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Q3K4B0

- GCH4_PSEPF

UniProt

Q3K4B0 - GCH4_PSEPF

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPFLU205922:GJBD-5745-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Pfl01_5658
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002704: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2PRO_0000289510Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205922.Pfl01_5658.

Structurei

3D structure databases

ProteinModelPortaliQ3K4B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3K4B0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALTLPDVA AQAARQALPL EWVGMCGIAL PVFIEGQRLA AKADAGVSLD
60 70 80 90 100
DGDARGIHMS RLYLGLEAME QQNLSPALLR QVLQRFLDSH EDLSEAAYLN
110 120 130 140 150
IHIDLLLRRP ALVSPLAGWK NYPVTVSAQL KNKVFHVELK IDVAYSSTCP
160 170 180 190 200
CSAALARQLI QQQFVDDFAN KPLQHADVLA WLGSTQGIVA TPHSQRSTAQ
210 220 230 240 250
LHLHLDEFVD ELPLTSIIND AEAALGTAVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAARRLN LALRGSPGIS QFHVRVIHAE SLHAHDAVAE SHWRREQP
Length:298
Mass (Da):32,630
Last modified:November 8, 2005 - v1
Checksum:i6BB9A08D174BE18C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA77394.1.
RefSeqiWP_011336651.1. NC_007492.2.
YP_351385.1. NC_007492.2.

Genome annotation databases

EnsemblBacteriaiABA77394; ABA77394; Pfl01_5658.
GeneIDi3717452.
KEGGipfo:Pfl01_5658.
PATRICi19893544. VBIPseFlu44242_5677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000094 Genomic DNA. Translation: ABA77394.1 .
RefSeqi WP_011336651.1. NC_007492.2.
YP_351385.1. NC_007492.2.

3D structure databases

ProteinModelPortali Q3K4B0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205922.Pfl01_5658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA77394 ; ABA77394 ; Pfl01_5658 .
GeneIDi 3717452.
KEGGi pfo:Pfl01_5658.
PATRICi 19893544. VBIPseFlu44242_5677.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PFLU205922:GJBD-5745-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf0-1.

Entry informationi

Entry nameiGCH4_PSEPF
AccessioniPrimary (citable) accession number: Q3K4B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3