ID   BETB_PSEPF              Reviewed;         490 AA.
AC   Q3K5H4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=Pfl01_5243;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyripides N., Anderson I., Richardson P.;
RT   "Complete sequence of Pseudomonas fluorescens PfO-1.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000094; ABA76980.1; -; Genomic_DNA.
DR   RefSeq; YP_350971.1; -.
DR   GeneID; 3716194; -.
DR   GenomeReviews; CP000094_GR; Pfl01_5243.
DR   KEGG; pfo:Pfl01_5243; -.
DR   HOGENOM; Q3K5H4; -.
DR   OMA; Q3K5H4; AHRTIHR.
DR   BioCyc; PFLU205922:PFL_5243-MON; -.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR011264; Betaine_Ald_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    490       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_1000047050.
FT   NP_BIND     229    234       NAD (By similarity).
FT   ACT_SITE    252    252       By similarity.
FT   ACT_SITE    286    286       By similarity.
SQ   SEQUENCE   490 AA;  53174 MW;  C4D0AB6F274B3D75 CRC64;
     MARFELQKLY IDGAYSDAGS DATFEAINPA NGEVLAHVQR ATKEDVERAV VSAEKGQKIW
     AAMTAMERSR ILRRAVDILR ERNDELAALE TLDTGKAFSE TKYVDIVTGA DVLEYYAGLV
     PAIEGEQIPL RDTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV
     TSLTTLKLAE IYTEAGVPNG VFNVLTGSGR EVGTWLTEHP RIEKISFTGG TDTGKKVMAS
     ASASSLKDVT MELGGKSPLI ICDDADLDRA ADTAMMANFY SSGQVCTNGT RVFVPSHLKA
     AFEAKIVERV ARIRVGNPED ENTNFGPLVS FPHMESVLGY IAKGKEEGAR VLCGGERLTD
     GEFAKGAFVA PTVFTDCTDD MTIVREEIFG PVMAILSYET EEEVIRRAND TDFGLAAGIV
     TRDLNRAHRV IHQLEAGICW INAWGESDAK MPVGGYKQSG VGRENGISSL NNFTRIKSVQ
     VELGDYVSVF
//