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Q3K5H4 (BETB_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Pfl01_5243
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_1000047050

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K5H4 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: C4D0AB6F274B3D75

FASTA49053,174
        10         20         30         40         50         60 
MARFELQKLY IDGAYSDAGS DATFEAINPA NGEVLAHVQR ATKEDVERAV VSAEKGQKIW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVDILR ERNDELAALE TLDTGKAFSE TKYVDIVTGA DVLEYYAGLV 

       130        140        150        160        170        180 
PAIEGEQIPL RDTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TSLTTLKLAE IYTEAGVPNG VFNVLTGSGR EVGTWLTEHP RIEKISFTGG TDTGKKVMAS 

       250        260        270        280        290        300 
ASASSLKDVT MELGGKSPLI ICDDADLDRA ADTAMMANFY SSGQVCTNGT RVFVPSHLKA 

       310        320        330        340        350        360 
AFEAKIVERV ARIRVGNPED ENTNFGPLVS FPHMESVLGY IAKGKEEGAR VLCGGERLTD 

       370        380        390        400        410        420 
GEFAKGAFVA PTVFTDCTDD MTIVREEIFG PVMAILSYET EEEVIRRAND TDFGLAAGIV 

       430        440        450        460        470        480 
TRDLNRAHRV IHQLEAGICW INAWGESDAK MPVGGYKQSG VGRENGISSL NNFTRIKSVQ 

       490 
VELGDYVSVF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000094 Genomic DNA. Translation: ABA76980.1.
RefSeqYP_350971.1. NC_007492.2.

3D structure databases

HSSPHSSP built from PDB template 1BPW based on UniProtKB P56533.
ProteinModelPortalQ3K5H4.
SMRQ3K5H4. Positions 8-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3K5H4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3716194.
GenomeReviewsGene locus Pfl01_5243 in contig CP000094_GR.
KEGGpfo:Pfl01_5243.
PATRIC19892706. VBIPseFlu44242_5258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAAHRTIHR.
PhylomeDBQ3K5H4.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycPFLU205922:PFL_5243-MONOMER.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00130.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_PSEPF
AccessionPrimary (citable) accession number: Q3K5H4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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