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Q3K4B0 (GCH4_PSEPF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Pfl01_5658
OrganismPseudomonas fluorescens (strain Pf0-1) [Complete proteome] [HAMAP]
Taxonomic identifier205922 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289510

Sites

Site1491May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3K4B0 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 6BB9A08D174BE18C

FASTA29832,630
        10         20         30         40         50         60 
MNALTLPDVA AQAARQALPL EWVGMCGIAL PVFIEGQRLA AKADAGVSLD DGDARGIHMS 

        70         80         90        100        110        120 
RLYLGLEAME QQNLSPALLR QVLQRFLDSH EDLSEAAYLN IHIDLLLRRP ALVSPLAGWK 

       130        140        150        160        170        180 
NYPVTVSAQL KNKVFHVELK IDVAYSSTCP CSAALARQLI QQQFVDDFAN KPLQHADVLA 

       190        200        210        220        230        240 
WLGSTQGIVA TPHSQRSTAQ LHLHLDEFVD ELPLTSIIND AEAALGTAVQ TAVKRADEQA 

       250        260        270        280        290 
FALANGQNLM FCEDAARRLN LALRGSPGIS QFHVRVIHAE SLHAHDAVAE SHWRREQP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000094 Genomic DNA. Translation: ABA77394.1.
RefSeqYP_351385.1. NC_007492.2.

3D structure databases

ProteinModelPortalQ3K4B0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205922.Pfl01_5658.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA77394; ABA77394; Pfl01_5658.
GeneID3717452.
KEGGpfo:Pfl01_5658.
PATRIC19893544. VBIPseFlu44242_5677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAAGRTTIQ.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycPFLU205922:GJBD-5745-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEPF
AccessionPrimary (citable) accession number: Q3K4B0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways