CP000094_GR.
KEGG	pfo:Pfl01_5137.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3K5T0.
OMA	Q3K5T0. LVFGHWA.
Enzyme and pathway databases
BioCyc	PFLU205922:PFL_5137-MON.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_PSEPF

Accession

Primary (citable) accession number: Q3K5T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)