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Q3K5H3

- BETA_PSEPF

UniProt

Q3K5H3 - BETA_PSEPF

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei475 – 4751UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3530FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-5333-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:Pfl01_5244
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Oxygen-dependent choline dehydrogenasePRO_0000258929Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205922.Pfl01_5244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K5H3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3K5H3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQEFDYIIV GAGSAGNTLA TRLTEDEGVT VLLLEAGGPD YRFDFRTQMP    50
    AALAFPLQGR RYNWAYETDP EPHMDGRRME CGRGKGLGGS SLINGMCYIR 100
    GNAMDYDGWA KLPGLEDWSY LDCLPYFRKA ETRDIGPNDY HGGDGPVSVT 150
    TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG YQQEGFGPMD RTVTPNGRRA 200
    STARGYLDVA KKRSTLTIVT HALTDKVLFE GKRAVGVRYL VGAAEERVEA 250
    RARKEVIVCS GAIASPQLLQ RSGVGPAKLL ESLDIPVVHD LPGVGENLQD 300
    HLELYLQYAC TQPVSLYPSL LWYNQPAIGA EWLFNGTGIG ASNQFEAGGF 350
    IRTRPEFEWP NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPSRGRVQ 400
    VKSKDPRQHP SILFNYMATE QDWQEFRDGI RLTREIMQQP ALDAFRGREI 450
    SPGIEVQTDE QLDKFIREHA ETAFHPSCSC KMGTDDMAVV DGEGRVHGMQ 500
    GLRVVDASIM PIITTGNLNA PTIMMAEKIA DKIRGRQPLP RSKAPYYVAG 550
    DAPVKGKAMR DVSAVAQ 567
    Length:567
    Mass (Da):62,522
    Last modified:November 8, 2005 - v1
    Checksum:i55298A5390F9725F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76981.1.
    RefSeqiWP_011336307.1. NC_007492.2.
    YP_350972.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA76981; ABA76981; Pfl01_5244.
    GeneIDi3716195.
    KEGGipfo:Pfl01_5244.
    PATRICi19892708. VBIPseFlu44242_5259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA76981.1 .
    RefSeqi WP_011336307.1. NC_007492.2.
    YP_350972.1. NC_007492.2.

    3D structure databases

    ProteinModelPortali Q3K5H3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_5244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA76981 ; ABA76981 ; Pfl01_5244 .
    GeneIDi 3716195.
    KEGGi pfo:Pfl01_5244.
    PATRICi 19892708. VBIPseFlu44242_5259.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci PFLU205922:GJBD-5333-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiBETA_PSEPF
    AccessioniPrimary (citable) accession number: Q3K5H3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3