Reviewed, UniProtKB/Swiss-Prot Q3K4S8 (ARLY2_PSEPF)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase 2
      Short name=ASAL 2
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase 2

Gene names

Name:	argH2
Ordered Locus Names:	Pfl01_5489

Organism

Pseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]

Taxonomic identifier

205922 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Argininosuccinate lyase 2 HAMAP MF_00006		PRO_0000240753

Sequences

	Sequence		Length	Mass (Da)
	Q3K4S8-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: AC00BE9F81D97D64	FASTA	464	51,682
	10 20 30 40 50 60 MSTDKTNQSW GGRFSEPVDA FVARFTASVT FDQRLYRHDI MGSIAHATML AKVGVLTDAE 70 80 90 100 110 120 RDSIIDGLKT IQGEIEAGQF DWRVDLEDVH MNIEARLTDR IGVTGKKLHT GRSRNDQVAT 130 140 150 160 170 180 DIRLWLRDEI DLILSEITRL QKGLLEQAER EAASIMPGFT HLQTAQPVTF GHHMLAWFEM 190 200 210 220 230 240 LSRDYERLVD CRKRTNRMPL GSAALAGTTY PIDREYTAQL LGFDAVGGNS LDNVSDRDFA 250 260 270 280 290 300 IEFCSAASIA MMHLSRFSEE LVLWTSAQFQ FIDLPDRFCT GSSIMPQKKN PDVPELVRGK 310 320 330 340 350 360 TGRVFGALMG LLTLMKGQPL AYNKDNQEDK EPLFDAADTL RDSLRAFADM IPAIKPKHAI 370 380 390 400 410 420 MREAALRGFS TATDLADYLV RRGLPFRDCH EIVGHAVKYG VDTGKDLAEM SLEELRQFSD 430 440 450 460 QIEQDVFAVL TLEGSVNARD HIGGTAPAQV KAAVVRGQAL IASR

References

[1]

"Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens." Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R., Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M., Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J., Harris S., Challis G.L., Yaxley A.M., Harris D. , Seeger K., Murphy L., Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K., Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M., Parkhill J., Levy S.B., Rainey P.B., Thomson N.R. Genome Biol. 10:RESEARCH51.1-RESEARCH51.16(2009) [PubMed: 19432983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000094 Genomic DNA. Translation: ABA77226.1.
RefSeq	YP_351217.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3K4S8.
Genome annotation databases
GeneID	3713813.
GenomeReviews	Gene locus Pfl01_5489 in contig CP000094_GR.
KEGG	pfo:Pfl01_5489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3K4S8.
OMA	ATDTRLY.
Enzyme and pathway databases
BioCyc	PFLU205922:PFL_5489-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY2_PSEPF

Accession

Primary (citable) accession number: Q3K4S8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 8, 2005
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)