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Q3K4Z1

- GCSP2_PSEPF

UniProt

Q3K4Z1 - GCSP2_PSEPF

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Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-5515-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein 2UniRule annotation
Glycine decarboxylase 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) 2UniRule annotation
Gene namesi
Name:gcvP2UniRule annotation
Ordered Locus Names:Pfl01_5426
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2PRO_0000227119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi205922.Pfl01_5426.

Structurei

3D structure databases

ProteinModelPortaliQ3K4Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K4Z1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSQLPSLSQL RDPHAFLRRH LGPDAAEQQA MLDSLGLGSR VELIEQTVPP
60 70 80 90 100
GIRLNRELDL PPALDEQAAL ARLRGYAEQN QVWTSLIGMG YHGTLTPTVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQLTIDLT GLELANASLL
160 170 180 190 200
DEATAAAEAM ALAKRVAKSK SNLFFVDENC HPQTISVVQT RAEGFGFELI
210 220 230 240 250
VDAVDNLKQH QVFGALLQYP DTHGEIRDLR PLIDHLHAQQ ALACVAADLL
260 270 280 290 300
SLLLLTPPGE LGADVVFGSS QRFGVPMGYG GPHAAVFASR EEYKRAIPGR
310 320 330 340 350
IIGVSKDARG NVALRMALQT REQHIRREKA NSNICTAQVL LANIASFYAV
360 370 380 390 400
YHGPEGLKRI AQRVHRLTCI LAAGLERHGI QRLNQHFFDT LTLDVGGAQT
410 420 430 440 450
AIIESAQAAQ INLRILGRGQ LGLSLDEACD ENTVARLFDV LLGADHGLSI
460 470 480 490 500
DDLDAETLAS GIPEMLQRST SYLRHPVFNA HHSETEMLRY LKQLENKDLA
510 520 530 540 550
LNQSMIPLGS CTMKLNATSE MIPITWPQFA NLHPFVPREQ AVGYTLMIEE
560 570 580 590 600
LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRKYHESRQ QGGRDICLIP
610 620 630 640 650
SSAHGTNPAS AQMAGMRVVI VECDDAGNVD LEDLKAKASE AGAKLSCLMA
660 670 680 690 700
TYPSTHGVYE EGISEICEVI HKHGGQVYMD GANLNAQVGL ARPADIGADV
710 720 730 740 750
SHMNLHKTFC IPHGGGGPGM GPIGVRAHLA PFVANHPVVP IDGPQPQNGA
760 770 780 790 800
VSAAPWGSAS ILPISWMYIA MMGPQLADAS EVAILAANYL AQHLSGAFPV
810 820 830 840 850
LYTGRNERVA HECILDLRPL KAATGISEED VAKRLMDYGF HAPTMSFPVP
860 870 880 890 900
GTLMVEPTES ESKAELDRFI GAMLSIRAEI TEVQNGNWPA EDNPLKRAPH
910 920 930 940 950
TMADITGVWE RPYSIEQGIT PDAHTKAHKY WPAVNRVDNV YGDRNLFCAC

VPVDDYR
Length:957
Mass (Da):104,242
Last modified:November 8, 2005 - v1
Checksum:i9F8868B26BEF8AC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA77163.1.
RefSeqiYP_351154.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA77163; ABA77163; Pfl01_5426.
GeneIDi3714330.
KEGGipfo:Pfl01_5426.
PATRICi19893082. VBIPseFlu44242_5446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA77163.1 .
RefSeqi YP_351154.1. NC_007492.2.

3D structure databases

ProteinModelPortali Q3K4Z1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_5426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA77163 ; ABA77163 ; Pfl01_5426 .
GeneIDi 3714330.
KEGGi pfo:Pfl01_5426.
PATRICi 19893082. VBIPseFlu44242_5446.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PFLU205922:GJBD-5515-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiGCSP2_PSEPF
AccessioniPrimary (citable) accession number: Q3K4Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3