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Q3K4Z1

- GCSP2_PSEPF

UniProt

Q3K4Z1 - GCSP2_PSEPF

Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPFLU205922:GJBD-5515-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein 2UniRule annotation
    Glycine decarboxylase 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) 2UniRule annotation
    Gene namesi
    Name:gcvP2UniRule annotation
    Ordered Locus Names:Pfl01_5426
    OrganismiPseudomonas fluorescens (strain Pf0-1)
    Taxonomic identifieri205922 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002704: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2PRO_0000227119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi205922.Pfl01_5426.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3K4Z1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3K4Z1-1 [UniParc]FASTAAdd to Basket

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    MSQLPSLSQL RDPHAFLRRH LGPDAAEQQA MLDSLGLGSR VELIEQTVPP    50
    GIRLNRELDL PPALDEQAAL ARLRGYAEQN QVWTSLIGMG YHGTLTPTVI 100
    LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQLTIDLT GLELANASLL 150
    DEATAAAEAM ALAKRVAKSK SNLFFVDENC HPQTISVVQT RAEGFGFELI 200
    VDAVDNLKQH QVFGALLQYP DTHGEIRDLR PLIDHLHAQQ ALACVAADLL 250
    SLLLLTPPGE LGADVVFGSS QRFGVPMGYG GPHAAVFASR EEYKRAIPGR 300
    IIGVSKDARG NVALRMALQT REQHIRREKA NSNICTAQVL LANIASFYAV 350
    YHGPEGLKRI AQRVHRLTCI LAAGLERHGI QRLNQHFFDT LTLDVGGAQT 400
    AIIESAQAAQ INLRILGRGQ LGLSLDEACD ENTVARLFDV LLGADHGLSI 450
    DDLDAETLAS GIPEMLQRST SYLRHPVFNA HHSETEMLRY LKQLENKDLA 500
    LNQSMIPLGS CTMKLNATSE MIPITWPQFA NLHPFVPREQ AVGYTLMIEE 550
    LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRKYHESRQ QGGRDICLIP 600
    SSAHGTNPAS AQMAGMRVVI VECDDAGNVD LEDLKAKASE AGAKLSCLMA 650
    TYPSTHGVYE EGISEICEVI HKHGGQVYMD GANLNAQVGL ARPADIGADV 700
    SHMNLHKTFC IPHGGGGPGM GPIGVRAHLA PFVANHPVVP IDGPQPQNGA 750
    VSAAPWGSAS ILPISWMYIA MMGPQLADAS EVAILAANYL AQHLSGAFPV 800
    LYTGRNERVA HECILDLRPL KAATGISEED VAKRLMDYGF HAPTMSFPVP 850
    GTLMVEPTES ESKAELDRFI GAMLSIRAEI TEVQNGNWPA EDNPLKRAPH 900
    TMADITGVWE RPYSIEQGIT PDAHTKAHKY WPAVNRVDNV YGDRNLFCAC 950
    VPVDDYR 957
    Length:957
    Mass (Da):104,242
    Last modified:November 8, 2005 - v1
    Checksum:i9F8868B26BEF8AC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA77163.1.
    RefSeqiWP_011336463.1. NC_007492.2.
    YP_351154.1. NC_007492.2.

    Genome annotation databases

    EnsemblBacteriaiABA77163; ABA77163; Pfl01_5426.
    GeneIDi3714330.
    KEGGipfo:Pfl01_5426.
    PATRICi19893082. VBIPseFlu44242_5446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000094 Genomic DNA. Translation: ABA77163.1 .
    RefSeqi WP_011336463.1. NC_007492.2.
    YP_351154.1. NC_007492.2.

    3D structure databases

    ProteinModelPortali Q3K4Z1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205922.Pfl01_5426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA77163 ; ABA77163 ; Pfl01_5426 .
    GeneIDi 3714330.
    KEGGi pfo:Pfl01_5426.
    PATRICi 19893082. VBIPseFlu44242_5446.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PFLU205922:GJBD-5515-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf0-1.

    Entry informationi

    Entry nameiGCSP2_PSEPF
    AccessioniPrimary (citable) accession number: Q3K4Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3