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Protein

Probable chorismate pyruvate-lyase 2

Gene

ubiC2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76SubstrateUniRule annotation1
Binding sitei114Substrate; via amide nitrogenUniRule annotation1
Binding sitei166SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chorismate pyruvate-lyase 2UniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CL 2UniRule annotation
Short name:
CPL 2UniRule annotation
Gene namesi
Name:ubiC2UniRule annotation
Ordered Locus Names:Pfl01_5603
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002704 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002405581 – 183Probable chorismate pyruvate-lyase 2Add BLAST183

Interactioni

Protein-protein interaction databases

STRINGi205922.Pfl01_5603.

Structurei

3D structure databases

ProteinModelPortaliQ3K4G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VEI. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OMAiEVCHYPE.
OrthoDBiPOG091H047C.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3K4G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHTNAPLWR PQSELTPLPD TSTLDWLFDE GSLTRRLTHL SDDGFSVTPL
60 70 80 90 100
FEGWQTLRDD ECAALDLAEG SEGWVREVYL RGHGQAWVFA RSVASRSALQ
110 120 130 140 150
GDGLHMDELG SRSLGELLFC DHAFQRRAIE VCHYPEHWLP EGSRAAGLWG
160 170 180
RRSRFDRGAL SVLVAEIFLP TLWEAVRARP ENC
Length:183
Mass (Da):20,716
Last modified:November 8, 2005 - v1
Checksum:i456526ADCE1FD064
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA77340.1.
RefSeqiWP_011336606.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA77340; ABA77340; Pfl01_5603.
KEGGipfo:Pfl01_5603.
PATRICi19893428. VBIPseFlu44242_5619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA. Translation: ABA77340.1.
RefSeqiWP_011336606.1. NC_007492.2.

3D structure databases

ProteinModelPortaliQ3K4G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205922.Pfl01_5603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA77340; ABA77340; Pfl01_5603.
KEGGipfo:Pfl01_5603.
PATRICi19893428. VBIPseFlu44242_5619.

Phylogenomic databases

eggNOGiENOG4105VEI. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OMAiEVCHYPE.
OrthoDBiPOG091H047C.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIC2_PSEPF
AccessioniPrimary (citable) accession number: Q3K4G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.