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Q3K5H4

- BETB_PSEPF

UniProt

Q3K5H4 - BETB_PSEPF

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei162 – 1621Charge relay systemUniRule annotation
    Metal bindingi180 – 1801Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei209 – 2091NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi246 – 2461Potassium 2; via carbonyl oxygenUniRule annotation
    Sitei248 – 2481Seems to be a necessary countercharge to the potassium cationsUniRule annotation
    Active sitei252 – 2521Proton acceptorUniRule annotation
    Binding sitei286 – 2861NAD/NADPUniRule annotation
    Binding sitei387 – 3871NAD/NADPUniRule annotation
    Metal bindingi457 – 4571Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi460 – 4601Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei464 – 4641Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi150 – 1534NAD/NADPUniRule annotation
    Nucleotide bindingi176 – 1794NAD/NADPUniRule annotation
    Nucleotide bindingi229 – 2346NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-5332-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:Pfl01_5243
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000047050Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei286 – 2861Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi205922.Pfl01_5243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K5H4.
    SMRiQ3K5H4. Positions 8-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiSKMTAME.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3K5H4-1 [UniParc]FASTAAdd to Basket

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    MARFELQKLY IDGAYSDAGS DATFEAINPA NGEVLAHVQR ATKEDVERAV    50
    VSAEKGQKIW AAMTAMERSR ILRRAVDILR ERNDELAALE TLDTGKAFSE 100
    TKYVDIVTGA DVLEYYAGLV PAIEGEQIPL RDTSFVYTRR EPLGVVAGIG 150
    AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTTLKLAE IYTEAGVPNG 200
    VFNVLTGSGR EVGTWLTEHP RIEKISFTGG TDTGKKVMAS ASASSLKDVT 250
    MELGGKSPLI ICDDADLDRA ADTAMMANFY SSGQVCTNGT RVFVPSHLKA 300
    AFEAKIVERV ARIRVGNPED ENTNFGPLVS FPHMESVLGY IAKGKEEGAR 350
    VLCGGERLTD GEFAKGAFVA PTVFTDCTDD MTIVREEIFG PVMAILSYET 400
    EEEVIRRAND TDFGLAAGIV TRDLNRAHRV IHQLEAGICW INAWGESDAK 450
    MPVGGYKQSG VGRENGISSL NNFTRIKSVQ VELGDYVSVF 490
    Length:490
    Mass (Da):53,174
    Last modified:November 8, 2005 - v1
    Checksum:iC4D0AB6F274B3D75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76980.1.
    RefSeqiWP_011336306.1. NC_007492.2.
    YP_350971.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA76980; ABA76980; Pfl01_5243.
    GeneIDi3716194.
    KEGGipfo:Pfl01_5243.
    PATRICi19892706. VBIPseFlu44242_5258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76980.1 .
    RefSeqi WP_011336306.1. NC_007492.2.
    YP_350971.1. NC_007492.2.

    3D structure databases

    ProteinModelPortali Q3K5H4.
    SMRi Q3K5H4. Positions 8-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_5243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA76980 ; ABA76980 ; Pfl01_5243 .
    GeneIDi 3716194.
    KEGGi pfo:Pfl01_5243.
    PATRICi 19892706. VBIPseFlu44242_5258.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi SKMTAME.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci PFLU205922:GJBD-5332-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiBETB_PSEPF
    AccessioniPrimary (citable) accession number: Q3K5H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3