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Q3K5H3 (BETA_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:Pfl01_5244
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000258929

Regions

Nucleotide binding6 – 3530FAD By similarity

Sites

Active site4751 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K5H3 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 55298A5390F9725F

FASTA56762,522
        10         20         30         40         50         60 
MSQEFDYIIV GAGSAGNTLA TRLTEDEGVT VLLLEAGGPD YRFDFRTQMP AALAFPLQGR 

        70         80         90        100        110        120 
RYNWAYETDP EPHMDGRRME CGRGKGLGGS SLINGMCYIR GNAMDYDGWA KLPGLEDWSY 

       130        140        150        160        170        180 
LDCLPYFRKA ETRDIGPNDY HGGDGPVSVT TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG 

       190        200        210        220        230        240 
YQQEGFGPMD RTVTPNGRRA STARGYLDVA KKRSTLTIVT HALTDKVLFE GKRAVGVRYL 

       250        260        270        280        290        300 
VGAAEERVEA RARKEVIVCS GAIASPQLLQ RSGVGPAKLL ESLDIPVVHD LPGVGENLQD 

       310        320        330        340        350        360 
HLELYLQYAC TQPVSLYPSL LWYNQPAIGA EWLFNGTGIG ASNQFEAGGF IRTRPEFEWP 

       370        380        390        400        410        420 
NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPSRGRVQ VKSKDPRQHP SILFNYMATE 

       430        440        450        460        470        480 
QDWQEFRDGI RLTREIMQQP ALDAFRGREI SPGIEVQTDE QLDKFIREHA ETAFHPSCSC 

       490        500        510        520        530        540 
KMGTDDMAVV DGEGRVHGMQ GLRVVDASIM PIITTGNLNA PTIMMAEKIA DKIRGRQPLP 

       550        560 
RSKAPYYVAG DAPVKGKAMR DVSAVAQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000094 Genomic DNA. Translation: ABA76981.1.
RefSeqYP_350972.1. NC_007492.2.

3D structure databases

ProteinModelPortalQ3K5H3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205922.Pfl01_5244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA76981; ABA76981; Pfl01_5244.
GeneID3716195.
KEGGpfo:Pfl01_5244.
PATRIC19892708. VBIPseFlu44242_5259.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycPFLU205922:GJBD-5333-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_PSEPF
AccessionPrimary (citable) accession number: Q3K5H3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways