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Q3K4Z1 (GCSP2_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene names
Name:gcvP2
Ordered Locus Names:Pfl01_5426
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) 2 HAMAP-Rule MF_00711
PRO_0000227119

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K4Z1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 9F8868B26BEF8AC6

FASTA957104,242
        10         20         30         40         50         60 
MSQLPSLSQL RDPHAFLRRH LGPDAAEQQA MLDSLGLGSR VELIEQTVPP GIRLNRELDL 

        70         80         90        100        110        120 
PPALDEQAAL ARLRGYAEQN QVWTSLIGMG YHGTLTPTVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEALL NFQQLTIDLT GLELANASLL DEATAAAEAM ALAKRVAKSK SNLFFVDENC 

       190        200        210        220        230        240 
HPQTISVVQT RAEGFGFELI VDAVDNLKQH QVFGALLQYP DTHGEIRDLR PLIDHLHAQQ 

       250        260        270        280        290        300 
ALACVAADLL SLLLLTPPGE LGADVVFGSS QRFGVPMGYG GPHAAVFASR EEYKRAIPGR 

       310        320        330        340        350        360 
IIGVSKDARG NVALRMALQT REQHIRREKA NSNICTAQVL LANIASFYAV YHGPEGLKRI 

       370        380        390        400        410        420 
AQRVHRLTCI LAAGLERHGI QRLNQHFFDT LTLDVGGAQT AIIESAQAAQ INLRILGRGQ 

       430        440        450        460        470        480 
LGLSLDEACD ENTVARLFDV LLGADHGLSI DDLDAETLAS GIPEMLQRST SYLRHPVFNA 

       490        500        510        520        530        540 
HHSETEMLRY LKQLENKDLA LNQSMIPLGS CTMKLNATSE MIPITWPQFA NLHPFVPREQ 

       550        560        570        580        590        600 
AVGYTLMIEE LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRKYHESRQ QGGRDICLIP 

       610        620        630        640        650        660 
SSAHGTNPAS AQMAGMRVVI VECDDAGNVD LEDLKAKASE AGAKLSCLMA TYPSTHGVYE 

       670        680        690        700        710        720 
EGISEICEVI HKHGGQVYMD GANLNAQVGL ARPADIGADV SHMNLHKTFC IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGVRAHLA PFVANHPVVP IDGPQPQNGA VSAAPWGSAS ILPISWMYIA MMGPQLADAS 

       790        800        810        820        830        840 
EVAILAANYL AQHLSGAFPV LYTGRNERVA HECILDLRPL KAATGISEED VAKRLMDYGF 

       850        860        870        880        890        900 
HAPTMSFPVP GTLMVEPTES ESKAELDRFI GAMLSIRAEI TEVQNGNWPA EDNPLKRAPH 

       910        920        930        940        950 
TMADITGVWE RPYSIEQGIT PDAHTKAHKY WPAVNRVDNV YGDRNLFCAC VPVDDYR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000094 Genomic DNA. Translation: ABA77163.1.
RefSeqYP_351154.1. NC_007492.2.

3D structure databases

ProteinModelPortalQ3K4Z1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205922.Pfl01_5426.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA77163; ABA77163; Pfl01_5426.
GeneID3714330.
KEGGpfo:Pfl01_5426.
PATRIC19893082. VBIPseFlu44242_5446.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPFLU205922:GJBD-5515-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP2_PSEPF
AccessionPrimary (citable) accession number: Q3K4Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families